Antiobesity effect of Tamarindus indica L. pulp aqueous extract in high-fat diet-induced obese rats

Abstract

Obesity and overweight are associated with atherosclerosis, fatty liver, hyperlipemia, diabetes mellitus, and various types of cancer. The global prevalence of overweight and obesity has reached epidemic proportions. Here, we investigated the effect of Tamarindus indica pulp aqueous extract (TIE) in diet-induced obese Sprague-Dawley rats. The animals were divided into five groups and labeled as follows: the normal control (NC) group received normal diet; the positive control (PC) group received high-fat diet; and the TIE 5, 25, and 50 groups, after the induction of obesity via a high-fat diet, received TIE at 5, 25, or 50 mg/kg orally for 10 weeks. It was observed that TIE decreased the levels of plasma total cholesterol, low-density lipoprotein (LDL), and triglyceride, and increased high-density lipoprotein (HDL), with the concomitant reduction of body weight. Moreover, TIE decreased plasma leptin and reduced fatty acid synthase (FAS) activity and enhanced the efficiency of the antioxidant defense system. TIE exhibits antiobesity effects, as indicated by a significant reduction in adipose tissue weights, as well as lowering the degree of hepatic steatosis in the obesity-induced rats. The extract possesses hepatoprotective activity, as it reversed the plasma liver enzymes level elevation prior to the high-fat diet. In conclusion, TIE improved obesity-related parameters in blood, liver, and adipose tissue in a rat model and suppressed obesity induced by a high-fat diet, possibly by regulating lipid metabolism and lowering plasma leptin and FAS levels. A dose-dependant effect of TIE is detected, where TIE at 50 mg/kg showed the most prominent effect, followed by TIE at 25 mg/kg and, subsequently, 5 mg/kg.

Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice

“…It is known to be rich in polyphenolics such as rutin, quercetin, and 1-deoxynojirimycin (DNJ). Therefore, it has been used in traditional medicine to treat several metabolic diseases including dyslipidemia (Azman et al 2012), diabetes (Flores et al 2012), fatty liver disease (Ou et al 2011), and hypertension (Kobayashi et al 2006). The mulberry leaf also enhances antioxidant enzyme activities in diabetic rats (Ha et al 2012).…”

Six-Month Chronic Toxicity Study of Tamarind Pulp (Tamarindus indica L.) Water Extract

“…Tamarind pulp water extract has an anti-obesity effect in high fat–induced rats [3] and high carbohydrate–induced rats [16]. Research showed that tamarind pulp water extract decreased LDL levels and triglyceride levels [3].…”

“…Research showed that tamarind pulp water extract decreased LDL levels and triglyceride levels [3]. Finna et al showed that tamarind pulp water extract has an anti-obesity effect in a high carbohydrate–induced diet at the dose of 75 mg/kg bw [16].…”

“…Tamarind pulp water extract has an anti-obesity effect in high fat–induced rats or high carbohydrate–induced rats. Tamarind pulp water extract decreases total cholesterol, low density lipoprotein (LDL), and triglyceride levels [3]. Tamarind pulp contains a considerable amount of polyphenols and flavonoids and shows antioxidant activity [4].…”

Therapeutic Impact of Berries (Morus Alba and Morus Rubra) Fruit Extract in the Regression of High-Fat Diet-Induced Cardiac Dysfunction in Rats

“…It is rich in polyphenolic compounds including rutin, quercetin, and 1-deoxynojirimycin (DNJ). Hence, it has been medicated several diseases including dyslipidemia [7], diabetes [8], fatty liver [6], and hypertension diseases [8]. Besides, the mulberry fruits induce enzymatic antioxidant in diabetic models [8].…”