Antioxidant Activity and Anti-Photoaging Effects on UVA-Irradiated Human Fibroblasts of Rosmarinic Acid Enriched Extract Prepared from Thunbergia laurifolia Leaves

Pattananandecha, Thanawat; Apichai, Sutasinee; Julsrigival, Jakaphun; Ungsurungsie, Malyn; Samuhasaneetoo, Suched; Chulasiri, Pat; Kwankhao, Pakakrong; Pitiporn, Supaporn; Ogata, Fumihiko; Kawasaki, Naohito; Saenjum, Chalermpong

doi:10.3390/plants10081648

Cited by 21 publications

(16 citation statements)

References 34 publications

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“…Antioxidant compounds have been shown to have the ability to inhibit the emergence and scavenge of free radicals in a variety of ways [ 1 ]. For example, they block oxidative enzymes, upregulate antioxidant enzymes, and directly respond to free radicals to minimize oxidative damage [ 2 , 3 , 4 ]. Thus, measuring total antioxidant capacity (TAC) is an important indicator expressed with various methods, especially the scavenging activity of free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH • ) and total phenolic content (TPC) [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

A Simple Minimized System Based on Moving Drops for Antioxidant Analysis Using a Smartphone

et al. 2021

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In this paper, a novel antioxidant analysis is proposed using a simple minimized device based on moving drops as solution handling and a smartphone as a detector. This approach is based on the colorimetric determination of the scavenging activity against 2,2-diphenyl-1-picrylhydrazyl radical (DPPH•), expressed as the half-maximal inhibitory concentration (IC50), vitamin C equivalent antioxidant capacity (VCEAC), and Trolox equivalent antioxidant capacity (TEAC). A small drop of the positive control or the samples moves by eluting an ethanol drop down by the force of gravity to react with a DPPH• drop in the detection zone. The color change of DPPH• is monitored by a smartphone camera, and the color signals are processed using Adobe Photoshop software. The magenta-to-yellow ratio was successfully applied to evaluate the percentage of DPPH• inhibition with no significant difference compared with the reference spectrophotometric method at a confidence level of 95%. The total phenolic content (TPC) was measured using the Folin–Ciocalteu assay. An application to Miang (fermented tea leaf extract) showed the consonant relationship between the scavenging activity of DPPH• and TPC.

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Section: Introductionmentioning

confidence: 99%

A Simple Minimized System Based on Moving Drops for Antioxidant Analysis Using a Smartphone

et al. 2021

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“…RA prevents ultraviolet rays-induced photodamage (Gupta et al 2021 ; Huerta-Madroñal et al 2021 ). Pattananandecha et al ( 2021 ) reported anti-oxidant activity and anti-photoaging effects of RA extracts on UVA-mediated damage on human fibroblast from the Thunbergia laurifolia plant. Figure 1 demonstrates RA's anti-inflammatory, anti-oxidant, anti-microbial, anti-diabetic, anti-cancer, and anti-hypertensive potential (Bulgakov et al 2012 ; Zhang et al 2021a ).…”

Section: Introductionmentioning

confidence: 99%

Biomedical features and therapeutic potential of rosmarinic acid

et al. 2022

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For decades, the use of secondary metabolites of various herbs has been an attractive strategy in combating human diseases. Rosmarinic acid (RA) is a bioactive phenolic compound commonly found in plants of Lamiaceae and Boraginaceae families. RA is biosynthesized using amino acids tyrosine and phenylalanine via enzyme-catalyzed reactions. However, the chemical synthesis of RA involves an esterification reaction between caffeic acid and 3,4-dihydroxy phenyl lactic acid contributing two phenolic rings to the structure of RA. Several studies have ascertained multiple therapeutic benefits of RA in various diseases, including cancer, diabetes, inflammatory disorders, neurodegenerative disorders, and liver diseases. Many previous scientific papers indicate that RA can be used as an anti-plasmodic, anti-viral and anti-bacterial drug. In addition, due to its high anti-oxidant capacity, this natural polyphenol has recently gained attention for its possible application as a nutraceutical compound in the food industry. Here we provide state-of-the-art, flexible therapeutic potential and biomedical features of RA, its implications and multiple uses. Along with various valuable applications in safeguarding human health, this review further summarizes the therapeutic advantages of RA in various human diseases, including cancer, diabetes, neurodegenerative diseases. Furthermore, the challenges associated with the clinical applicability of RA have also been discussed.

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“…Quercetin glucoside and quercetin rhamnoside, which are other chemical components of MCB, showed antioxidant effects [ 20 ]. Rosmarinic acid inhibited the production of reactive oxygen species (ROS) in human fibroblast cells induced by ultraviolet A radiation (UVA) [ 21 ]. In the liver, isoquercetin promoted the phosphorylation of acetyl-CoA carboxylase and increased the expression of PPARα and farnesoid X receptor.…”

Section: Introductionmentioning

confidence: 99%

The Antioxidant and Hypolipidemic Effects of Mesona Chinensis Benth Extracts

et al. 2022

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In this study, the antioxidant and hypolipidemic effects of Mesona Chinensis Benth (MCB) extracts were evaluated. Seven fractions (F0, F10, F20, F30, F40, F50 and MTF) were obtained from the MCB ethanol extracts. Compared to the commercial antioxidants (vitamin C), MTF and F30 exhibited higher antioxidant activities in the antiradical activity test and the FRAP assay. The half-inhibition concentration (IC50) for MTF and F30 were 5.323 µg/mL and 5.278 µg/mL, respectively. MTF at 200 µg/mL significantly decreased the accumulation of TG in oleic acid (OA)-induced HepG2 cells and reversed the inhibitory effect of Compound C on AMPK (MTF and F30 significantly increased the glucose utilization of insulin-induced HepG2 cells). In addition, the components of MTF were identified by HPLC-MS, which were caffeic acid, quercetin 3-O-galactoside, isoquercetin, astragalin, rosmarinic acid, aromadendrin-3-O-rutinoside, rosmarinic acid-3-O-glucoside and kaempferol-7-O-glucoside. Through statistical correlations by Simca P software, it was found that the main antioxidant and hypolipidemic components of MCB might be caffeic acid, kaempferol-7-O-glucoside, rosmarinic acid-3-O-glucoside and aromadendrin-3-O-rutinoside, which may play important roles in the AMPK pathway. MTF and F30 in MCB could be potential health products for the treatment of hyperlipidemia.

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Antioxidant Activity and Anti-Photoaging Effects on UVA-Irradiated Human Fibroblasts of Rosmarinic Acid Enriched Extract Prepared from Thunbergia laurifolia Leaves

Cited by 21 publications

References 34 publications

A Simple Minimized System Based on Moving Drops for Antioxidant Analysis Using a Smartphone

A Simple Minimized System Based on Moving Drops for Antioxidant Analysis Using a Smartphone

Biomedical features and therapeutic potential of rosmarinic acid

The Antioxidant and Hypolipidemic Effects of Mesona Chinensis Benth Extracts

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