Antiobesity Activity of <i>Bauhinia purpurea</i> Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

Abstract

Obesity is well recognized as a global public health concern and the quest continues to explore natural product-based novel therapeutics. Bauhinia purpurea finds its place in traditional medicine as an effective anti-ulcer, antiplatelet, wound healing and hypolipidemic agent. The present study investigated the effects of ethanolic extract of Bauhinia purpurea (EEB) on the changes in body weight, lean mass, fat free mass, fat percent, tissue and plasma lipid profiles, plasma glucose, insulin and insulin resistance as well as on the activity of amylase, lipase, leptin and adiponectin levels in high caloric diet (HCD) induced obese rats. After induction of obesity with HCD, rats were administered orally with EEB (100, 200 and 300 mg•kg −1 BW) or orlistat (5 mg•kg −1 BW) once daily for 42 days. HCD substantially increased the body weight, fat free mass, fat percent, glucose, insulin resistance, tissue and plasma lipid profiles (Except HDL), leptin and the activities of amylase and lipase. EEB at a dose of 300 mg•kg −1 BW exerted its therapeutic effects similar to orlistat in decreasing body weight, insulin resistance, levels of glucose, leptin, plasma and tissue lipids, lipase and amylase but increasing HDL and adiponectin in HCD fed obese rats, which could be due to bioactive factors present in EEB, as revealed by LC-MS analysis. These findings suggest that EEB administration suppresses high-caloric-diet-induced obesity and it can be developed as a potential candidate for the treatment of obesity and associated complications.

Effects of phenolic-rich extracts of Clinacanthus nutans on high fat and high cholesterol diet-induced insulin resistance

“…It has been observed that the disorders induced by high fat feeding resemble the human metabolic syndrome closely, with implications for the cardiovascular health [ 28 ]. We observed significant increase in liver weight in the HFHC group similar to the findings of Padmaja et al [ 29 ] who demonstrated that HFHC in experimental diets will cause lipid accumulation in some organs, especially the liver. C. nutans attenuated the HFHC induced changes without apparent toxicity to other organs, as seen from the organ weights index in Table 3 .…”

A Preliminary Study on the Effect of Psyllium Husk Ethanolic Extract on Hyperlipidemia, Hyperglycemia, and Oxidative Stress Induced by Triton X-100 Injection in Rats

“…Serum leptin concentration in triton-induced hyperlipidemic rats increased versus CON rats. Leptin is formed by adipose tissue as fat packing reserves in the body, and it adjusts food consumption and energy disbursement [ 49 ], thus, indicating that the elevated serum leptin levels detected are likely a consequence of the increased fat accumulation. The leptin level reduced in hyperlipidemic rats that received PHEE in contrast to hyperlipidemic rats.…”

Bauhiniastatin-1 alleviates diet induced obesity and lipid accumulation through modulating PPAR-γ/AMPK expressions: In-vitro, in-vivo and in-silico studies.

“…It is authenticated by taxonomist in the department of Botany, Sri Venkateswara University, Tirupati, voucher number is 136 and specimen was preserved in departmental herbarium. The bark of B. purpurea was powdered, extracted with ethanol and further fractionated by column chromatography using different solvents [12]. The collected fractions were subjected to LC-MS analysis on 6520 Accurate Q-TOF (Agilent Santa Clara, CA) mass spectrometer to identify the major compounds.…”

“…of BSTN1 was suspended in 0.5% carboxymethylcellulose (CMC) and orally administered for 6 weeks from 13th week onwards using an intra-gastric tube. We selected these concentrations based on our initial pilot studies using solvent extracts [12]. IAEC approval (No:55/2012/(i)/a/CPCSEA/IAEC/SVU/MBJ, dated: 8-7-2012) were followed to conduct the animal experiments.…”

“…In our previous study, we reported the anti-hyperlipidemic activity of bark extract of Bauhinia purpurea Linn. [12]. In the present study, we have made an attempt to isolate and purify the active principle, Bauhiniastatin-1, evaluated its anti-NAFLD and anti-obesity activity and underlying molecular mechanisms using diet induced obese rat model.…”