Antioxidant Activity Evaluation in a Series of Heterocyclic Compounds Derived from 1,8-Diaminonaphthalene

Tiéba, Tuo Nanou; Baptiste, Kangah Niameke Jean; Daouda, Ballo; Claude, Kablan Ahmont Landry; Guillaume, Kodjo Charles; Bernard, Yapo Ossey; Ziao, Nahossé

doi:10.4236/jbpc.2021.121001

Cited by 3 publications

(2 citation statements)

References 17 publications

(16 reference statements)

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“…Incubated the sample for one hour at 37°C. The basic of this assay is that the DPPH radical can be reduced to form stable molecular in presence of a substance that can donate an electron or hydrogen atom to it, and as a result the purple color of free radical converted to yellow, which can be measured in the visible spectrum to give a strong absorption at 517 nm [22].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Synthesis, Characterization, Molecular docking, Antibacterial Activity, Antioxidant and Anticancer of New 1,2,4-Triazole Derivative

Saadi,

Adnan

2024

J. K. Chem. Sci.

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A novel 1,2,4-triazole-5-thiol derivative was designed through a series of reactions. Firstly, Azo derivative 1 was synthesized by a general method with two steps, a diazotization reaction in an acidic medium, and a coupling reaction in basic conditions. Secondly, Azo-carboxylic acid 1 reacted with SOCl2 to produce acid chloride derivative 2. Then carbothiamide derivative 3 was synthesized through substitution reaction by reacting 2 with 4-phenyl thiosemicarbazide in pyridine. In the next step, carbothiamide 3 was reacted with sodium hydroxide solution to afford target triazole derivative 4. The structures of all synthesized derivatives were confirmed by techniques (1H, 13C NMR, IR). Moreover, the triazole derivative 4 was evaluated for its biological activity as an anticancer, antioxidant, and antibacterial. The results presented that compound 4 has moderate antibacterial activity and a high free radical scavenging effect (IC50 30.2 μg/mL) compared to vitamin C (IC50 21 μg/mL). The anticancer activity results presented that compound 4 has a toxic effect on a colon cancer cell line CaCo-2. The potential effect of compound 4 on the 5lqf protein was examined in silico studies.

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Section: Antioxidant Activitymentioning

confidence: 99%

Synthesis, Characterization, Molecular docking, Antibacterial Activity, Antioxidant and Anticancer of New 1,2,4-Triazole Derivative

Saadi,

Adnan

2024

J. K. Chem. Sci.

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“…The antioxidant activity of the prepared oxazolone derivative containing the hydroxyl group was evaluated using the rapid method (DPPH radical scavenging) in which the DPPH radical is characterized by its strong absorption and at a wavelength of 517 nm [29][30][31], which changes color in the presence of an oxidizing substance from violet to yellow. Methanol-DMSO mixture was used as the sample solvent.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Synthesis, Antibacterial and Antioxidant Evaluation of 2-Substituted-4-arylidene-5(4<i>H</i>)-oxazolone Derivatives

Saadi,

Adnan

2023

Indones. J. Chem.

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In this research, the synthesis of new substituted oxazolone derivatives is described via Erlenmeyer synthesis of N-acyl amino acid. Firstly, the azo derivative 1 was prepared by coupling the diazonium salt of 3-amino-4-methoxybenzoic acid with 4,5-dichloroimidazole in sodium hydroxide solution. Benzoyl chloride derivative 2, the key intermediate of the synthesis, was synthesized by the acylation of azo-carboxylic acid derivative 1 with thionyl chloride. The resulting acyl chloride derivative reacted with glycine in a basic catalyst to form a hippuric acid derivative 3. After that, oxazolone derivatives 4a–4f were prepared via the reaction of the hippuric acid derivative with various aromatic aldehydes. All new compound structures were confirmed by spectral techniques, i.e., FTIR, 1H-NMR, 13C-NMR spectroscopy, and elemental analysis. The antimicrobial activity (Staphylococcus aureus and Escherichia coli) of all new compounds was screened in vitro. The results against S. aureus and E. coli showed that most of the tested compounds have an activity ranging from moderate to low. The antioxidant activity of derivative 4a was also evaluated and showed good antioxidant activity.

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Design and Synthesis of Neoteric Benzylidene Amino-Benzimidazole Scaffolds for Antioxidant and Anti-Inflammatory Activity

Swikriti

Babbar

Saini³

et al. 2023

Future Med. Chem.

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Aim: To design a series of neoteric benzylidene amino-benzimidazole derivatives and to synthesize and evaluate them for anti-inflammatory and antioxidant potential. Methods: The designed target scaffolds were synthesized and appraised for in vitro antioxidant action and in vivo anti-inflammatory potential. AutoDock Vina software was employed for design; the Mannich reaction was used for synthesis; and antioxidant and anti-inflammatory potential were demonstrated by the 2,2-diphenyl-1-picryl hydrazyl free-radical scavenging assay and carrageenan-induced paw edema method, respectively. Results: Methyl-incorporating molecules 3-(2-((2-methylbenzylidene)amino)-1H-benzo[d]imidazol-1-yl)-1-phenylpropan-1-one (6c) and 3-(2-((4-methylbenzylidene)amino-1H-benzo[d]imidazol-1-yl)-1-phenylpropan-1-one (6j) showed remarkable antioxidant and anti-inflammatory action, followed by compounds 6f, 6e and 6i containing 3-CH3, 2-OH, 4-F substituents, respectively. Conclusion: The designed analogs were dynamically confined within the active site of cyclooxygenase-2, and in vitro and in vivo results agreed with molecular docking studies.

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Antioxidant Activity Evaluation in a Series of Heterocyclic Compounds Derived from 1,8-Diaminonaphthalene

Cited by 3 publications

References 17 publications

Synthesis, Characterization, Molecular docking, Antibacterial Activity, Antioxidant and Anticancer of New 1,2,4-Triazole Derivative

Synthesis, Characterization, Molecular docking, Antibacterial Activity, Antioxidant and Anticancer of New 1,2,4-Triazole Derivative

Synthesis, Antibacterial and Antioxidant Evaluation of 2-Substituted-4-arylidene-5(4<i>H</i>)-oxazolone Derivatives

Design and Synthesis of Neoteric Benzylidene Amino-Benzimidazole Scaffolds for Antioxidant and Anti-Inflammatory Activity

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