Antiobesity effect of Lactobacillus reuteri 263 associated with energy metabolism remodeling of white adipose tissue in high-energy-diet-fed rats

Chen, Li Han; Chen, Yi Hsing; Cheng, Kuan Chen; Chien, Ting Yi; Chan, Ching Hung; Tsao, Shu Ping; Huang, Hui Yu

doi:10.1016/j.jnutbio.2017.11.004

Cited by 62 publications

(35 citation statements)

References 63 publications

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“…Ninety per cent of diabetes cases are T2DM, which is caused by several factors, such as ROS, inflammation, lipid metabolism imbalance, and obesity [ 31 ]. Therefore, some functional foods that could decrease these factors were also reported to attenuate T2DM [ 32 , 33 , 34 , 35 ]. Although TGPE has not revealed an effect of diabetes modulation, its propolin components were found to increase the antioxidant cytokines SOD and GPx and decrease ROS [ 9 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Taiwanese Green Propolis Ethanol Extract Delays the Progression of Type 2 Diabetes Mellitus in Rats Treated with Streptozotocin/High-Fat Diet

et al. 2018

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Taiwanese green propolis ethanol extract (TGPE) is produced only in Taiwan and has a different composition from other types of propolis. TGPE is known for its anti-inflammation, anti-oxidation, and anti-microbial properties, but the effects and mechanisms of TGPE in the modulation of diabetes are unclear. In this study, we investigated the effects of TGPE on type 2 diabetes mellitus (T2DM) in a streptozotocin/high-fat-diet (STZ/HFD)-induced T2DM rat model. The results revealed that TGPE delayed the development and progression of T2DM and reduced the severity of β-cell failure. TGPE also attenuated inflammation and reactive oxygen species ROS in the rats. Moreover, there were higher levels of oxidant cytokines, leptin, and adiponectin in the serum of the TGPE-treated group. Unlike Brazilian propolis, TGPE promoted hepatic genes PPAR-α and CYP7A1, which were related to lipid catabolism and removal. TGPE may thus delay the progression of T2DM through anti-inflammation effects, anti-oxidation effects, and balancing lipid metabolism. It is suggested that TGPE can be a potential alternative medicine for T2DM.

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Section: Discussionmentioning

confidence: 99%

Taiwanese Green Propolis Ethanol Extract Delays the Progression of Type 2 Diabetes Mellitus in Rats Treated with Streptozotocin/High-Fat Diet

et al. 2018

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“…Inflammation and free radical levels are both correlated with the speed of aging [ 7 , 8 ] and therefore probiotic supplements may be a feasible treatment option owing to their diverse effects, namely anti-inflammatory activities [ 9 ], antioxidant activities [ 10 ], and metabolic regulation [ 11 ]. Recent studies have also suggested that probiotics use the gut–brain axis to increase the levels of neural monoamines, such as dopamine (DA), serotonin (5-HT), and brain-derived neurotropic factor (BDNF), which are critical for neuronal plasticity and survival [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus paracasei PS23 Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice

et al. 2018

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Probiotic supplements are potential therapeutic agents for age-related disorders due to their antioxidant and anti-inflammatory properties. However, the effect of probiotics on age-related brain dysfunction remains unclear. To investigate the effects of Lactobacillus paracasei PS23 (LPPS23) on the progression of age-related cognitive decline, male and female senescence-accelerated mouse prone 8 (SAMP8) mice were divided into two groups (n = 6 each): the control and PS23 groups. From the age of 16 weeks, these groups were given saline and LPPS23, respectively, because SAMP8 mice start aging rapidly after four months of age. After 12 weeks of treatment, we evaluated the effect of LPPS23 by analyzing their appearance, behavior, neural monoamines, anti-oxidative enzymes, and inflammatory cytokines. The PS23 group showed lower scores of senescence and less serious anxiety-like behaviors and memory impairment compared to the control group. The control mice also showed lower levels of neural monoamines in the striatum, hippocampus, and serum. Moreover, LPPS23 induced the anti-oxidative enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx). Higher levels of tumor necrosis factor (TNF)-α and monocyte chemotactic protein-1 (MCP1) and lower levels of interleukin (IL)-10 indicated that LPPS23 modulated the inflammation. Our results suggest that LPPS23 supplements could delay age-related cognitive decline, possibly by preventing oxidation and inflammation and modulating gut–brain axis communication.

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“…Notably, high-dose GML significantly increased Lactobacillus reuteri compared to the medium-dose GML. Lactobacillus reuteri has recently been shown to have an important role in the prevention against obesity (34), systemic low-grade inflammation (35) and insulin resistance in mice (36), the improvement of MetS and the production of aryl hydrocarbon receptor ligand in the intestine of mice (37). This production plays a vital role in the improvement of intestinal barrier function and secretion of the incretin hormone Glucagon-Like Peptide (GLP)-1 (37).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial emulsifier – glycerol monolaurate impacts gut micobiome inducing distinct effects on metabolic syndrome in low-fat diet fed mice

Jiang

Xiao

Zhang

et al. 2020

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Previous study demonstrated 150 mg·kg-1 glycerol monolaurate (GML) consumption induced gut microbiota dysbiosis and metabolic syndrome (MetS) in low-fat diet fed mice. However, little is known about the dose-effect of dietary GML modulating the gut microbiome alterations and its impacts on the induction of MetS in low-fat diet. Dietary GML-induced effects on MetS and gut microbiota alterations were investigated, combined with antibiotics-treated germ-free experiment and specific gut microbiota transplantation. Our results demonstrated that high-dose (500 mg·kg-1) GML alleviated MetS by significantly decreasing the body weight, weight gain, food intake, fat droplet size and percentage of abdominal fat, serum triglycerides (TG), LDL, LPS, TNF-α and atherogenic index, compared to the medium-dose (150 mg·kg-1) GML. Importantly, high-dose GML significantly increased Lactobacillus reuteri compared to the medium-dose GML. Co-occurrence network analysis revealed Lactobacillus reuteri was positively associated with the metabolic improvement of high-dose GML. Notably, antibiotics-treated germ-free experiment and Lactobacillus reuteri transplantation demonstrated that altered gut microbiota was necessary and sufficient for GML-induced distinct effects on metabolic syndrome. Our results indicate that GML impacts gut microbiome inducing distinct effects on metabolic syndrome, thereby calling for reassessing the safe dosage of GML and other non-specific antibacterial food additives.

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Antiobesity effect of Lactobacillus reuteri 263 associated with energy metabolism remodeling of white adipose tissue in high-energy-diet-fed rats

Cited by 62 publications

References 63 publications

Taiwanese Green Propolis Ethanol Extract Delays the Progression of Type 2 Diabetes Mellitus in Rats Treated with Streptozotocin/High-Fat Diet

Taiwanese Green Propolis Ethanol Extract Delays the Progression of Type 2 Diabetes Mellitus in Rats Treated with Streptozotocin/High-Fat Diet

Lactobacillus paracasei PS23 Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice

Antimicrobial emulsifier – glycerol monolaurate impacts gut micobiome inducing distinct effects on metabolic syndrome in low-fat diet fed mice

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