Antioxidant activity and free radical-scavenging of cape gooseberry (Physalis peruviana L.) in hepatocellular carcinoma rats model

Abstract

How to cite this article: Hassan HA, Gharib NE, Azhari GF. Antioxidant activity and free radical-scavenging of cape gooseberry (Physalis peruviana L.) in diethylnitrosamine-induced hepatocellular carcinoma. Hepatoma Res 2017;3:27-33.Aim: Oxidative damage of cellular components by free radicals and other reactive oxygen molecules is believed to be associated with the development of degenerative diseases. The aim of the present study was to evaluate the antioxidant capacity and free radical scavenging activity of cape gooseberry juice (CGJ) in diethylnitrosamine-(DENA) and CCl 4 (3 mL/kg b.w.)-induced hepatocellular carcinoma (HCC) rats model. Methods: The rats were divided into 4 groups (6 rats each group). Group 1 (control): the rats of this group did not receive any treatments; group 2 (CGJ): rats were daily administered cape gooseberry juice at a dose of 1 mL/kg b.w.; group 3 (HCC): the rats treated with a single intraperitoneal injection of fresh DENA (200 mg/kg body weight) and received a subcutaneous injection of CCl 4 (3 mL/kg/week); group 4: (HCC + CGJ): rats were treated with DENA (200 mg/kg b.w.) and CCl 4 (3 mL/kg b.w. per week) in addition to daily administered cape gooseberry juice at a dose of 1 mL/kg b.w. Results: Treatment Key words:Oxidative stress, antioxidants, cape gooseberry, diethylnitrosamine ABSTRACT Article history:

Pumpkin seed oil alleviates oxidative stress and liver damage induced by sodium nitrate in adult rats: biochemical and histological approach

“…In parallel, Bouaziz-ketata et al 8 have shown that the administration of NaNO 3 caused a remarkable rise of rat liver MDA contents. Owing to the MDA cytotoxicity and inhibitory action on cellular protective enzymes, it is suggested to act as a tumour promoter 45 .…”

Evaluation of a strawberry fermented beverage with potential health benefits

“…Many human chronic diseases such as cancer, aging, obesity, etc. are believed to be related to the oxidative damage of reactive oxygen species (ROS) to cells ( Hassan, Ghareb & Azhari, 2017 ), the presence of antioxidants (such as total phenol, flavonoids, and SOD) to maintain a dynamic balance between the generation and removal of free radicals in vivo is important. A standard method for assessing the antioxidant capacity of fermented beverages has not been established ( Freire et al, 2017 ).…”

“…During the process of cell metabolism, excessive production of free radicals can cause a series of diseases, such as aging, obesity, arteriosclerosis, etc. ( Hassan, Ghareb & Azhari, 2017 ). Therefore, the balance and stability of free radicals is very important for maintaining the body.…”

Antiproliferative potential of Physalis peruviana-derived magnolin against pancreatic cancer: a comprehensive in vitro and in silico study

“…59 Moreover, in the diethylnitrosamine and CCl 4 -induced hepatocellular carcinoma rat model, the administration of Cape gooseberry juice led to the improvement of hepatic biomarkers. 60 Regarding the antiproliferative potential of pure isolates, reported that 4β-hydroxywithanolide E obtained from the aerial parts of P. peruviana prevented the growth of colon cancer monolayer and spheroid cultures. At low concentrations, the compound induced cell cycle arrest, and at higher concentrations it induced apoptosis.…”