Antioxidant activity and intestinal absorption of apigenin and its potassium salt derivative in Caco-2 cell monolayers

Pérez-Sánchez, Almudena; Sánchez-Marzo, Noelia; Barrajón‐Catalán, Enrique; Castillo, Julián; Herranz-López, María; Micol, Vicente

doi:10.1016/j.freeradbiomed.2017.04.264

Cited by 3 publications

(2 citation statements)

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“…The antioxidant potential of natural compounds also has been reported in several studies [ 34 ]. In the present study, the four constituents we identified in EOE extracts (rosmarinic acid, quercetin, apigenin, and carvacrol) have recently been shown to exert potent antioxidant activities in murine B16 melanoma cells, human HepG2 cells, human Caco-2 cells, and mice [ 23 , 32 , 35 , 36 ]. Furthermore, based on the fact that rosmarinic acid acts as a potent free radical scavenger and suppresses gene expression, and production of pro-inflammatory mediators, Adomako-Bonsu and colleagues [ 32 ] have proposed that the potential protective and therapeutic benefits of rosmarinic acid or other phenolics on topical diseases/disorders were likely the result of the combined effects of anti-inflammatory and antioxidant properties.…”

Section: Resultsmentioning

confidence: 94%

Ethanolic Extract of Origanum vulgare Suppresses Propionibacterium acnes-Induced Inflammatory Responses in Human Monocyte and Mouse Ear Edema Models

et al. 2018

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Acne vulgaris (acne) is a common inflammatory skin disorder, and Propionibacterium acnes plays a major role in the development and progression of acne inflammation. Herbs possessing antimicrobial and anti-inflammatory activity have been applied as a medical option for centuries. In this study, we examined the suppressive effect of ethanolic oregano (Origanum vulgare) extract on live P. acnes-induced in vivo and in vitro inflammation. Following ethanol extraction of oregano leaves, four compounds with strong antioxidant activity, including rosmarinic acid, quercetin, apigenin, and carvacrol, were identified by high-performance liquid chromatography. Using the mouse ear edema model, we demonstrated that ethanol oregano extracts (EOE) significantly suppressed P. acnes-induced skin inflammation, as measured by ear thickness (32%) and biopsy weight (37%). In a separate study, using the co-culture of P. acnes and human THP-1 monocytes, EOE reduced the production of interleukin (IL)-8, IL-1β and tumor necrosis factor (TNF)-α up to 40%, 37%, and 18%, respectively, as well as the expression of these three pro-inflammatory mediators at the transcriptional level. Furthermore, EOE inhibited the translocation of nuclear factor-kappa B (NF-κB) into the nucleus possibly by inactivating toll-like receptor-2 (TLR2). The suppressive effect of EOE on live P. acnes-induced inflammatory responses could be due, in part, to the anti-inflammatory and antioxidant properties, but not the anti-microbial effect of EOE.

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Section: Resultsmentioning

confidence: 94%

Ethanolic Extract of Origanum vulgare Suppresses Propionibacterium acnes-Induced Inflammatory Responses in Human Monocyte and Mouse Ear Edema Models

et al. 2018

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“…Regarding its antioxidant effects, it was verified that apigenin down regulates adhesion molecules (Liu et al, 2011), while suppressing oxidative stress through its direct free radical scavenging action and upregulating intracellular antioxidant defences. Although displaying high antioxidant activity in vitro, assessed via different methods, the low intestinal absorption of apigenin verified in a Caco-2 cell monolayers model, indicates that encapsulation may be mandatory to enhance its bioavailability for applications as oral antioxidant drug/supplement (Pérez-Sánchez et al, 2017).…”

Section: Evaluation Of Bioactive Propertiesmentioning

confidence: 99%

Chemical composition and biological activities of Juçara (Euterpe edulis Martius) fruit by-products, a promising underexploited source of high-added value compounds

Garcia

Corrêa

Barros

et al. 2019

Journal of Functional Foods

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A B S T R A C TThe pulp of the fruits of Juçara (Euterpes edulis Martius), a native tree of the Atlantic Rainforest of Brazil, is widely consumed thanks to its flavour and nutritional value. The industrial production of Juçara fruit pulp generates solid residues (peel) which are usually discarded. In this work, a hydroalcoholic extract from Juçara peel flour was evaluated for its phenolic profile as well as for its bioactivities. A total of nineteen phenolic compounds were identified in the Juçara peel flour. Among these, seventeen were non-anthocyanin phenolic compounds, namely two phenolic acids, four flavanonols, six flavones, and five flavonols; whereas the two anthocyanin molecules were cyanidin glycoside derivatives. The Euterpe edulis peel flour presented antioxidant activity and antibacterial potential but was not hepatotoxic. These observations corroborate the idea that this byproduct could fit well into the circular bioeconomy concept, thus promoting the Juçara fruit production chain.

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Effect of different extracts and fractions of Senecio biafrae (Oliv. &Hiern) J. Moore on in vivo and in vitro parameters of folliculogenesis in experimental animals

Lienou

Telefo

Rodrigues

et al. 2020

Journal of Ethnopharmacology

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Antioxidant activity and intestinal absorption of apigenin and its potassium salt derivative in Caco-2 cell monolayers

Cited by 3 publications

References 0 publications

Ethanolic Extract of Origanum vulgare Suppresses Propionibacterium acnes-Induced Inflammatory Responses in Human Monocyte and Mouse Ear Edema Models

Ethanolic Extract of Origanum vulgare Suppresses Propionibacterium acnes-Induced Inflammatory Responses in Human Monocyte and Mouse Ear Edema Models

Chemical composition and biological activities of Juçara (Euterpe edulis Martius) fruit by-products, a promising underexploited source of high-added value compounds

Effect of different extracts and fractions of Senecio biafrae (Oliv. &Hiern) J. Moore on in vivo and in vitro parameters of folliculogenesis in experimental animals

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