Antioxidant activity and protective effect of extract of Celosia cristata L. flower on tert-butyl hydroperoxide-induced oxidative hepatotoxicity

Djulis (Chenopodiun formosaneum) and its bioactive compounds protect against oxidative stress in human HepG2 cells

“…ROS may also affect transcription factor binding DNA in several ways, including the activation of kinases, signalling cascades, the modulation of phosphatase activity, the control of synthesis and the degradation of transcription factors (Finley et al, 2011). Many studies have shown that t-BHP, an oxidative stressor, can be metabolized into free radical intermediates by cytochrome P450 and can induce acute oxidative stress, affect the cell integrity, result in loss of cell function, and ultimately cause apoptosis and necrosis (Kim et al, 2015). This study shows that treatment of t-BHP-induced cells with WECF results in a significant reduction in cytotoxicity caused by 0.2M t-BHP and that WECF decreases the t-BHP-induced ROS production in HepG2 cells.…”

The morphological and phytochemical studies on the effect of acute and recurrent irradiation in Celosia cristata seeds

“…Celosia cristata L., called "Jengger ayam" in Indonesia, is an ornament and herbaceous plants of the family Amaranthaceae, widely grown in Asia and Africa (Kim et al 2015b;Sun et al 2015). C. cristata has a unique shape and attractive colors of flowers.…”

“…Thus, this plant is also popular as the ornamental plant for landscape, potted, and cut flowers. C. cristata is also used as a medicinal plant with several biological activities such as antioxidant activity from flower extract (Kim et al 2015b), antiviral activity from leaves extract (Balasubrahmanyam et al 2000), immunomodulatory activity from polysaccharide CP1-1 isolated (Sun et al 2015), and hepatoprotective activity from saponin and triterpenoid saponin isolated ( Wang et al 2010;Sun et al 2011). Therefore, the diversity of morphology and metabolite in C. cristata needs to be increased to maximize the potential plants used as an ornamental and herb plant.…”

Evaluation of the Cellular and Animal Models for the Study of Antioxidant Activity: A Review

“…t ‐BHP has also been used extensively to induce oxidative stress in animals. After pretreatment with antioxidant extract for 2 wk or several days, Sprague‐Dawley rats were injected with different concentrations (2 mM/kg body weight, 0.2 mmol/kg body weight, or 0.5 mmol/kg body weight) of t ‐BHP intraperitoneally and were sacrificed for 8 or 18 h later (Wang and others ; Yang and others ; Kim and others ).…”