Antiobesity Potential and Complex Phytochemistry of Momordica charantia Linn. with Promising Molecular Targets

Karale, Pushpa; Dhawale, Shashikant C.; Karale, Mahesh

doi:10.36468/pharmaceutical-sciences.681

Cited by 4 publications

(2 citation statements)

References 56 publications

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“…There is evidence that several plant-based polyphenols have the ability to neutralize free radicals and have anti-inflammatory, hypoglycemic, and anti-infertility effects (Karale et al, 2020). With a range of side effects and drug resistance, herbal therapy may be a viable alternative.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Clinacanthus nutans (Burm. F.) Leaf Extract on Sperm Quality and Antioxidant Activity in Male Mice Induced with Streptozotocin

Abdulwahid-Kurdi

2024

JBRA

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Objective: Clinacanthus nutans (C. nutans) is a medicinal herb that most people with diabetes have historically taken. It's a diet high in antioxidants, which are supposed to help people live longer and be healthier.It is the first study to suggest using C. nutans to enhance the quality of sperm in male mice given a streptozotocin (STZ) injection.Methods: Sixty mice were divided into two groups at the age of four weeks: group one was fed a regular diet (n=10), while group two was administered a high-fat diet (n=50) for eight weeks to develop obesity. Obese mice were given 100mg/kg of STZ to produce hyperglycemia with a 20% mortality rate. Then, 40 hyperglycemic mice were separated into two groups: STZ (n=10) and sample (n=30). The treatment groups were administered a methanolic extract of C. nutans leaves by gavage at doses of 150, 300, and 500mg/kg of body weight (n=10) for 4 weeks.Results: In contrast to the STZ group, there was a substantial (p=0.001) drop in serum blood glucose and total sperm abnormalities in mice at varying doses. Catalase, glutathione s-transferase (GST), and total antioxidant capacity significantly (p=0.001) increased in the STZ mice group at varying doses, but malondialdehyde was reduced. In comparison to STZ mice, testosterone and luteinizing hormone (LH) levels improved in mice treated with extracts of C. nutans at various doses. For all of the following dependent variables, extraction of the leaf at higher concentrations of 500 milligrams/kilogram has better efficacy than 300 and 150 mg/kg after 4 weeks of treatment.Conclusions: The research and development of new natural agents to combat oxidative stress-related diseases have sparked a lot of interest. As a result, the potential leaf extract of C. nutans contains anti-hyperglycemic compounds and improves the quality of sperm in male mice.

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Section: Introductionmentioning

confidence: 99%

The Impact of Clinacanthus nutans (Burm. F.) Leaf Extract on Sperm Quality and Antioxidant Activity in Male Mice Induced with Streptozotocin

Abdulwahid-Kurdi

2024

JBRA

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“…In India, China, Japan and other Asian countries, M. charantia, grown as a valuable vegetable crop. Previous research has shown that the plant has antibacterial, antiviral, antidiabetic, antifertility, abortifacient, anti-ulcer and antimalarial properties, as well as immunomodulatory properties [15] . Psoralea corylifolia (P. corylifolia) (Leguminosae) is a popular herb used in traditional Indian and Chinese herbal medicine to treat skin diseases.…”

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confidence: 99%

Quantitative Phytochemical Profile, Antioxidant and Lipase Inhibitory Potential of Leaves of Momordica charantia L. and Psoralea corylifolia L

Karale¹,

Dhawale²,

Karale³

2022

IJPS

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Medicinal plants have recently gained popularity and are now commonly used to treat a variety of diseases. The aim of this research was to evaluate antioxidant and anti-lipase activities of two commonly used medicinal plants in vitro. The solvents like chloroform, acetone and 70 % ethanol were used to extract the dried leaves of Momordica charantia and Psoralea corylifolia. Folin-Ciocateu's reagent and the aluminum chloride colorimetry process were used to determine the total phenolic and flavonoid contents, respectively. Further the extracts were screened for in vitro antioxidant activity, analyzed by 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity and ferric reducing antioxidant power assay. Using pancreatic lipase enzyme inhibition, the anti-lipase potential of extracts was studied and compared to that of the reference drug orlistat. The phytochemical analysis revealed that the ethanol extract of Momordica charantia had the highest total phenolic and total flavonoid content (89.96±0.29 mg gallic acid equivalents/g of dry extract; 82.55±0.03 mg quercetin equivalents/g of dry extract, respectively) of all the plant extracts examined. The ethanol extract of Momordica charantia exhibited substantial radical scavenging and ferric reducing potential, with IC 50 values of 96.85±0.04 μg/ml and 99.43±0.06 μg/ml, respectively. Anti-lipase activity was found in all of the extracts. The ethanol extract of Momordica charantia, on the other hand, demonstrated strong anti-lipase activity, with an IC 50 value of 27.70±0.15 μg/ml (p< 0.01). The standard drug orlistat (18.15±0.34 μg/ml) showed the greatest anti-lipase activity. Overall, Momordica charantia leaf extracts exhibited greater antioxidant and anti-lipase activity than Psoralea corylifolia. Momordica charantia and Psoralea corylifolia were found to be powerful antioxidants and pancreatic lipase inhibitors. A daily supplement of these plants, according to our findings, can aid in the reduction of obesity.

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A comprehensive LCMS/MS characterization for the green extracted cucurbitane-triterpenoid glycosides from bitter melon (Momordica charantia) fruit

Ahmad,

Aldholmi,

Alqathama

et al. 2024

Food Chemistry

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Antiobesity Potential and Complex Phytochemistry of Momordica charantia Linn. with Promising Molecular Targets

Cited by 4 publications

References 56 publications

The Impact of Clinacanthus nutans (Burm. F.) Leaf Extract on Sperm Quality and Antioxidant Activity in Male Mice Induced with Streptozotocin

The Impact of Clinacanthus nutans (Burm. F.) Leaf Extract on Sperm Quality and Antioxidant Activity in Male Mice Induced with Streptozotocin

Quantitative Phytochemical Profile, Antioxidant and Lipase Inhibitory Potential of Leaves of Momordica charantia L. and Psoralea corylifolia L

A comprehensive LCMS/MS characterization for the green extracted cucurbitane-triterpenoid glycosides from bitter melon (Momordica charantia) fruit

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