Antioxidant Activity of a Dihydroquercetin Isolated fromLarix gmelinii (Rupr.) Rupr. Wood

Kolhir, V. K.; Быков, В. А.; Baginskaja, A. I.; Sokolov, S. Ya.; Glazova, N. G.; Leskova, T. E.; Sakovich, G. S.; Tjukavkina, N. A.; Kolesnik, Yu. A.; Rulenko, I. A.

doi:10.1002/(sici)1099-1573(199609)10:6<478::aid-ptr883>3.0.co;2-s

Cited by 35 publications

(6 citation statements)

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“…Such compound also occur naturally in several plants, including Douglas-Fir heartwood [22], Manduca butyraceae [23], Drimys winteri [24], etc. Besides its analgesic and anti-inflammatory effects, compound 2 also exhibited antifungal [25], antiviral [26] and antioxidant [27] properties. Although the flavonoids represent an important class of naturally occurring substances with different biological actions [28−30], to our best knowledge this is the first demonstration of the pharmacological actions of the flavonoids reported here, except for taxifolin (2).…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive and Anti-oedematogenic Properties of Astilbin, Taxifolin and Some Related Compounds

Cechinel‐Filho

Vaz

Zunino

et al. 2011

Arzneimittelforschung

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Astilbin (3-0-alpha-1-rhamnosyl-(2R,3R)-dihydroquercetin), the major constituent isolated from Hymeneae martiana and some derivatives obtained by structural modification, such as taxifolin and two related compounds, were evaluated as analgesics by using both writhing test and formalin test in mice. Their anti-oedematogenic actions were also analysed against paw oedema caused by carrageenan, dextran and bradykinin in rat. The results indicated that some compounds, such as taxifolin (2) and its tetramethylated derivative (4) exhibited potent and dose-dependent antinociceptive action against acetic acid-induced abdominal constriction when administered intraperitoneally or orally. They were more potent than acetylsalicylic acid and paracetamol (acetaminophen), two standard drugs used for comparison. Compounds 2 and 4 were also more potent than these drugs in attenuating to the second phase of the formalin-induced licking. Moreover, both compounds showed significant anti-oedematogenic effect, inhibiting the paw oedema formation induced by dextran. In contrast pentaacetylated taxifolin (3) was capable of inhibiting the paw oedema induced by bradykinin.

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Section: Discussionmentioning

confidence: 99%

Antinociceptive and Anti-oedematogenic Properties of Astilbin, Taxifolin and Some Related Compounds

Cechinel‐Filho

Vaz

Zunino

et al. 2011

Arzneimittelforschung

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“…The structures in Figure 1a,b are diastereomers for molecules in Figure 1c,d. Safety and efficacy have been confirmed for Diquertin ® -a remedy on the taxifolin basis [32]. According to X-ray crystallography and circular dichroism data, the reference sample obtained from Diquertin ® is a 2R,3R-configuration of taxifolin, which corresponds to the structure of the trans-diastereomer [33].…”

Section: Introductionmentioning

confidence: 94%

Diastereomers of Spheroidal Form and Commercially Available Taxifolin Samples

Terekhov,

Melnikov,

Nikitin

et al. 2024

Sci. Pharm.

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Taxifolin is a natural polyphenol belonging to the class of flavonoids. The structure of this compound is characterized by the presence of two chiral centers. The spheroidal form of taxifolin (TAXs) has emerged as a promising modification due to enhanced solubility, higher safety profile, and long-term release from solid dosage forms. The study’s objective was to assess the diastereomeric content in TAXs and industrially produced samples of taxifolin. Considering the difference in the physico-chemical properties of diastereomers and based on the literature data, we developed a qualitative HPLC method. The chromatograms were recorded using a diode array detector at 290 nm and a mass spectrometer operated in negative ionization mode. Our data suggest that a biphenyl column and gradient elution using 0.1% formic acid in water and 0.2% formic acid in methanol, with the organic phase gradient from 7% to 21% and a flow rate of 0.65 mL/min for 15 min at 60 °C, provides the best conditions for the separation of taxifolin diastereomers. This method was validated for quantitative analysis. We discovered that the cis-isomer was present in all the analyzed samples, with its quantity ranging from 0.8% to 9.5%. TAXs can be considered a sample enriched with diastereomers.

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“…This is why taxifolin can be used for minimizing or preventing lipid oxidation in food or pharmaceutical products which results in maintaining product nutritional quality and prolonging shelf life [ 95 ]. Taxifolin antioxidant activity is associated with blood capillary protection [ 96 ] and it is also exhibited through its neuroprotective effects via the inhibition of oxidative neuronal injuries in rat cortical cells [ 97 ].…”

Section: Flavonoidsmentioning

confidence: 99%

Secondary Metabolites with Biomedical Applications from Plants of the Sarraceniaceae Family

Miclea

2022

IJMS

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Carnivorous plants have fascinated researchers and hobbyists for centuries because of their mode of nutrition which is unlike that of other plants. They are able to produce bioactive compounds used to attract, capture and digest prey but also as a defense mechanism against microorganisms and free radicals. The main purpose of this review is to provide an overview of the secondary metabolites with significant biological activity found in the Sarraceniaceae family. The review also underlines the necessity of future studies for the biochemical characterization of the less investigated species. Darlingtonia, Heliamphora and Sarracenia plants are rich in compounds with potential pharmaceutical and medical uses. These belong to several classes such as flavonoids, with flavonol glycosides being the most abundant, monoterpenes, triterpenes, sesquiterpenes, fatty acids, alkaloids and others. Some of them are well characterized in terms of chemical properties and biological activity and have widespread commercial applications. The review also discusses biological activity of whole extracts and commercially available products derived from Sarraceniaceae plants. In conclusion, this review underscores that Sarraceniaceae species contain numerous substances with the potential to advance health. Future perspectives should focus on the discovery of new molecules and increasing the production of known compounds using biotechnological methods.

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Antioxidant Activity of a Dihydroquercetin Isolated fromLarix gmelinii (Rupr.) Rupr. Wood

Cited by 35 publications

References 0 publications

Antinociceptive and Anti-oedematogenic Properties of Astilbin, Taxifolin and Some Related Compounds

Antinociceptive and Anti-oedematogenic Properties of Astilbin, Taxifolin and Some Related Compounds

Diastereomers of Spheroidal Form and Commercially Available Taxifolin Samples

Secondary Metabolites with Biomedical Applications from Plants of the Sarraceniaceae Family

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