Antioxidant Activities and Chemical Constituents of Extracts from Cordyline fruticosa (L.) A. Chev. (Agavaceae) and Eriobotrya japonica (Thunb) Lindl, (Rosaceae)

Abstract

Background and Objective: Cordyline fruticosa (Agavaceae) and Eriobotrya japonica (Rosaceae) are two medicinal plants used for the treatment of various diseases such as infections of mammary glands, sore throat and neck pain for the first plant, diabetes, cough, ulcers, protection against oxidative stress and cognitive deficits for the latter. The present study was designed to evaluate the antioxidant activity of the different extracts of these two plants as well as to isolate and identify their chemical constituents. Materials and Methods: The plant extract was prepared by maceration in methanol, compounds were isolated from EtOAc and n-BuOH extracts of the two plants using column chromatography and their structures were determined by means of NMR and MS analysis as well as in comparison with published data. Antioxidant tests (DPPH, ferric reduction antioxidant power and anti-hemolytic) were performed over the MeOH, EtOAc and n-BuOH extracts of the plants. Results: The antioxidant-guided phytochemical investigation of the MeOH extracts of the two plants led to the isolation of twelve compounds identified as: Farrerol 1, quercetin helichrysoside 2, apigenin 8-C-β-D-glucopyranoside 3, isoquercitrin 4 and rutin 5 from C. fruticosa, β-sitosterol 6, catechin 7, oleanolic acid 8, lyoniresinol 9, cinchonain IIb 10, lyoniresinol 2-a-O-β-D-xylopyranoside 11 and β-sitosterol-3-O-β-D-glucopyranoside 12 from E. japonica. Amongst the isolated compounds, the most important antioxidant ones were identified as helichrysoside and rutin from C. fruticosa, catechin, cinchonain IIb, lyoniresinol 2-a-O-β-D-xylopyranoside from E. japonica with EC50 of 8.73, 9.91, 4.11, 3.14 and 10.61 μg mL–1, respectively. Conclusion: Based on the obtained results, it can be concluded that the high ability to scavenge free radicals, reducing power of Fe3+ and hemolysis activity exerted by extracts of C. fruticosa and E. japonica were due to their high content of phenolic compounds, thus the structure-activity relationships of the isolated flavonoids were discussed. The results of this study suggest that the extracts from these two plants could serve as potential source of antioxidant compound

Green synthesis of silver nanoparticles using five varieties of Cordyline fruticosa sp. leaves and reviewing their antimicrobial, antioxidant and photocatalytic properties

“…(2) Results show that activity of AgNPs is higher than the water extracts, which is also in line with the findings of higher amounts of TFC, TPC and TAC in AgNPs from this study. Similar studies have shown significant DPPH scavenging activity for methanolic extracts of Cordyline fruticosa leaves (Tapondjou et al, 2016).…”

“…100% Water extracts and AgNP solutions were prepared and 2mL of 0.16mM DPPH solution was added. Mixtures were incubated in the dark for 15 minutes (Tapondjou et al, 2016). Absorbance was measured at 517nm using methanol as the blank.…”

Antiplatelet and Anticoagulant Effects of Two New Phenylpropanoid Sucrose Esters and Other Secondary Metabolites from the Aerial Part of Canna edulis

“…However, their effects were significantly lower than the positive controls in both cases (p < 0.05). In addition, 5 was found to have antihypertensive, [46] antihemolytic, [47] antioxidant, [47,48] glucose tolerance-improving activity, [49] and inhibitory effect on amyloid-β aggregation. [48] The new compound 2 mildly inhibited platelet aggregation for both agonists.…”

Cucumis metuliferus L. Fruits Extract with Antioxidant, Anti-Inflammatory, and Antidiabetic Properties as Source of Ursolic Acid

“…Samples for NMR (nuclear magnetic resonance) experiments were performed in deuterated solvent, CD 3 OD, and analyzed using a Varian mercury-plus spectrometer, 400 MHz for 1 H. 1 H chemical shifts were reported in parts per million (ppm), while the coupling constant (J) was Hertz (Hz) (Figures S1-S3, Supplementary Materials) [48].…”