Antioxidant activity and acetylcholinesterase inhibition of field and in vitro grown Musa L. species

Ayoola, Ibukun O.; Guèye, Badara; Sonibare, Mubo A.; Abberton, Michael T.

doi:10.1007/s11694-016-9416-y

Cited by 13 publications

(19 citation statements)

References 45 publications

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“…In this study, the anticholinesterase activity observed from leaves samples was higher than the fruits. These observations are in line with the results of the previous study by Ayoola et al (). Furthermore, comparing the activity of different fractions revealed that the nonpolar fractions (dichloromethane and n ‐hexane) had little or no anti‐AChE activity, unlike for the polar fractions of both leaves and fruits where fractions with ethyl acetate displayed highest anti‐AChE activity.…”

Section: Discussionsupporting

confidence: 94%

“…It was also discovered that the leaf had a better antioxidant, antidiabetic, and anti‐inflammatory potentials than the fruit. This confirms previous study revealing the better efficiency of leaf extracts in terms of antioxidant activity and total phenolic content, compared to fruit extracts, for all the Musa speies tested (Ayoola et al, ). This suggests that Musa spp.…”

Section: Discussionsupporting

confidence: 92%

“…This confirms previous study revealing the better efficiency of leaf extracts in terms of antioxidant activity and total phenolic content, compared to fruit extracts, for all the Musa speies tested (Ayoola et al, 2017). This suggests that Musa spp.…”

Section: Discussion and Con Clus I On Ssupporting

confidence: 91%

“…The antioxidant activity of all samples was determined by three different methods. The DPPH · assay was done according to the method described by Susanti et al (2007) and Ayoola et al (2017). The ABTS assay was performed and hydroxyl radical scavenging activities were determined using the methods described by Re et al (1999) and Oboh, Puntel, and Rocha (2007), respectively.…”

Section: Antioxidant Assaysmentioning

confidence: 99%

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Isolation of flavonoids from Musa acuminata Colla (Simili radjah, ABB) and the in vitro inhibitory effects of its leaf and fruit fractions on free radicals, acetylcholinesterase, 15‐lipoxygenase, and carbohydrate hydrolyzing enzymes

et al. 2020

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Musa species are used traditionally for the management of many diseases. The study evaluated and compared anticholinesterase, anti‐inflammatory, antioxidant, and antidiabetic activities of Musa acuminata (Simili radjah, ABB) fruits and leaves fractions and characterized the bioactive compounds using HPTLC‐HRMS and NMR. Leaf fractions gave the higher biological activities than the fruit. Ethyl acetate fraction of the leaf had the highest total phenolic content (911.9 ± 1.7 mg GAE/g) and highest 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH·) scavenging activity (IC50, 9.0 ± 0.4 µg/ml). It also gave the most effective inhibition of acetylcholinesterase (IC50, 404.4 ± 8.0 µg/ml) and α‐glucosidase (IC50, 4.9 ± 1.6 µg/ml), but a moderate α‐amylase inhibition (IC50, 444.3 ± 4.0 µg/ml). The anti‐inflammatory activity of n‐butanol (IC50, 34.1 ± 2.6 µg/ml) and ethyl acetate fractions (IC50, 43.1 ± 11.3 µg/ml) of the leaf were higher than the positive control, quercetin (IC50, 54.8 ± 17.1 µg/ml). Kaempferol‐3‐O‐rutinoside and quercetin‐3‐O‐rutinoside (rutin) were identified as the bioactive compounds with antioxidant and antidiabetic activities from the ethyl acetate fraction of M. acuminata leaf. Practical applications All parts of Musa acuminata are known to be useful ethnomedicinally even as food. The leaves are mostly used to serve food and used for wrapping purposes. However, this study concluded that M. acuminata leaf is rich in bioactive flavonoids such as kaempferol‐3‐O‐rutinoside and rutin, with relatively high antioxidative, antidiabetic, and anti‐inflammatory activities. Therefore, aside the fact that the leaves can serve as potential drug leads for pharmaceutical industries, it can also be embraced in the food sector to produce supplements and/or nutraceuticals in the management of Alzheimer's, diabetes and other inflammatory diseases.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Section: Discussion and Con Clus I On Ssupporting

confidence: 91%

Section: Antioxidant Assaysmentioning

confidence: 99%

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Isolation of flavonoids from Musa acuminata Colla (Simili radjah, ABB) and the in vitro inhibitory effects of its leaf and fruit fractions on free radicals, acetylcholinesterase, 15‐lipoxygenase, and carbohydrate hydrolyzing enzymes

et al. 2020

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“…Since diabetes has a multifactorial aetiology, various underlying mechanisms have been investigated. In addition to the ability to inhibit carbohydrate-digesting enzymes (α-glucosidase and α-amylase), the potential of banana phytochemicals to affect, e.g., glucose adsorption (Jaber et al 2013) and/or antioxidant activity (Ayoola et al 2017) have been most frequently described. However, a great deal of further research on the development of phytomedicines as well as edible products with functional properties is needed.…”

mentioning

confidence: 99%

Antidiabetic Compounds in Stem Juice from Banana

Nguyen¹,

Zachariasova²,

Spurna³

et al. 2017

Czech J. Food Sci.

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Nguyen D., Nováková A., Spurná K., Hričko J., Phung H., Viktorová J., Stránská M., Hajšlová J., Ruml T. (2017): Antidiabetic compounds in stem juice from babana grown in natural and greenhouse. Czech J. Food Sci., 35: 407-413.The stem juices from Musa × paradisiaca L. banana plants cultivated in their original natural habitat in Vietnam and those cultivated in a greenhouse in the Czech Republic were investigated for the presence of phytochemicals with antidiabetic potency. Respective bioactivities of these phytochemicals were also determined. Sample screening using ultrahigh performance liquid chromatography coupled with tandem high-resolution mass spectrometry (UHPL-HRMS/MS) method showed some differences in the pattern of bioactive compounds, both in terms of their number and concentration. p-Hydroxybenzoic and gallic acids were the predominant analytes found in stem juice from plants grown in Vietnam, while ferulic acid was the major compound found in juice obtained from greenhouse bananas. Despite differences in the occurrence of potentially antidiabetic compounds, both extracts exhibited comparable inhibitory activity against α-glucosidase and α-amylase.

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Ferula haussknechtii Inhibits Acetylcholinesterase: In‐Vitro and In‐Silico Studies

Babaei,

Ebadi,

Dastan

2023

ChemistrySelect

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Alzheimer's disease (AD) is a destructive neurological disease. Approved therapies that target the cholinergic system to control the symptoms have various complications. Natural compounds that inhibit the acetylcholinesterase (AChE) enzyme can promote the development of new drugs. Nature‐derived compounds are more compatible with biological systems in comparison to synthetic library. Ferula haussknechtii is a native species of Iran. In study, we evaluated the effects of its essential oil and extracts on the inhibition of AChE through in vitro and in silico methods. The essential oil was extracted by Clevenger apparatus. Extracts were prepared by maceration for 72 hours. The Ellman's test was used to measure the inhibitory effects of the samples. The interaction of the main constituents of the essential oil with AChE was investigated by Coarse Grained molecular dynamics (CG‐MD) simulation. Essential oil inhibited the AChE with IC50: 44.6 μg/ml. Among different extracts, hydroalcoholic extract with IC50: 41.4 μg/ml exhibited the most potent inhibitory effect. Based on the results of 1 μs CG‐MD simulation, the major constituents of the essential oil inhibited the AChE by binding to the PAS site. The constituents of F. haussknechtii could be considered as a rich source for discovering and designing new AChE inhibitors.

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Antioxidant activity and acetylcholinesterase inhibition of field and in vitro grown Musa L. species

Cited by 13 publications

References 45 publications

Isolation of flavonoids from Musa acuminata Colla (Simili radjah, ABB) and the in vitro inhibitory effects of its leaf and fruit fractions on free radicals, acetylcholinesterase, 15‐lipoxygenase, and carbohydrate hydrolyzing enzymes

Isolation of flavonoids from Musa acuminata Colla (Simili radjah, ABB) and the in vitro inhibitory effects of its leaf and fruit fractions on free radicals, acetylcholinesterase, 15‐lipoxygenase, and carbohydrate hydrolyzing enzymes

Antidiabetic Compounds in Stem Juice from Banana

Ferula haussknechtii Inhibits Acetylcholinesterase: In‐Vitro and In‐Silico Studies

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