Antioxidant activity and chemical composition ofSideritis libanoticaLabill. ssp.linearis(Bentham) Borm. (Lamiaceae)

Abstract

Sideritis libanotica ssp. linearis was screened for the isolation of new natural antioxidant compounds. The antioxidant activity of flavones obtained from the methanol extract of the plant was evaluated in vitro using total antioxidant, reduction power and free radical scavenging activity. Results were compared with the positive controls of antioxidant standards (α-tocopherol and butylated hydroxytoluene). The results indicate that the flavones possess a higher antioxidant activity when compared to the other components in the plant. The lowest antioxidant activity was observed in fatty acids (FAs) and hydrocarbons. The FAs were methylated with MeOH and KOH and analysed by GC-MS. The structures of the isolated compounds were established based on spectroscopic evidence (NMR, GC-MS, HPLC, IR and UV). In this work, the isolated pure flavone (3'-O-methylhypolaetin 7-O-[6″'-O-acetyl-β-D-allopyranosyl-(1 → 2)]-6″-O-acetyl-β-D-glucopyranoside) was found to possess the highest antioxidant activity.

Phytochemical contents, antioxidant effects, and inhibitory activities of key enzymes associated with Alzheimer's disease, ulcer, and skin disorders ofSideritis albifloraandSideritis leptoclada

“…Palmitic acid (14.34%) and oleic acid (13.14%) in S. libanotica ssp. linearis ; capric acid (42.72%) and steric acid (30.64%) in S. taurica ; linolenic acid (77.04 ± 2.07%) and oleic acid (18.83 ± 0.10%) in S. montana were determined as major fatty acids (Aboutabl et al, ; Demirtas et al, ; Emre, Kurşat, & Yılmaz, ).…”

Phytochemical screening, anticancer and antioxidant activities of Origanum vulgare L. ssp. viride (Boiss.) Hayek, a plant of traditional usage

“…It was reported that methanol extracts of Sideritis libanotica ssp. linearis , containing flavonoids, showed significant anticancer activity against three cell lines, namely Vero cells (African green monkey kidney), C6 cells (rat brain tumor) and HeLa cells (human uterus carcinoma) . It was observed that methanol extracts inhibited the proliferation of these cell lines in a dose‐dependent manner (from 25 to 250 µg mL −1 ) .…”

Crystal structure and Hirshfeld surface analysis of 2-oxo-13-epi-manoyl oxide isolated from Sideritis perfoliata

“…Sideritis species include flavonoids, terpenes, iridoids, coumarins, lignanes and sterols that are responsible constituents for their pharmacological properties (Gonzá lez-Burgos et al, 2011). Sideritis species have been reported to exhibit considerable biological activities such as antioxidant (Demirtas et al, 2011), antiproliferative (Demirtas et al, 2009), and antimicrobial (Yig it Hanog lu et al, 2017) effects. The crystal structure of 2--hydroxymanoyl oxide isolated from Sideritis perfoliata has been reported on by our group (Ç elik et al, 2016).…”