Antioxidant Activity and Phenolics Analysis by HPLC-DAD of Solanum thomasiifolium Sendtner (Solanaceae)

Magalhães, Fernanda S.; Cassiano, Dayse Santos Almeida; Branco, Carla Rodrigues Cardoso; Silva, Tânia R. S.; Lins, Antonio C. S.; Silva, Tania M. S.; Branco, Alexsandro

doi:10.5530/fra.2014.1.4

Cited by 5 publications

(1 citation statement)

References 28 publications

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“…8 From aerial parts and leaves were isolated steroidal saponins. [9][10][11] As part of our chemical and pharmacological studies of Brazilian Solanum, [12][13][14][15][16][17][18][19][20][21][22][23][24] we report the chemical investigation on S. paniculatum. The present study with S. paniculatum roots resulted in the characterization of 17 3-aminofurostane alkaloids by ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC-TOF-MS/MS).…”

Section: Introductionmentioning

confidence: 99%

3-Aminofurostane Alkaloids from Solanum paniculatum (“Jurubeba Verdadeira”) Roots

Silva

Agra

et al. 2020

J. Braz. Chem. Soc.

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The roots of Solanum paniculatum (Solanaceae) have extensively been used in folk medicine to treat liver infections and as a diuretic. Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS) were used for the profiling and structural characterization of alkaloids from the roots of S. paniculatum. Sixteen 3-aminofurostane alkaloids were characterized as novel compounds. In this study, three principal alkaloids were isolated in mixture, and their structures were established by different spectroscopic methods, including 1D, 2D nuclear magnetic resonance (NMR) experiments, and the high-resolution electrospray ionization (HR-ESI)-MS analysis. The isolated alkaloids were used to explore fragmentation pathways. Compound identification was based on the exact mass and fragmentation behaviors. Two compounds were identified as new natural compounds as: (25R)-3β-amino-furost-5-en-22α,26-diol O(26)-β-D-glucopyranoside (fatimagraine) and (25R)-3β-amino-furost-22-en,26-ol O(26)-β-D-glucopyranoside (bhattacharyyaine). The unambiguous assignments of 1 H and 13 C NMR data and chemical correction of the structure alkaloid jurubine are reported for the first time.

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