Antioxidant Activities of the Methanol Extract ofCardiospermum halicacabum.

Abstract

Cardiospermum halicacabum Linn. (Sapindaceae) is a climber, commonly found as a weed throughout India, used as vegetable as well as traditional medicine for rheumatism, lumbago, and nervous diseases and as demulcent in orchitis and in dropsy. In the current study, we investigated the antioxidant potency of methanol extract of C. halicacabum (CHE) employing various established in vitro systems, such as the b-carotene-linoleate model system, 1,1-diphenyl-2-picrylhydrazyl (DPPH)=superoxide= nitric oxide radical scavenging, reducing power, and iron ion chelating activity. CHE showed noticeable inhibitory activity toward b-carotene-linoleate model system. Furthermore, CHE exhibited a moderate concentrationdependent inhibition of DPPH radical. The multiple antioxidant activity of CHE was evident as it also possessed reducing power, superoxide scavenging ability, nitric oxide scavenging activity, and also ferrous ion chelating potency. The data obtained in the in vitro models clearly establish the antioxidant potency of methanol extract of C. halicacabum.

Formulation and evaluation of topical herbal gel for the treatment of arthritis in animal model

“…The anti-inflammatory activity of ethanol extract of CH reported to inhibit LPS induced COX-2, TNF-α and iNOS expression in RAW264.7 cells (Sheeba, Asha, 2009). Experimental pharmacological studies have shown the analgesic and vasodepressant activities (Gopalakrishnan, Dhananjayan, Kameswaran, 1976), anti-pyretic activity against yeastinduced pyrexia in rats (Asha, Pushpangadan, 1999), anti-malarial (Waako et al, 2005), anti-oxidant activity (Kumaran, Karunakaran, 2006), anti-ulcer activity against ethanol induced gastric ulcer in rats (Sheeba, Asha, 2006) and suppression of the production of TNF-α and nitric oxide in human peripheral blood mononuclear cells (Babu, Krishnakumari, 2006). A number of compounds have been isolated and identified in CH, viz.…”

Formulation and Evaluation of Novel Herbal Aerosol for Arthritis

“…Anti-inflammatory properties of CH have been researched [11], but no clinical trials have been reported so far. Experimental pharmacological studies of CH have shown antioxidant activity [12] analgesic and vasodepressant activities [13], antipyretic activity [14], Antimalarial activity [15], diuretic activity [16], anti-diarrheal activity [17], anti-diabetic activity [18] and anti-ulcer activity [19].…”

Review of beneficial and remedial aspects of Cardiospermum halicacabum L.

“…This herb act as a diaphoretic, diuretic, emetic, laxative, refrigerant, stomachic and sudorific and has antibacterial (Dhar et al, 1968;Raman et al, 1998), anti-diarrheal (Rao et al, 2006), antioxidant activities (Kumaran and Karunakaran, 2006), suppresses TNF production (Babu and Krishnakumari, 2006), exhibits anticancer (Sheeba and Asha, 2006), vaso depressant (Gopalakrishnan et al, 1976) effect. This herb is also useful in curing of rheumatism, severe bronchitis and firmness of the appendages and snakebite (Abdulla, 1973;Gopalakrishnan et al, 1976;Nadkarni, 1976;Chopra et al, 1980;Joshi et al, 1992).…”