Antiobesity and Anti‐Inflammatory Effects of Orally Administered Bonito Extracts on Mice Fed a High‐Fat Diet

Ikebe, Emi; Fife-Koshinomi, Nichole; Matsumoto, Takashi; Yahiro, Takaaki; Ikebe, Taichi; Iha, Hidekatsu

doi:10.1155/2017/9187167

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…The experiments on mice were conducted as per our previous study [21]. Briefly, eight-week-old male C57BL6/J mice were fed a standard diet and kept under the specific-pathogen-free (SPF) conditions.…”

Section: Methodsmentioning

confidence: 99%

Long-Term Potable Effects of Alkalescent Mineral Water on Intestinal Microbiota Shift and Physical Conditioning

Yahiro

Hara

Matsumoto

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Background An alkalescent (pH 8.3) mineral water (AMW) of Hita basin, located in the northwestern part of Kyushu island in Japan, has been recognized for the unique quality of ingredients including highly concentrated silicic acid, sodium, potassium, and hydrogen carbonate. The biological effects of AMW intake were evaluated with a particular focus on its “antiobesity” properties through its modulation of the gut microbiota population. Methods Two groups of C57BL6/J mice (8-week-old male) were maintained with a standard diet and tap water (control: TWC group) or AMW (AMW group) for 6 months and the following outputs were quantitated: (1) food and water intake, (2) body weight (weekly), (3) body fat measurements by CT scan (monthly), (4) sera biochemical values (TG, ALT, AST, and ALP), and (5) UCP-1 mRNA in fat tissues (terminal point). Two groups of ICR mice (7-week-old male) were maintained with the same method and their feces were collected at the 0, 1st, 3rd, and 6th month at which time the population rates of gut microbiota were quantitated using metagenomic sequencing analysis of 16S-rRNA. Results Among all antiobesity testing items, even though a weekly dietary consumption was increased (p=0.012), both ratios of weight gain (p=1.21E − 10) and visceral fat accumulation (p=0.029) were significantly reduced in the AMW group. Other criteria including water intake (p=0.727), the amounts of total (p=0.1602), and subcutaneous fat accumulation (p=0.052) were within the margin of error and UCP-1 gene expression level (p=0.171) in the AMW group was 3.89-fold higher than that of TWC. Among 8 major gut bacteria families, Lactobacillaceae (increased, p=0.029) and Clostridiaceae (decreased, p=0.029) showed significant shift in the whole population. Conclusion We observed significantly reduced (1) weight gaining ratio (average −1.86%, up to −3.3%), (2) visceral fat accumulation ratio (average −4.30%, up to −9.1%), and (3) changes in gut microbiota population. All these consequences could support the “health benefit” functionality of AMW.

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Section: Methodsmentioning

confidence: 99%

Long-Term Potable Effects of Alkalescent Mineral Water on Intestinal Microbiota Shift and Physical Conditioning

Yahiro

Hara

Matsumoto

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…Dried bonito broth (DBB), a traditional Japanese food containing abundant histidine [ 18 ], has been reported to reduce the blood levels of inflammatory cytokines (interleukin (IL)-5, -6, and -13) in humans [ 19 ]. Moreover, in our previous animal study, the ingestion of DBB decreased aggressiveness, increased latency, and decreased the number of attacks of resident mice when an intruder was introduced into the home cage [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Nutritional Intervention with Dried Bonito Broth for the Amelioration of Aggressive Behaviors in Children with Prenatal Exposure to Dioxins in Vietnam: A Pilot Study

Nishijo

Pham

Duong³

et al. 2021

Nutrients

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Dioxins have been suggested to induce inflammation in the intestine and brain and to induce neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), partly due to deficits in parvalbumin-positive neurons in the brain that are sensitive to inflammatory stress. Previously, we reported ADHD traits with increased aggressiveness in children with prenatal exposure to dioxins in Vietnam, whereas dried bonito broth (DBB) has been reported to suppress inflammation and inhibit aggressive behavior in animal and human studies. In the present study, we investigated the association between dioxin exposure and the prevalence of children with highly aggressive behaviors (Study 1), as well as the effects of DBB on the prevalence of children with highly aggressive behaviors (Study 2). Methods: In Study 1, we investigated the effects of dioxin exposure on the prevalence of children with high aggression scores, which were assessed using the Children’s Scale of Hostility and Aggression: Reactive/Proactive (C-SHARP) in dioxin-contaminated areas. The data were analyzed using a logistic regression model after adjusting for confounding factors. In Study 2, we performed nutritional intervention by administering DBB for 60 days to ameliorate the aggressiveness of children with high scores on the C-SHARP aggression scale. The effects of DBB were assessed by comparing the prevalence of children with high C-SHARP scores between the pre- and post-intervention examinations. Results: In Study 1, only the prevalence of children with high covert aggression was significantly increased with an increase in dioxin exposure. In Study 2, in the full ingestion (>80% of goal ingestion volume) group, the prevalence of children with high covert aggression associated with dioxin exposure was significantly lower in the post-ingestion examination compared with in the pre-ingestion examination. However, in other ingestion (<20% and 20–79%) groups and a reference (no intervention) group, no difference in the prevalence of children with high covert aggression was found between the examinations before and after the same experimental period. Conclusions: The findings suggest that DBB ingestion may ameliorate children’s aggressive behavior, which is associated with perinatal dioxin exposure.

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Nutritional Interventions in Treating or Ameliorating Aggression with Dietary Regimes and Protocols

Nishijo¹,

Nishijo²,

Nishimaru³

2022

Handbook of Anger, Aggression, and Violence

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Antiobesity and Anti‐Inflammatory Effects of Orally Administered Bonito Extracts on Mice Fed a High‐Fat Diet

Cited by 4 publications

References 39 publications

Long-Term Potable Effects of Alkalescent Mineral Water on Intestinal Microbiota Shift and Physical Conditioning

Long-Term Potable Effects of Alkalescent Mineral Water on Intestinal Microbiota Shift and Physical Conditioning

Nutritional Intervention with Dried Bonito Broth for the Amelioration of Aggressive Behaviors in Children with Prenatal Exposure to Dioxins in Vietnam: A Pilot Study

Nutritional Interventions in Treating or Ameliorating Aggression with Dietary Regimes and Protocols

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