Antioxidant Activity and Anti-Adipogenic Effects of Wild Herbs Mainly Cultivated in Korea

Lee, Young-Jun; Kim, Dan-Bi; Lee, Jong Seok; Cho, Ju-Hyun; Kim, Bong Kyun; Choi, Hyeon‐Son; Lee, Boo-Yong; Lee, Ok‐Hwan

doi:10.3390/molecules181012937

Cited by 62 publications

(45 citation statements)

References 38 publications

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“…9) However, the optimum concentrations and ratios of these hormones for callus induction differ depending on the plant species. [10][11][12] In the current study, auxin (NAA) levels strongly influenced callus induction. When callus induction media included high concentrations of auxin (5.0-25.0 μM NAA), we observed high frequencies of callus induction from all explant sources, regardless of the cytokinin concentration in the medium.…”

Section: Discussionmentioning

confidence: 99%

In vitro plant regeneration of Aster scaber via somatic embryogenesis

Boo

Cao

Pamplona

et al. 2015

Bioscience, Biotechnology, and Biochemistry

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We established an in vitro plant regeneration system via somatic embryogenesis of Aster scaber, an important source of various biologically active phytochemicals. We examined the callus induction and embryogenic capacities of three explants, including leaves, petioles, and roots, on 25 different media containing different combinations of α-naphthalene acetic acid (NAA) and 6-benzyladenine (BA). The optimum concentrations of NAA and BA for the production of embryogenic calli were 5.0 μM and 0.05 μM, respectively. Media containing higher concentrations of auxin and cytokinin (such as 25 μM NAA and 25 μM BA) were suitable for shoot regeneration, especially for leaf-derived calli, which are the most readily available calli and are highly competent. For root induction from regenerated shoots, supplemental auxin and/or cytokinin did not improve rooting, but instead caused unwanted callus induction or retarded growth of regenerated plants. Therefore, plant growth regulator-free medium was preferable for root induction. Normal plants were successfully obtained from calli under the optimized conditions described above. This is the first report of the complete process of in vitro plant regeneration of A. scaber via somatic embryogenesis.

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Section: Discussionmentioning

confidence: 99%

In vitro plant regeneration of Aster scaber via somatic embryogenesis

Boo

Cao

Pamplona

et al. 2015

Bioscience, Biotechnology, and Biochemistry

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“…Successful results have been achieved with the use of certain edible herbal plants and their fruits and berries where, characterized by remarkable antioxidant capacities (oxygen radical absorbance, ORAC) and total phenolic and flavonoid content. Their increased functionality in the human diet is also linked with diverse biological effects, such as anticancer and antimicrobial activities [2,3] . From these fruits and berries, Hippophaes rhamnoides and Lucium barbarum (Goji berry) are widely found in nature/ mountains and cultivated in many countries from South-East Europe to South-East Asia.…”

Section: Botanical Extracts Used As Wine Preservativesmentioning

confidence: 99%

Botanical Extracts Used as Wine Preservatives

Proestos¹

2015

Int J Agric Sc Food Technol

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The aim of the study was to eliminate the potentially harmful sulfite salts normally added to wine -based products for preservation purposes with the introduction into the wine natural products, with pronounced antioxidant activity. Frieze -dried samples taken from the plants Hippophaes and Goji Berry were added to dry white and red wines after their fermentation phase. In all sample tests the sensory and oenological characteristics remained almost unchanged compared to original samples (without the addition of natural products), although their antioxidant activity was significantly increased when leaves of the plant Hippophaes were added. Goji berry fruits and fruit of Hippophaes plant increased antioxidant activity compared to original samples.

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“…54 Quantification of Oil Red O staining in macrophages was determined following solubilizing of lipid droplets in isopropanol and the absorbance was determined at 490 nm. 55 Statistics. All data were analyzed using GraphPad Prism v 6.0 (GraphPad, La Jolla, CA) and Student's t-test (two-tailed with unequal variance) unless otherwise stated.…”

Section: Methodsmentioning

confidence: 99%

Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice

et al. 2018

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We previously demonstrated that protein kinase C-δ (PKCδ) is critical for immunity against Listeria monocytogenes, Leishmania major, and Candida albicans infection in mice. However, the functional relevance of PKCδ during Mycobacterium tuberculosis (Mtb) infection is unknown. PKCδ was significantly upregulated in whole blood of patients with active tuberculosis (TB) disease. Lung proteomics further revealed that PKCδ was highly abundant in the necrotic and cavitory regions of TB granulomas in multidrug-resistant human participants. In murine Mtb infection studies, PKCδ−/− mice were highly susceptible to tuberculosis with increased mortality, weight loss, exacerbated lung pathology, uncontrolled proinflammatory cytokine responses, and increased mycobacterial burdens. Moreover, these mice displayed a significant reduction in alveolar macrophages, dendritic cells, and decreased accumulation of lipid bodies (lungs and macrophages) and serum fatty acids. Furthermore, a peptide inhibitor of PKCδ in wild-type mice mirrored lung inflammation identical to infected PKCδ−/− mice. Mechanistically, increased bacterial growth in macrophages from PKCδ−/− mice was associated with a decline in killing effector functions independent of phagosome maturation and autophagy. Taken together, these data suggest that PKCδ is a marker of inflammation during active TB disease in humans and required for optimal macrophage killing effector functions and host protection during Mtb infection in mice.

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Antioxidant Activity and Anti-Adipogenic Effects of Wild Herbs Mainly Cultivated in Korea

Cited by 62 publications

References 38 publications

In vitro plant regeneration of Aster scaber via somatic embryogenesis

In vitro plant regeneration of Aster scaber via somatic embryogenesis

Botanical Extracts Used as Wine Preservatives

Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice

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