Antioxidant activities of some Lamiaceae plant extracts

Erdemoğlu, N.; Turan, Nilüfer N.; Cakici, I; Şener, Bilge; Aydın, Ahmet

doi:10.1002/ptr.1816

Cited by 99 publications

(55 citation statements)

References 37 publications

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“…[1,2] Oxidation processes are also deleterious in human health, since they induce tissue damage responsible for several pathologies, including cancer, neurodegenerative and ischaemic heart diseases, malaria, arteriosclerosis and other pathological conditions. [3] The utilization of antioxidants can prevent food oxidation or cell damage. To prevent this degradation process of lipids, the food industry adds antioxidants of low cost and high stability, mostly synthetic ones, such as butylated hydroxyanisol (BHA), butylated hydroxytoluene (BHT), gallats, and tert-butylhydroquinone (TBHQ), in well-defi ned concentrations.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity of six Portuguese thyme species essential oils

Dandlen

Lima

Mendes

et al. 2010

Flavour & Fragrance J

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The essential oils of Thymus caespititius, T. camphoratus, T. capitellatus, T. carnosus, T. pulegioides, T. zygis subsp. zygis and T. zygis subsp. sylvestris collected in diff erent regions of Portugal, including the Azores islands, were evaluated for preventing lipid peroxidation and scavenging free radicals, and hydroxyl and superoxide anions. T. zygis subsp. zygis oil possessed the best capacity for preventing lipid peroxidation (IC 50 = 0.030 ± 0.003 mg/ml), immediately followed by the oils isolated from T. zygis subsp. sylvestris collected in diff erent regions of Portugal. IC 50 values ranged from 0.066 ± 0.003 to 0.087 ± 0.001 mg/ml in oils isolated from samples from Alcanena and Duas Igrejas, respectively. The oils isolated from T. zygis subsp. sylvestris, independent of the harvesting region, were shown to be the most eff ective for scavenging free radicals (0.358-0.453 mg/ml). The best capacity for scavenging hydroxyl radicals was found in the oils of T. camphoratus collected in Espartal and of T. caespititius of Lordelo, with IC 50 < 0.5 mg/ml. The low oil amount did not allow IC 50 values for the superoxide anion scavenging determination, therefore considering a unique oil concentration (5 mg/ml), the highest inhibition percentages (>50%) were registered with the essential oils of T. zygis subsp. sylvestris from Duas Igrejas and Covão do Coelho, and of T. capitellatus from Sines.

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Section: Introductionmentioning

confidence: 99%

Antioxidant activity of six Portuguese thyme species essential oils

Dandlen

Lima

Mendes

et al. 2010

Flavour & Fragrance J

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“…Medicinal plants and herbs are diverse sources of natural antioxidants. Therefore, there is a great interest concerning the antioxidant properties of medicinal plants and herbs (Velioglu et al, 1998;Cakir et al, 2003Cakir et al, , 2006Ismaili et al, 2004;Sokmen et al, 2004;Salehi et al, 2005;Erdemoglu et al, 2006;Ozgen et al, 2006). This study was undertaken to determine the potential antimicrobial, antioxidant, and free radical scavenging activities of the extracts of some Turkish native herbs.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Antioxidant Activities of Some Plants Used as Remedies in Turkish Traditional Medicine

Unal

Mavi

Kara

et al. 2008

Pharmaceutical Biology

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The antimicrobial activities of chloroform, acetone, ethanol, and water extracts of 25 plants, mostly used as remedies against various diseases in Turkish traditional medicine, were tested against 10 pathogenic bacteria and one fungus (Candida albicans) using the disk diffusion method. Among the tested plant species, Ziziphora clinopodioides Lam (Labiatae), Thymus fallax Fisch et Mey. (Labiatae), and three Hypericum species [H. heterophyllum Vent., H. hyssopifolium Chaix. subsp. elongatum (Ledeb.) Woron var. elongatum, and H. scabrum L.] (Guttiferae) showed antimicrobial activity at a broader spectrum. In particular, chloroform, acetone, and ethanol extracts of Z. clinopodioides inhibited the growth of all microbial species. Minimal inhibition concentration values of Z. clinopodioides extracts were also found to be low. The antioxidant activity of the acetone, ethanol, and water extracts of 20 plants was also evaluated by lipid peroxidation inhibition and DPPH free radical scavenging methods. It was found that water, ethanol, and acetone extracts of Z. clinopodioides, T. fallax, three Hypericum species, Artemisia santonicum L. (Compositae), and Echinophora tenuifolia L. subsp. sibthorpiena (Umbelliferae) have strong antioxidant activities among the tested plant species. In general, there is a correlation between the antioxidant potential and total phenolic contents of the extracts. In light of the current study, it can be concluded that Z. clinopodioides and T. fallax may have potential use in the food industry as antioxidants and antimicrobial herbs, as well as pharmaceutical interest.

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“…Studies indicate that extracts, fractions and isolated compounds from different medicinal plants have antioxidant effects in the DPPH assay [33,[38][39][40][41][42]. Our results show that the EAF was more effective than other fractions at scavenging DPPH.…”

Section: In Vitro Antioxidant Activitymentioning

confidence: 54%

Antioxidant and Hepatoprotective Effects of Cyathea phalerata Mart. (Cyatheaceae)

Hort

DalBó

Brighente³

et al. 2008

Basic Clin Pharma Tox

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The present study investigated the antioxidant properties of Cyathea phalerata Mart. (Cyatheaceae) using in vitro and in vivo assays. The in vitro antioxidant potential of the crude extract (CE), precipitate (PPT), aqueous fraction (AQF), n-butanolic fraction (BUF) and ethyl acetate fraction (EAF) from C. phalerata was evaluated through the scavenging of diphenyl-1-picryl-hydrazyl-hydrate (DPPH), superoxide anion (O 2• − ) (nitroblue tetrazolium assay) and hydroxyl radicals (OH • ) (deoxyribose assay), and lipid peroxidation in rat liver homogenate. In these assays, it was observed that EAF had marked antioxidant potential, especially as a scavenger of the OH• radical and in inhibiting lipid peroxidation. The in vivo evaluation of oxidative stress (DNA fragmentation, membrane lipoperoxidation and carbonyl protein formation) and the antioxidant defenses (concentration of reduced glutathione, as well as catalase and glutathione S-transferase activities) were measured in mice pre-treated with EAF (10, 30 or 100 mg/kg, orally) and later exposed to carbon tetrachloride (CCl 4 ). The EAF decreased thiobarbituric acid reactive substances levels, DNA damage and carbonyl protein contents, and increased catalase and glutathione S-transferase activities. Based on these results, it is concluded that the EAF from C. phalerata protects liver from oxidative stress induced by CCl 4 in mice and these effects are probably related to the antioxidant activity associated with the free radical scavenging property of this fraction.Cyathea phalerata Mart. (Cyatheaceae) is a tree fern that grows in the tropical and subtropical areas of Brazil and is commonly known as 'xaxim'. In folk medicine, its stem pith is used to treat several inflammatory diseases and the alcohol extract of the pith is used for the treatment of varicose veins and hemorrhoids. In phytochemical studies of Cyathea genus, several classes of compounds were identified such as fernene, filicene and hopane triterpenes [1,2], phenolic acids (coumaric and caffeic), protocatechuic acids and flavonoids, mainly kaempferol glycosides [3][4][5]. In a recent study, Pizzolatti et al . [6] isolated the cyathenosin A, a spiropyranosil derivative of protocatechuic acid, from the stem pith of C. phalerata . Studies on the pharmacological effects of C. phalerata are still limited. However, recently, Cazarolli et al . [7] demonstrated that the flavonoid, kaempferol-3-neohesperidoside, isolated from C. phalerata , has a hypoglycaemic effect in diabetes induced by alloxan in rats.Flavonoids exhibit a wide range of biological effects, including antibacterial, anti-inflammatory, anti-allergic, hepatoprotective, antithrombotic, antiviral, anticarcinogenic and vasodilatory actions; many of these biological functions have been attributed to the free radical scavenging and antioxidant activity of these compounds [8][9][10].Oxidative stress plays an important role in the pathogenesis of several human pathologies, including ischaemia and reperfusion injury, atherosclerosis, neurodegene...

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Antioxidant activities of some Lamiaceae plant extracts

Cited by 99 publications

References 37 publications

Antioxidant activity of six Portuguese thyme species essential oils

Antioxidant activity of six Portuguese thyme species essential oils

Antimicrobial and Antioxidant Activities of Some Plants Used as Remedies in Turkish Traditional Medicine

Antioxidant and Hepatoprotective Effects of Cyathea phalerata Mart. (Cyatheaceae)

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