Antinuclear Antibody Profiling in Patients of a Tertiary Care Centre in Central India

Gupta, Prishni; Agrawal, Pratishtha; Verma, Neha; Shah, Seema; Patel, Suprava; Nanda, Rachita; Mohapatra, Eli

doi:10.1007/s12291-020-00925-2

Cited by 4 publications

(2 citation statements)

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“…11, Issue 3, March 2024 concordance with the study carried out by Imran K et al, [19] while a study from Central India has reported this ratio to be 4.5:1. [1] The prevalence of ANAs in the healthy population increases with age, and ANAs are twice as likely to be detected in healthy women compared with men. Though, the association between strong ANA positivity and female gender has not yet been fully elucidated, a few possible causes include the presence of increased adipose tissue content in women which is capable of producing pro-inflammatory cytokines and estrogen which may lead to autoimmune disorders.…”

Section: Frequency Of Antinuclear Antibody Patternsmentioning

confidence: 99%

“…Autoimmune disorders in India have seen a rise in the recent times with an estimated prevalence of 4.5%. [1] These disorders are A-11 www.pacificejournals.com/apalm eISSN: 2349-6983; pISSN: 2394-6466 caused by immune responses mediated by auto antibodies, against host antigens or self-antigens. An autoimmune response is a common manifestation of connective tissue disease (CTD).…”

Section: Introductionmentioning

confidence: 99%

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Frequency of Immunofluorescence Antinuclear Antibody Patterns: In A Local Population from North India

Deepak,

Agrawal,

Kapoor

et al. 2024

Ann of Pathol and Lab Med

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Background Autoimmune disorders in India have seen rise in recent times. The first-line test in diagnostic workup of autoimmune disorders is ANA indirect Immunofluorescence (IIF). A positive Antinuclear antibodies (ANA) result in conjunction with clinical findings aids in predicting the diagnosis. ANA test is not widely available in India, probably due to the cost and requirement of technical expertise. In view of rising incidence of autoimmune disorders in India and due to scarcity of data, this study aimed at determining prevalence of ANA positivity, study ANA patterns and their frequency and estimate disease burden in patients among local population of Northern India. Methods The study was performed on 2000 suspected autoimmune disorder patients during a period of 01 year (January 2023 till January 2024). Assessment of ANA patterns and titres were carried out by ANA-IIF technique. Result Of the 2000 participants, 30.8% were found to be ANA-positive. Nuclear speckled pattern was observed to be the most common, among others. Among mixed ANA patterns, mix of speckled and homogenous patterns were common. Females showed predominance over males in all age groups in ratio of 3:1. Conclusion: The study is a preliminary, retrospective study providing overview of ANA positivity and autoimmunity status in Northern India, where despite the heavy disease burden, data is still scarce. Further studies in Indian population are essential to determine relationship of ANA with various etiologic and biochemical factors and association between ANA patterns and specific antibodies in serum for diagnosis of specific autoimmune diseases.

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Section: Frequency Of Antinuclear Antibody Patternsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%