Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats

Abstract

Tinospora cordifolia is widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus. Oral administration of 2.5 g and 5.0 g/kg body weight of the aqueous extract of the roots for 6 weeks resulted in a significant reduction in thiobarbituric acid reactive substances (TBARS) and an increase in reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in alloxan diabetic rats. The effect of Tinospora cordifolia root extract (TCREt) was most prominently seen in the case of rats given 5.0 g/kg body weight. The effect of TCREt was more effective than glibenclamide. Thus our study shows that TCREt exhibits antioxidant action in alloxan diabetes.

Protective Effects of Mustard Leaf (Brassica juncea) against Diabetic Oxidative Stress

“…The associations among TBA-reactive substances, diabetes, and diabetic complications have been well es tablished. Increased concentrations of TBA-reactive substances have been observed in the plasma, livers and kidneys of diabetic rats and humans (44)(45)(46)(47). Con sistent with these reports, in our present study, the serum, liver and kidney TBA-reactive substance levels were elevated in diabetic rats as compared to normal rats ( Table 4).…”

Restoration of antioxidant defence by ethanolic Tinospora cordifolia root extract in alloxan‐induced diabetic liver and kidney

“…We have shown that oral administration of aqueous TCREt exhibits hypoglycaemic and antioxidant action in alloxanized rats (Stanely Mainzen Prince and Menon, 2000;Stanely Mainzen Prince and Menon, 2001). In the present study, we report the effect of ethanolic TCREt on TBARS, GSH, SOD and catalase in alloxan diabetic liver and kidney.…”

Comparative study to evaluate the anti-diabetic activity of commercially available extract of Tinospora cordifolia and Phyllanthus emblica in streptozocin induced diabetic rat

“…18 In a study with alloxan induced rats aqueous TC root extract resulted in increased activity of hexokinase in the liver leading to increase glycolysis and increase utilization of glucose in peripheral tissues. 19 Hyperglycemia induced oxidative stress have been suggested as a mechanism for insulin resistance. Antioxidants like vitamin C, vitamin D and glutathione improves insulin sensitivity in diabetes.…”