Antiovulatory and Anti-Implantation Potential of the Methanolic Extract of Seeds of Abrus Precatorius in the Rat

Okoko, Ini-Ibehe Essien; Osinubi, AA; Olabiyi, Olaleye O.; Kusemiju, T.O.; Noronha, CC; Okanlawon, A O

doi:10.4158/ep09011.or

Cited by 20 publications

(11 citation statements)

References 22 publications

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“…Literature survey of the cited plants confirmed that Abrus precatorius (Ross, 2005;Okoko et al, 2010), Acalypha indica (Hafez, 1970;Shivayogi et al, 1999), Ailanthus excelsa (Ravichandran et al, 2007), Ananas comosus (Bhaduri et al, 1968;Garó et al, 1970;Näf-Müller and Willhalm, 1971), Aristolochia bracteolata (Natraj et al, 2007), Azadirachta indica (Riar et al, 1991;Sinha et al, 1984a,b), Bambusa vulgaris (Yakubu and Bukoye, 2009), Embelia ribes (Radhakrishnan and Alam, 1975;Garg and Garg, 1978;Prakash, 1981), Hibiscus rosa-sinensis (Pakrashi et al, 1986;Vasudeva and Sharma, 2008), Plumbago zeylanica (Premakumari et al, 1977;Chowdhury et al, 1982;Edwin et al, 2009), Vicoa indica (Dhall and Dogra, 1988;Rao et al, 1996) potent antifertility effects.…”

Section: Discussionsupporting

confidence: 57%

“…Various African tribes use AP powdered seeds as oral contraceptives (Watt and Breyer-Brandwijk, 1962). AP possesses different pharmacological activities including antifertility (Ross, 2005), anti-implantation (Okoko et al, 2010), antimicrobial (Adelowotan et al, 2008), antitumor (Ghosh and Maiti, 2007), immunopotentiating (Ramnath et al, 2002) and sperm antimotility. Zia-ul-Haque et al (1983b) reported the post-coital (days 2-5) antifertility (100% sterility) effect of abridine, isolated constituent from AP, when administered p.o.…”

Section: Abrus Precatorius Linn (Family: Fabaceae)mentioning

confidence: 98%

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Potential antifertility agents from plants: A comprehensive review

Kumar

Prakash

2012

Journal of Ethnopharmacology

123

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Section: Discussionsupporting

confidence: 57%

Section: Abrus Precatorius Linn (Family: Fabaceae)mentioning

confidence: 98%

Potential antifertility agents from plants: A comprehensive review

Kumar

Prakash

2012

Journal of Ethnopharmacology

123

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“…Elevated level of progesterone during pregnancy plays a key role in maintaining the conditions and is an important factor in the implantation process. Therefore, luteolysis and reduction in the blood levels of progesterone may contribute to abortion and anti-implantation activity of the all extracts [27][28][29][30][31][32]. The findings of present study were agreed with previous studies which reported the effect of Inula viscoseand Bambusa vulgarisleaf extract on implantation and abortion in rats and rabbits (Yakubu and Bukoye, 2009).…”

Section: Acute Oral Toxicitysupporting

confidence: 90%

Pharmacological Evaluation and Antifertility Activity of Aloe barbadensis Linn on female wistar rats.

Shah¹,

Jhade²,

Chouksey³

2017

ijpm

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Ethanolic and Aqueous extract of Leaf of Aloe barbadensiswas study, antifertility activity in proven fertile female Wistar Rats at the doses 500mg/kg b.wt./day for 30 days. Different parameters were studied in female wistar rats including effect of Reproductive outcome, Anti-implantation, Abortifacient study and Estrogenic and Anti-estrogenic activity, Phytochemical were observed.,Aloe vera Leaves shown positive test for Alkaloids, Steroid, Flavonoids, Terpene, Carbohydrates and Tannin. The extract of Aloe vera has anti-fertility effect the control rats showed good number of litters. Treatment of animal with different extracts, resulted a significant (P< 0.05, P< 0.01). antifertility activity (42.2% and 7.8%) was exhibited by AAV and WAV respectively. After 21 days of the extracts free period, the antifertility effect of the extracts was reversed. The extract treatments with AAV, an increase in the resorption index (%) by the extract is an indication of failure in the development of the embryo. The mean percentage of anti-implantation and percent resorption (abortifacient) were found to be highest for AAV-29.46%, WAV -12.17, and AAV-32.96%, WAV-7.78% respectively. The decrement in implantation caused by the extracts may be due to estrogenic or anti-estrogenic activity. However, along with standard AAVexhibiting more potent estrogenic and less potent anti-estrogenic when compared with standard.Clinical assessment of Female antifertility agents should include acceptability, safety and efficacy during and after the treatment. The present study was therefore carried out to evaluate the claimed antifertility effect of Aloe veraleaf using different aspects of reproductive physiology in female wistar rats.

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“…precatorius seed extract also caused reversible alterations in the estrous cycle pattern and completely blocked ovulation in Sprague-Dawley rats 7 . A methanolic extract of the plant produced dose-dependent bronchodilator activity in a guinea pig model 8 .…”

mentioning

confidence: 88%

Untitled

2013

IJPSR

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ABSTRACT:The crude methanol extracts of aerial parts of Abrus precatorius L., leaf of Magnolia pterocarpa Roxb. and Dracaena spicata Roxb. and leaf and bark of Ravenala madagascariensis Sonn. as well as their hexane, carbon tetrachloride, chloroform and aqueous soluble partitionates were subjected to screenings for thrombolytic and membrane stabilizing activities. Among the extractives of A. precatorius, the crude methanol extract exhibited the highest thrombolytic activity (34.92±0.54 %) while the carbon tetrachloride soluble fraction of M. pterocarpa

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Antiovulatory and Anti-Implantation Potential of the Methanolic Extract of Seeds of Abrus Precatorius in the Rat

Cited by 20 publications

References 22 publications

Potential antifertility agents from plants: A comprehensive review

Potential antifertility agents from plants: A comprehensive review

Pharmacological Evaluation and Antifertility Activity of <em>Aloe </em><em>barbadensis</em> Linn on female wistar rats.

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