Antiobesity efficacy of asiatic acid: down-regulation of adipogenic and inflammatory processes in high fat diet induced obese rats

Uddandrao, V. V. Sathibabu; Rameshreddy, P.; Parim, Brahmanaidu; Ponmurugan, P.; Balakrishnan, Santhanaraj; Ramavat, Ravindar Naik; Swapna, K.; Palaniyandi, Suresh S.; Nemani, Harishankar; Meriga, Balaji; Vadivukkarasi, S.; Nivedha, P. R.; Saravanan, G.

doi:10.1080/13813455.2018.1555668

Cited by 30 publications

(24 citation statements)

References 41 publications

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“…The release of free fatty acids is proportional to their levels in coronary sinus. Although these fatty acid molecules are used by the heart in the form of energy sources, excessive deposition of these molecules often leads to triglyceride synthesis that causes hypertriglyceridemia (Balaji et al., 2017; Uddandrao et al., 2019). Lipolysis is also one of the important determinants of ISO‐induced myocardial injury.…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative stress is caused by either overproduction of ROS, due to stress, environmental factors, lifestyle changes, etc., or due to inadequate cellular antioxidant levels in various biological systems. The endogenous antioxidant enzyme defense system plays a significant role in scavenging the ROS in tissue injury and in maintaining cellular integrity by their reducing properties (Sathibabu Uddandrao et al, 2018Uddandrao et al, , 2019. Superoxide dismutase, catalase, and GPx form the first-line cellular defense system present in a biological system to scavenge free radicals in oxidative damage by decomposing hydrogen peroxide and superoxide radicals (Griendling & FitzGerald, 2003).…”

Section: Discussionmentioning

confidence: 99%

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Phenolic fraction extracted from Kedrostis foetidissima leaves ameliorated isoproterenol‐induced cardiotoxicity in rats through restoration of cardiac antioxidant status

Pavithra¹,

Uddandrao²,

Chandrasekaran³

et al. 2020

J. Food Biochem.

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Cardiovascular disease (CVD) is the most common cause of global mortality and morbidity (Huiyao, Jiayin, & Chaoxiang, 2019; Saranya & Padma, 2018), and it has been estimated to affect up to 23.3 million individuals by 2030 (Hui et al., 2017). CVD refers to blood vessel and heart disorders, including coronary artery disease (CAD), elevated blood pressure, stroke, congenital heart defects, and congestive heart failure. Elevated generation of reactive oxygen species (ROS) leads to severe oxidative stress on the myocardium, which predisposes an individual to CVD, including congestive heart failure, ischemic heart disease, and atherosclerosis (Wattanapitayakul & Bauer, 2001). Myocardial infarction (MI) is caused by a critical imbalance between the oxygen supply and the demand for the myocardium, which

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Phenolic fraction extracted from Kedrostis foetidissima leaves ameliorated isoproterenol‐induced cardiotoxicity in rats through restoration of cardiac antioxidant status

Pavithra¹,

Uddandrao²,

Chandrasekaran³

et al. 2020

J. Food Biochem.

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“…Both asiatic acid and its derivatives seem to be promising agents for the future treatment of different diseases (Lv et al, 2018). A wide range of preclinical studies have revealed the anti-inflammatory (Dong et al, 2017), antioxidant (Qi et al, 2017), antidiabetic (Zhang et al, 2009;Frias et al, 2011), hepatoprotective (Gao et al, 2017), neuroprotective (Jiang et al, 2016), antiobesity (Uddandrao et al, 2019), and antimicrobial (Liu et al, 2015) properties of asiatic acid. Furthermore, diverse research teams have suggested that asiatic acid could have beneficial effects in the management and/or prevention of cancers (Islam et al, 2019), epilepsy (Wang et al, 2018), Parkinson's (Ding et al, 2018) and Alzheimer's (Ahmad et al, 2019) diseases, neuropathy (Lou et al, 2018), osteoporosis (Huang et al, 2019), metabolic syndrome (Sharma et al, 2018), and other conditions.…”

Section: Introductionmentioning

confidence: 99%

Asiatic Acid, a Natural Compound that Exerts Beneficial Effects on the Cystometric and Biochemical Parameters in the Retinyl Acetate-Induced Model of Detrusor Overactivity

et al. 2021

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Scientists have been constantly looking for new synthetic and natural compounds that could have beneficial effects in bladder overactivity. Our attention was drawn by asiatic acid that influences a number of molecules and signaling pathways relevant for the proper functioning of the urinary tracts in humans. In the present project we wanted to check whether asiatic acid would have positive effects in the confirmed animal model of detrusor overactivity (DO) and whether it would affect the bladder blood flow, urothelium thickness, inflammatory and oxidative stress markers, neurotrophic and growth factors, and other parameters important for the activity of the urinary bladder. The outcomes of our study showed that a 14-day administration of asiatic acid (30 mg/kg/day) by oral gavage normalizes the cystometric parameters corresponding to DO and reduces the accompanying oxidative stress (measured by the levels of malondialdehyde–61,344 ± 24,908 pg/ml vs. 33,668 ± 5,071 pg/ml, 3-nitrotyrosine–64,615 ± 25,433 pg/ml vs. 6,563 ± 1,736 pg/ml, and NOS2–2,506 ± 411.7 vs. 3,824 ± 470.1 pg/ml). Moreover, it decreases the urinary secretion of neurotrophins (BDNF–304.4 ± 33.21 pg/ml vs. 119.3 ± 11.49 pg/ml and NGF–205.5 ± 18.50 vs. 109.7 ± 15.94 pg/ml) and prevents the changes in a range of biomarkers indicating the dysfunction of the urinary bladder, CGRP (421.1 ± 56.64 vs. 108.1 ± 11.73 pg/ml), E-Cadherin (773.5 ± 177.5 pg/ml vs. 1,560 ± 154.5 pg/ml), OCT3 (3,943 ± 814.6 vs. 1,018 ± 97.07 pg/ml), SNAP-23 (6,763 ± 808.9 pg/ml vs. 3,455 ± 554.5 pg/ml), SNAP-25 (2,038 ± 162.7 pg/ml vs. 833.3 ± 65.48), substance P (171.7 ± 16.86 pg/ml vs. 65.07 ± 8.250 pg/ml), SV2A (1,927 ± 175.3 pg/ml vs. 1,154 ± 254.9 pg/ml), tight junction protein 1 (360.1 ± 95.05 pg/ml vs. 563.4 ± 65.43 pg/ml), VAChT (16,470 ± 2,419 pg/ml vs. 7,072 ± 1,339 pg/ml), VEGFA (318.3 ± 37.89 pg/ml vs. 201.5 ± 22.91 pg/ml). The mentioned parameters are associated with smooth muscle contractions, urothelial barrier, transportation and release of transmitters, or bladder compensation. Thus, the presented findings allow to suggest a possible future role of asiatic acid in the prevention of conditions accompanied by DO, such as overactive bladder.

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“…Asiatic acid has shown anti-diabetic and anti-obesity activities by enhancing insulin secretion and reducing the production of fatty acids in adipose tissue, respectively. The effect of asiatic acid on body weight is connected to its ability to inhibit the activity of pancreatic lipase and amylase, thereby driving weight loss [ 125 ]. Asiatic acid has been reported to exhibit anti-diabetic activities by inhibiting the production of free radicals linked to the development of diabetes embryopathy, nephropathy, and neuropathy [ 95 , 126 , 127 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Diabetic Potential of Plant-Based Pentacyclic Triterpene Derivatives: Progress Made to Improve Efficacy and Bioavailability

et al. 2021

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Diabetes mellitus (DM) results from the inability of the pancreas to produce sufficient insulin or weakened cellular response to the insulin produced, which leads to hyperglycemia. Current treatments of DM focus on the use of oral hypoglycemic drugs such as acarbose, alpha-glucose inhibitors, sulphonylureas, thiazolidinediones, and biguanides to control blood glucose levels. However, these medications are known to have various side effects in addition to their bioavailability, efficacy, and safety concerns. These drawbacks have increased interest in the anti-diabetic potential of plant-derived bioactive compounds such as oleanolic and maslinic acids. Although their efficacy in ameliorating blood glucose levels has been reported in several studies, their bioavailability and efficacy remain of concern. The current review examines the anti-diabetic effects of oleanolic, maslinic, asiatic, ursolic, and corosolic acids and their derivatives, as well as the progress made thus far to enhance their bioavailability and efficacy. The literature for the current review was gathered from leading academic databases—including Google Scholar and PubMed—the key words listed below were used. The literature was searched as widely and comprehensively as possible without a defined range of dates.

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Antiobesity efficacy of asiatic acid: down-regulation of adipogenic and inflammatory processes in high fat diet induced obese rats

Cited by 30 publications

References 41 publications

Phenolic fraction extracted from Kedrostis foetidissima leaves ameliorated isoproterenol‐induced cardiotoxicity in rats through restoration of cardiac antioxidant status

Phenolic fraction extracted from Kedrostis foetidissima leaves ameliorated isoproterenol‐induced cardiotoxicity in rats through restoration of cardiac antioxidant status

Asiatic Acid, a Natural Compound that Exerts Beneficial Effects on the Cystometric and Biochemical Parameters in the Retinyl Acetate-Induced Model of Detrusor Overactivity

Anti-Diabetic Potential of Plant-Based Pentacyclic Triterpene Derivatives: Progress Made to Improve Efficacy and Bioavailability

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