Antioxidant activity and α-glucosidase inhibition by essential oils from Hertia cheirifolia (L.)

Majouli, Kaouther; Hlila, Malek Besbes; Hamdi, Abdelaziz; Flamini, Guido; Jannet, Hichem Ben; Kénani, Abderraouf

doi:10.1016/j.indcrop.2015.12.015

Cited by 51 publications

(37 citation statements)

References 31 publications

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“…Similarly to previous activities, in the case of α ‐amylase and α ‐glucosidase, essential oils are inexhaustible sources of potential natural inhibitors. For example, Majouli et al . investigated Hertia cheirifolia L. towards providing potential inhibitors of the enzymes.…”

Section: Inhibitory Activity Of Common Terpenoidsmentioning

confidence: 99%

Natural Monoterpenes: Much More than Only a Scent

Wojtunik-Kulesza

Kasprzak

Oniszczuk

et al. 2019

Chemistry & Biodiversity

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Terpenes are a widespread group of secondary metabolites that can be found in various family plants such as the Lamiaceae. In view of their numerous valuable biological activities, the industrial production of concrete terpenes and essential oils rich in the substances is intensively studied. Monoterpenes constitute a significant part of the whole group of the aforementioned secondary metabolites. This is due to their numerous biological activities and their ability to permeate the skin. Despite the fact that these substances have gain popularity, they are not comprehensively characterized. The presented review is based on studies of the biological activities of the most important monoterpenes and the essential oils rich in these compounds. The authors focused attention on antioxidant activity, inhibition towards acetyl-and butyrylcholinesterase, and α-amylase and α-glucosidase, antifungal, hepatoprotective, sedative properties, and their skin permeation enhancement.

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Section: Inhibitory Activity Of Common Terpenoidsmentioning

confidence: 99%

Natural Monoterpenes: Much More than Only a Scent

Wojtunik-Kulesza

Kasprzak

Oniszczuk

et al. 2019

Chemistry & Biodiversity

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“…α-Glucosidase is a key enzyme in the hydrolysis of oligosaccharide and contributes to the formation of glucose. 38 It is important to find a new α-glucosidase inhibitor for DM, such as natural products with low toxicity and adverse effects.…”

Section: Discussionmentioning

confidence: 99%

The in vitro protection by Crataegus microphylla extracts against oxidative damage and enzyme inhibition effects

Renda¹,

Özel²,

Barut³

et al. 2018

tjps

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Crataegus türleri gıda olarak ve halk arasında çeşitli hastalıkların tedavisinde kullanılmaktadır. Bu çalışma Türkiye'den toplanan Crataegus microphylla C. Koch'tan hazırlanan farklı ekstraktların biyolojik özelliklerini araştırmayı amaçlamaktadır. Gereç ve Yöntemler: Kurutulmuş yaprak, gövde kabuğu ve taze meyve örnekleri ayrıldı ve etanol ekstresi, asitlendirilmiş (%0.5 HCl, pH: 2.5) etanol ekstresi, etanol:su (1:1) ekstresi, metanol ekstresi, asitlendirilmiş (%0.5 HCI, pH: 2.5) metanol ekstresi, metanol:su (1:1) ekstresi, su ekstresi ve asitlendirilmiş (%0.5 HCI, pH: 2.5) su ekstresi hazırlandı. Ekstrelerin oksidatif DNA hasarının önlenmesi, asetilkolinesteraz, tirozinaz, α-glukozidaz inhibisyonu ve antioksidan aktivitesi 2,2-difenil-1-pikrilhidrazil (DPPH) radikal süpürme, PRAP ve FRAP gibi çeşitli biyolojik aktiviteleri farklı konsantrasyonlarda araştırılmıştır. Bulgular: Gövde kabuklarından asitlendirilmiş metanol ekstraktı sırasıyla 204.02±0.95 μg/mL ve 37.30±0.27 μg/mL IC 50 değerleri ile diğer esktreler arasında en yüksek asetilkolinesteraz ve tirozinaz inhibisyonu göstermiştir. Yaprakların asitlendirilmiş etanol ekstresi, α-glukosidaz enzimine karşı 15.78±0.14 μg/mL ile en düşük IC 50 değerini göstermiştir. DPPH için asitleştirilmiş etanol ekstraktının IC 50 değeri 9.89±0.09 ug/mL bulunmuştur. 125 μg/mL dozunda yaprakların ve gövde kabuklarının metanol ekstreleri, süpersarmal pBR322 DNA üzerinde hidroksil iyonu (. OH) tarafından DNA sarmalının kesilmesine karşı önemli koruma aktivitesi sergiledi. Sonuç: C. microphylla gövde kabuğu ve yaprak ile hazırlanan asitlendirilmiş metanol veya etanol ekstrelerinin potansiyel antioksidan, hipoglisemik ve nöroprotektif etkileri bulunmaktadır.

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“…The K i values derived from secondary plots ( Figure 2b, 2d, 2f, and 2h) for corilagin, geraniin, ellagic acids, and myricetrin were 0.037, 0.029, 0.017, and 0.020 mM, respectively. A smaller value of inhibition constant indicated stronger inhibition and the inhibitor-enzyme binding affinity exceeded the enzyme-substrate binding affinity [33].…”

Section: Kinetics Studiesmentioning

confidence: 99%

Xanthine Oxidase Inhibitors Screening, Antioxidation, and DNA Protection Properties of Geranium wilfordii Maxim

Liu

Mei

Xiao

et al. 2019

eFood

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KeywordsAntioxidation DNA damage DPPH spiking inhibitor ultrafiltration xanthine oxidase A B S T R A C TGeranium wilfordii Maxim is a commonly used traditional medicine and as decoction pieces in drinks for treating acute and chronic rheumatalgia. Earlier research showed it could inhibit xanthine oxidase and had a strong antioxidative activity. In this study, four compounds namely, corilagin, geraniin, ellagic acid, and myricetrin were screened and identified as xanthine oxidase inhibitors and antioxidants using ultrafiltration combined liquid chromatography-mass spectrometry (LC-MS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) spiking combined LC-MS methods. Ellagic acid showed the greatest inhibition with IC 50 of 0.018 ± 0.001 mM better than that of allopurinol. The kinetic parameters exhibited the mode of xanthine oxidase inhibitions by corilagin, geraniin, and myricetrin were the competitive types, whereas the ellagic acid was found as an uncompetitive inhibitor. In vitro DNA nicking assay showed these four compounds protected DNA from reactive oxygen species. Correlation analysis and partial least squares analysis showed there was a moderate correlation between ellagic acid and DPPH˙ scavenging activity. Our findings revealed four compounds in G. wilfordii Maxim contributed satisfied radicals scavenging, xanthine oxidase inhibition, and DNA damage protective activities. More comprehensive research on pharmaceutical applications and phytochemical profile of G. wilfordii Maxim could be further studied.

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Antioxidant activity and α-glucosidase inhibition by essential oils from Hertia cheirifolia (L.)

Cited by 51 publications

References 31 publications

Natural Monoterpenes: Much More than Only a Scent

Natural Monoterpenes: Much More than Only a Scent

The in vitro protection by Crataegus microphylla extracts against oxidative damage and enzyme inhibition effects

Xanthine Oxidase Inhibitors Screening, Antioxidation, and DNA Protection Properties of Geranium wilfordii Maxim

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