Antioxidant Activity and Chemical Characteristics of Sambucus nigra L. Blossom from Different Regions in Bulgaria

Gentscheva, Galia; Milkova-Tomova, Iliana; Nikolova, K.; Buhalova, Dragomira; Andonova, Velichka; Gugleva, Viliana; Petkova, Nadezhda; Yotkovska, Ina; Ivanova, N. А.

doi:10.3390/horticulturae8040309

Cited by 11 publications

(8 citation statements)

References 26 publications

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“…The values recorded in the present study are consistent with those reported in other studies published in the scientific literature, namely Tabaszzewska and Sikora [25] reported in their study on composition and antioxidant properties of Sambucus nigra L. extracts, a polyphenol content of 2072.50 mg for the extract obtained from the fresh plant, 619.04 mg for the extract obtained from the frozen plant, 2813.32 mg for the extract obtained from the air-dried plant, and 4070.35 mg for the extract obtained from the lyophilization plant. Mikulic-Petkovsek et al [26] reported for flowers of different elderberry species or interspecific hybrids a total polyphenol content between 7410 and 40,137 mg GAE/kg d.w. and Gentsgevva et al [27] reported a polyphenol content between 299.3 and 49.2 mg GAE/g d.w. Regarding the influence of the extraction method, Horablaga et al [17], who analyzed the influence of the sample preparation/extraction method on the phytochemical profile and antimicrobial activities of 12 commonly consumed medicinal plants, recorded results similar to those reported in the present study, i.e., the highest values being recorded for extracts obtained by microwave, followed by extracts obtained by ultrasound and finally extracts obtained by the conventional method.…”

Section: Antioxidant Profile Determination Of Total Polyphenols Contentmentioning

confidence: 94%

Influence of Extraction Methods on the Phytochemical Profile of Sambucus nigra L.

Floares (Oarga),

Cocan,

Alexa

et al. 2023

Agronomy

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The aim of this work is to evaluate the influence of drying methods, extraction solvent, and extraction methods on the phytochemical profile of Sambucus nigra L. flowers harvested from the western region of Romania. Two drying methods for plant conditioning (room temperature and lyophilization), two extraction solvents (70% ethyl alcohol and water), and three extraction methods (conventional extraction (C), ultrasound-assisted extraction, and microwave extraction) were used. For the evaluation of the phytochemical profile, the following spectrophotometric methods were investigated: total polyphenol content, total antioxidant activity using the DPPH and FRAP methods, and flavonoid content. In addition to the spectrophotometric methods, the individual polyphenols were evaluated using the LC/MS method. Using atomic absorption spectrometry, the macro and microelement content of Sambucus nigra L. flowers was assessed. The results showed that the drying method, the solvent used for extraction, and the extraction method influenced the phytocompound content. The analyses showed that in terms of polyphenols, flavonoid content, and antioxidant activity, high values were recorded for lyophilization-dried samples compared to samples dried at room temperature. Also, higher values were recorded for alcoholic extracts compared to aqueous extracts, but also for extracts obtained by the ultrasound-assisted method, followed by extracts obtained via microwave compared to extracts obtained by conventional extraction.

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Section: Antioxidant Profile Determination Of Total Polyphenols Contentmentioning

confidence: 94%

Influence of Extraction Methods on the Phytochemical Profile of Sambucus nigra L.

Floares (Oarga),

Cocan,

Alexa

et al. 2023

Agronomy

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“…Its medicinal properties are recognized worldwide, and it is included in the pharmacopeias of several countries, including the European pharmacopeia [ 15 ]. Black elder is a deciduous shrub or tree between 4 and 12 m, which is widely distributed across Europe, western and central Asia, northern Africa, and North America [ 16 , 17 , 18 ]. It blooms between May and June with white-cream or greenish-yellow flowers, gathered in flat, complex, umbrella-like umbels [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…Black elder is a deciduous shrub or tree between 4 and 12 m, which is widely distributed across Europe, western and central Asia, northern Africa, and North America [ 16 , 17 , 18 ]. It blooms between May and June with white-cream or greenish-yellow flowers, gathered in flat, complex, umbrella-like umbels [ 17 ]. Fruits are fleshy with a black-purple color and shiny skin.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Anti-Inflammatory and Antinociceptive Activities of Black Elder (Sambucus nigra L.) Fruit and Flower Extracts

Seymenska,

Teneva,

Nikolova

et al. 2024

Pharmaceuticals

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Sambucus nigra L. (S. nigra, SN) or black elder is a traditional medicinal plant widely used worldwide for therapeutic and dietary purposes. The aim of the current study was to investigate the anti-inflammatory and antinociceptive activities of black elder fruit and flower extracts (SNFrE and SNFlE, respectively). The primary polyphenol constituents in the flower extract were flavonoids and phenolic acids, while anthocyanins were the main components in the fruit extract. SNFrE revealed pronounced and dose-dependent in vivo anti-inflammatory activity assessed by the cotton pellet-induced granuloma test. Doses of 10, 20, and 50 mg/kg BW of SNFrE reduced the weight of induced granuloma in rats by 20.3%, 20.5%, and 28.4%, respectively. At the highest dose (50 mg/kg BW), SNFrE had significant (p < 0.01) anti-inflammatory activity comparable to that of diclofenac, the reference compound used (10 mg/kg BW). In addition, the in vivo antinociceptive activity of the extracts in mice was estimated using the acetic-acid-induced writhing test. Both extracts at doses of 50 mg/kg BW inhibited the abdominal contractions induced by the acetic acid significantly comparing to the control group (p < 0.01). Our findings indicate that black elder extracts and particularly SNFrE possess anti-inflammatory and antinociceptive activities, providing experimental evidence for the use of S. nigra in traditional medicine.

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“…The health benefits of the different parts of the S. nigra plant have been investigated by different authors. It has been found that elder flowers are antipyretic, diaphoretic, emetic, expectorant, anti-inflammatory, immunostimulant, antiviral, and antibacterial, while the leaves are disinfectant, diuretic, laxative, purify the blood, and have detoxifying properties [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profiling of Sambucus nigra L. Flower and Leaf Extracts and Their Antimicrobial Potential against Almond Tree Pathogens

Sánchez-Hernández

Balduque-Gil

García

et al. 2023

IJMS

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Despite extensive research on the chemical composition of elderberries and their numerous uses in pharmaceutical, beverage, and food production, there is still a lack of knowledge about Sambucus nigra leaves and flowers’ antimicrobial activity against plant pathogens. In this study, the phytoconstituents of their aqueous ammonia extracts were first characterized by infrared spectroscopy and gas chromatography–mass spectrometry. The major phytocompounds identified in the flower extract were octyl 2-methylpropanoate; 3,5-dihydroxy-6-methyl-2,3-dihydropyran-4-one; propyl malonic acid; adenine; and 1-methyl-2-piperidinemethanol. Concerning the leaf extract, 1,6-anhydro-β-D-glucopyranose; oleic acid; 2,1,3-benzothiadiazole; 2,3-dihydro-benzofuran; and 4-((1E)-3-hydroxy-1-propenyl)-2-methoxyphenol and other phenol derivatives were the main constituents. The potential of the extracts to act as bioprotectants was then investigated against three almond tree pathogens: Diaporthe amygdali, Phytophthora megasperma, and Verticillium dahliae. In vitro tests showed higher activity of the flower extract, with EC90 values in the 241–984 μg·mL−1 range (depending on the pathogen) vs. 354–1322 μg·mL−1 for the leaf extract. In addition, the flower extract led to full protection against P. megasperma at a dose of 1875 μg·mL−1 in ex situ tests on artificially-infected excised almond stems. These inhibitory concentrations were lower than those of commercial fungicides. These findings suggest that S. nigra aerial organs may be susceptible to valorization as an alternative to synthetic fungicides for the protection of this important crop.

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Antioxidant Activity and Chemical Characteristics of Sambucus nigra L. Blossom from Different Regions in Bulgaria

Cited by 11 publications

References 26 publications

Influence of Extraction Methods on the Phytochemical Profile of Sambucus nigra L.

Influence of Extraction Methods on the Phytochemical Profile of Sambucus nigra L.

In Vivo Anti-Inflammatory and Antinociceptive Activities of Black Elder (Sambucus nigra L.) Fruit and Flower Extracts

Phytochemical Profiling of Sambucus nigra L. Flower and Leaf Extracts and Their Antimicrobial Potential against Almond Tree Pathogens

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