Antioxidant activities of some common ingredients of traditional chinese medicine, Angelica sinensis, Lycium barbarum and Poria cocos

Wu, Sue-Jing; Ng, Lean‐Teik; Lin, Chun‐Ching

doi:10.1002/ptr.1617

Cited by 120 publications

(80 citation statements)

References 22 publications

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“…In support of a role for the anti-oxidant properties of Lycium barbarum (Amagase et al, 2009b;Wu et al, 2004;Gong et al, 2005) in the attenuation of the effects of exercise on cortisol release are the results of Davison, et al (2007). Similar to the current results, they showed that dietary supplementation with anti-oxidants (daily vitamin C (L-ascorbic acid, 1000 mg) and vitamin E (RRR-alpha-tocopherol, 400 IU) supplementation) blunted the cortisol response to a single prolonged exercise challenge (Davison et al, 2007).…”

Section: Discussionsupporting

confidence: 84%

Lycium barbarum Fruit (Goji) Attenuates the Adrenal Steroid Response to an Exercise Challenge and the Feeling of Tiredness: A Randomized, Double-blind, Placebo-controlled Human Clinical Study

Amagase¹,

Nance²

2012

JFR

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We examined the effects of Lycium barbarum fruit (goji) intake on general well-being in a randomized, double-blind, placebo-controlled 30-day intervention trial. Plasma levels of cortisol, dehydroepiandrosterone (DHEA), glucose, urea nitrogen (BUN) and lactic acid followed by an exercise challenge were assessed at the pre-and post-intervention. Relative to the placebo group (n=19), tiredness and overall health were significantly improved in the Lycium barbarum group (n=20). Cortisol, DHEA and lactic acid levels were significantly increased by the exercise for the pre-intervention: However, at the post-intervention, Lycium barbarum intake significantly attenuated cortisol and DHEA levels. Lactic acid levels were comparable for both groups, and glucose and BUN levels were not altered. These results show that Lycium barbarum consumption attenuates the adrenal steroid response and reduces the feeling of tiredness.

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Section: Discussionsupporting

confidence: 84%

Lycium barbarum Fruit (Goji) Attenuates the Adrenal Steroid Response to an Exercise Challenge and the Feeling of Tiredness: A Randomized, Double-blind, Placebo-controlled Human Clinical Study

Amagase¹,

Nance²

2012

JFR

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“…14) Our previous study also proved that pretreatment with LBP (200 mg/kg), the main antioxidant in Lycium barbarum, significantly attenuated DOX-induced cardiac myofibrillar disarrangement in rats. LBP was also effective in decreasing the levels of serum CK to improve conduction abnormalities caused by DOX exposure.…”

Section: Discussionmentioning

confidence: 78%

Electrocardiographic and Biochemical Evidence for the Cardioprotective Effect of Antioxidants in Acute Doxorubicin-Induced Cardiotoxicity in the Beagle Dogs

Xin

Zhang

et al. 2011

Biological & Pharmaceutical Bulletin

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Doxorubicin (DOX), a quinone-containing anthracycline antineoplastic, is used for the treatment of solid and hematopoietic tumors. However, its dose-dependent cardiotoxicity hampered its clinical application.1) Recent studies have suggested that DOX-induced cardiotoxicity involves the formation of reactive oxygen species (ROS) and amplification of mitochondrial dysfunction.1,2) Moreover, the anticancer effects of DOX do not follow the identical mechanisms of ROS. The majority of strategies to protect cardiomyocytes against DOX-induced oxidative injury in heart therefore focused on administering antioxidants in the past. 1)A number of antioxidants, such as lycopene, N-acetylcysteine and vitamin E were proved to ameliorate the DOXinduced cardiac cell damage without compromising its antitumor efficacy in the rats or mice model. [3][4][5] However, most of them were tried with limited success in preventing DOX-associated cardiotoxicity in large-sized animals such as dogs or pigs. 6)Lycium barbarum, a famous Chinese medicinal herb, has a long history of use as an antioxidant and to promote sexual fertility. Lycium barbarum polysaccharides (LBP), consisting of various botanic polysaccharide including arabinose, rhamnose, xylose, mannose, galactose and glucose, are the most important functional constituents in red-colored fruits Lycium barbarum. LBP and edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one, a potent free radical scavenger, EDA) were found to elicit a typical cardioprotective effect against DOXrelated oxidative stress in rats. 7,8) However, no similar cardioprotective effect of either LBP or EDA was reported in beagle dogs. Electrocardiography (ECG) is one of the standard methods used to assess cardiac function and is often performed to evaluate whether cardioprotective agents would improve DOX-induced conduction abnormalities.9,10) Moreover, the usefulness of biochemical indicators such as serum creatine kinase (CK) and aspartate aminotransferase (AST) in assessment of DOX-associated cardiotoxicity in experimental animals has also been indicated by various studies. 11)The present study aims to explore electrocardiographic and biochemical evidence for the cardioprotective effect of those two antioxidants in DOX-induced acute cardiotoxicity in beagle dogs. MATERIALS AND METHODSChemicals DOX was obtained from Pfizer Italia S.r.l. (Nerviano, Italy) as a 10 mg/bottle lyophilized powder. It was dissolved in 20 ml of 0.9% saline for injection. Lycium Chinese mill Polysaccharide was purchased from Zhejiang Doxorubicin (DOX) is a potent antitumor agent, but the cardiotoxicity mediated by the formation of reactive oxygen species limit its clinical use. The present study aims to explore electrocardiographic and biochemical evidence for the cardioprotective effect of two antioxidants, Lycium barbarum polysaccharides (LBP, the main antioxidant in Lycium barbarum) and edaravone (a potent free radical scavenger, EDA) against DOX-induced acute cardiotoxicity in beagle dogs. In this study, male beagle dogs received daily treat...

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“…22) Compound 2 was obtained as sticky oil with small amount. Its molecular formula was determined as C 23 13 C-NMR and DEPT spectra showed two aromatic rings with carbon signals for 9 methines, 2 methylenes, 5 methyls, and 7 quaternary carbons, which supported that the extra degree of unsaturation except two phenyl rings was presumed to be due to tetrahydrofuran ring. The 8.8Ј-linked tetrahydrofuran skeleton between two propanyl groups was certified by good connectivities in the 1 H-1 H COSY spectrum, which showed correlations between H-8 with H-7/H-9/H-8Ј and H-8Ј with H-7Ј/H-9Ј/H-8.…”

mentioning

confidence: 85%

Two New Stereoisomers of Neolignan and Lignan from the Flower Buds of Magnolia fargesii

Lee

Seo

Jang

et al. 2009

CHEMICAL & PHARMACEUTICAL BULLETIN

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Antioxidant activities of some common ingredients of traditional chinese medicine, Angelica sinensis, Lycium barbarum and Poria cocos

Cited by 120 publications

References 22 publications

Lycium barbarum Fruit (Goji) Attenuates the Adrenal Steroid Response to an Exercise Challenge and the Feeling of Tiredness: A Randomized, Double-blind, Placebo-controlled Human Clinical Study

Lycium barbarum Fruit (Goji) Attenuates the Adrenal Steroid Response to an Exercise Challenge and the Feeling of Tiredness: A Randomized, Double-blind, Placebo-controlled Human Clinical Study

Electrocardiographic and Biochemical Evidence for the Cardioprotective Effect of Antioxidants in Acute Doxorubicin-Induced Cardiotoxicity in the Beagle Dogs

Two New Stereoisomers of Neolignan and Lignan from the Flower Buds of <i>Magnolia fargesii</i>

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