Antioxidant Action andIn VivoAnti-Inflammatory and Antinociceptive Activities ofMyrciaria floribundaFruit Peels: Possible Involvement of Opioidergic System

Abstract

This work evaluated the antioxidant properties and in vivo antinociceptive and anti-inflammatory effects of extracts obtained from fruit peels of Myrciaria floribunda (H. West ex Willd.) O. Berg (Myrtaceae). This plant is popularly known in Brazil as Cambuí or camboim. Different extracts were submitted to comparative analysis to determine the content of selected phytochemical classes (levels of total phenols, flavonoids, and monomeric anthocyanins) and the in vitro antioxidant potentials. The extract with higher potential was selected for in vivo evaluation of its antinociceptive and anti-inflammatory action. Finally, the chemical characterization of this extract was performed by high-performance liquid chromatography (HPLC). MfAE (extract obtained using acetone as solvent) showed the higher levels of phenols (296 mg GAE/g) and anthocyanins contents (35.65 mg Cy-3-glcE/g) that were associated with higher antioxidant activity. MfAE also exhibited in vivo anti-inflammatory and analgesic propertiers. This fraction inhibited the inflammatory and neurogenic phases of pain, and this effect was reversed by naloxone (suggesting the involvement of opioidergic system). MfAE reduced the abdominal contortions induced by acetic acid. The HPLC analysis revealed the presence of gallic acid (and its derivatives) and ellagic acid. Taken together, these data support the use of M. floribunda fruit peels for development of functional foods and nutraceutics.

Chemical Composition and Variability of the Volatile Components of Myrciaria Species Growing in the Amazon Region

“…Myrciaria floribunda (H. West ex Willd.) O. Berg is known elsewhere as rumberry, camboim, and cambuí, growing naturally in the Central and South American continents [ 21 , 22 ]. Their fruits contain rutin, phenolic acids, and β-cryptoxanthin (pro-vitamin A) and are consumed in nature as jelly and in distilled beverages [ 23 ].…”

Phytochemical and biological investigations of extracts from the roots of Cocos nucifera L. (Arecaceae) and Carica papaya L. (Caricaceae), two plants used in traditional medicine

“…Antioxidants are substances that prevent various pathologic changes in living cell by protecting oxidation of its major constituents (proteins, lipids, carbohydrates and DNA) (Moualek et al, 2016). Phenolic compounds are considered the most antioxidant metabolites from plants; and these compounds have the ability to give hydrogen or electrons Da Silva Santos et al, 2020).…”

Cambuí (Myrciaria floribunda (West ex Willd.) O. Berg): A potential nutritional supplement for inhibition of COVID-19 infections / Cambuí (Myrciaria floribunda (West ex Willd.) O. Berg): Um potencial suplemento nutricional para a inibição de infecções por COVID-19

“…Brazilian Journal of Development, Curitiba, v.8, n.2, p. 11975-11987 feb. 2022. Santos et al, (2020) reported the presence of 62.28 (mg GAE/g) of total phenolic compound in the cambuí extract obtained using water under room pressure. However, the study reported above did not find flavonoid contents (mg QE/g) in the cambuí aqueous extract (Santos et al, 2020).…”

“…Santos et al, (2020) reported the presence of 62.28 (mg GAE/g) of total phenolic compound in the cambuí extract obtained using water under room pressure. However, the study reported above did not find flavonoid contents (mg QE/g) in the cambuí aqueous extract (Santos et al, 2020). Hence, we can suggest that the use of water under high pressure in the first step of extraction provides the obtaining relevant amount of flavonoid contents and other phenolic compounds, as can be seen in table 1.…”

“…They can be consumed raw, or processed for the production of juices, jellies, or fermented products. Cambuí fruit is rich in vitamin C (129.43 mg of ascorbic acid/100 g) (Sirqueira Nascimento, Muniz and Cruz Silva, 2020), and contains high concentrations of phenolic compounds such as flavonoids (Santos et al, 2020).…”