Antioxidant Actions of β-Carotene in Liposomal and Microsomal Membranes: Role of Carotenoid-Membrane Incorporation and α-Tocopherol

Liebler, Daniel C.; Stratton, Steven P.; Kaysen, Kathryn L.

doi:10.1006/abbi.1996.9822

Cited by 76 publications

(37 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While this is significantly lower than the 70-90% entrapment shown using chloroform, it is encouraging that between 40-50% of the added β-carotene can be incorporated in the liposome membrane using a food-safe solvent. However, due to previously mentioned problems regarding the removal of aggregated β-carotene, the concentrations of β-carotene used in these experiments are very low compared with those seen in the literature [2,6,10,11,18,22,24,25] or those that would be required for most food applications.…”

Section: β-Carotene Entrapmentmentioning

confidence: 96%

Comparison of hydrophobic and hydrophilic encapsulation using liposomes prepared from milk fat globule-derived phospholipids and soya phospholipids

Thompson

Couchoud

Singh

2009

Dairy Sci. Technol.

View full text Add to dashboard Cite

-Liposomes prepared from a milk fat globule membrane (MFGM) phospholipid fraction have been shown to have significantly different physical and chemical characteristics and appeared to be more stable in a variety of conditions than liposomes prepared from soya phospholipid material. These liposome systems were used to try to encapsulate model hydrophobic (β-carotene) and hydrophilic (potassium chromate) compounds. Liposomes produced from the MFGM-derived phospholipids showed significantly higher entrapment efficiencies for both β-carotene and potassium chromate. The differences were particularly apparent when using the hydrophobic molecules at low ratios of β-carotene to phospholipid. It is likely that the improved incorporation efficiency for β-carotene is due to the partitioning of the molecule between the aqueous phase and the phospholipid membrane, a property which will be dependent on the specific composition of the phospholipid material used. The higher encapsulation efficiency for the potassium chromate appeared to reflect the slightly larger diameter of the liposomes produced from the MFGM material. These results suggest that there may be inherent advantages in the use of liposomes prepared from MFGM-derived phospholipids via microfluidization for the encapsulation of both hydrophobic and hydrophilic compounds.

show abstract

Section: β-Carotene Entrapmentmentioning

confidence: 96%

Comparison of hydrophobic and hydrophilic encapsulation using liposomes prepared from milk fat globule-derived phospholipids and soya phospholipids

Thompson

Couchoud

Singh

2009

Dairy Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…The combination of α -tocopherol and β -carotene has been reported to act cooperatively as well to slow down MDA formation initiated by the aqueous peroxyl radical, AAPH, in a liver microsomal membrane preparation (Palozza and Krinsky 1992b ). β -Carotene added to preformed lipid bilayers produced much less of an antioxidant effect than β -carotene incorporated in the liposomes during bilayer formation (Liebler et al 1997 ). It is possible that α -tocopherol reduces β -carotene peroxyl radicals (LOO -β -C -OO • ) as well as β -carotene radical cations ( β -C • + ), as has been shown in a homogeneous solution (Mortensen and Skibsted 1997 ).…”

Section: Biological Significance Of Antioxidant Interactionsmentioning

confidence: 99%

Antioxidant Activity and Oxidative Stress: An Overview

Yeum

Russell

Aldini

2010

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

View full text Add to dashboard Cite

“…The ability of beta-carotene in liposomes to inhibit free radical mediated lipid peroxidation appears, however, to be much lower than that of alpha-tocopherol (27). Betacarotene at 0.45 mol% (of phospholipid) is, however, a more powerful inhibitor of singlet oxygen mediated lipid peroxidation than alpha-tocopherol at 0.45 mol% (28).…”

Section: Lipid Soluble Antioxidantsmentioning

confidence: 99%

Liposome Delivery of a Potential Antidote for Mustard Exposure. An Overview and Integration of Data for Phase One Experiments by the Mustard Consortium, Regarding the Use of Antioxidants as a Counter Measure to Mustard

Hill¹

2000

View full text Add to dashboard Cite

Antioxidant Actions of β-Carotene in Liposomal and Microsomal Membranes: Role of Carotenoid-Membrane Incorporation and α-Tocopherol

Cited by 76 publications

References 32 publications

Comparison of hydrophobic and hydrophilic encapsulation using liposomes prepared from milk fat globule-derived phospholipids and soya phospholipids

Comparison of hydrophobic and hydrophilic encapsulation using liposomes prepared from milk fat globule-derived phospholipids and soya phospholipids

Antioxidant Activity and Oxidative Stress: An Overview

Liposome Delivery of a Potential Antidote for Mustard Exposure. An Overview and Integration of Data for Phase One Experiments by the Mustard Consortium, Regarding the Use of Antioxidants as a Counter Measure to Mustard

Contact Info

Product

Resources

About