Antioxidant Activity of All-trans-retinol in Homogeneous Solution and in Phosphatidylcholine Liposomes

Tesoriere, Luisa; Ciaccio, Marcello; Bongiorno, A; Riccio, Antonio; Pintaudi, Anna Maria; Livrea, Maria Antonia

doi:10.1006/abbi.1993.1581

Cited by 83 publications

(48 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, in general the peroxyl radical scavenging ability of a carotenoid is proportional to the length of the conjugated double bond section of the compound (Sies and Stahl, 1995). The antioxidant activities of Vitamin A compounds are also thought to arise from their ability to stabilise peroxyl radicals and perhaps even the potentially damaging glutathione radical (Tesoriere et al, 1993;D'Aquino et al, 1989). Using an in vitro peroxidation system, antioxidant activities of retinoids have been ranked as retinol>=retinal»retinyl palmitate>retinoic acid (Das, 1989).…”

Section: Vitamin a And Early Developmentmentioning

confidence: 99%

Vitamins A and E in the maternal diet influence egg quality and early life stage development in fish: a review

Palace¹,

Werner²

2006

Sci. Mar.

View full text Add to dashboard Cite

SUMMARY: Early development in fish is dependent on essential nutrients present in the egg. Vitamins E and A are critical to the normal development of fish embryos. Vitamin E functions primarily as an antioxidant to protect unsaturated lipids from oxidative degradation. Vitamin A or its provitamin carotenoid forms support growth, are required for the differentiation and maintenance of epithelial tissue and can be converted to forms of the vitamin that are potent morphogens. Fish cannot synthesise either of the vitamins, so the maternal dietary content of each prior to oogenesis is an important determinant of reproductive fitness. Here we review the basic metabolism of vitamins E and A and carotenoids and their processing from the maternal diet and deposition into eggs. Evidence for the link between levels of each of the vitamins in eggs and measures of reproductive fitness are also discussed. -El desarrollo embrionario en peces es dependiente de los nutrientes esenciales presentes en el huevo. Las vitaminas E y A son críticas en el desarrollo normal de los embriones de los peces. La vitamina E funciona sobre todo como un antioxidante para proteger los lípidos no saturados contra la degradación oxidativa. La vitamina A, o los carotenoides formas de provitamina, se requieren para la diferenciación y el mantenimiento del tejido fino epitelial y se puede convertir a las formas de la vitamina que son morfogenes potentes. Los peces tampoco pueden sintetizar las vitaminas, de modo que el contenido dietético materno de cada una antes de la oogenesis es un determinante importante de la aptitud reproductiva. Aquí repasamos el metabolismo básico de las vitaminas E y A y los carotenoides y su procesamiento desde la dieta materna a la deposición en los huevos. Se discute también la evidencia del acoplamiento entre los niveles de cada una de las vitaminas en los huevos y las medidas de aptitud reproductiva en los adultos.

show abstract

Section: Vitamin a And Early Developmentmentioning

confidence: 99%

Vitamins A and E in the maternal diet influence egg quality and early life stage development in fish: a review

Palace¹,

Werner²

2006

Sci. Mar.

View full text Add to dashboard Cite

show abstract

“…In fact, it may be even more effective than tocopherol, by virtue of its shorter polyene chain that affords it increased mobility and better access to peroxyl radicals in the membrane. 35 However, the ability of retinol to scavenge aqueous initiator species is far below that of tocopherol owing to the fact that it lacks a hydroxyl group at the membrane surface. 35 Rats supplemented with vitamin E still had lower vitamin A in the liver after MI, which suggests that this organ may experience different stresses on its vitamin A pool and its handling capabilities after MI.…”

Section: Vitamin a Changesmentioning

confidence: 99%

Mobilization of Antioxidant Vitamin Pools and Hemodynamic Function After Myocardial Infarction

et al. 1999

View full text Add to dashboard Cite

Background-Although most previous studies have attempted to correlate plasma concentrations of vitamins with specific cardiovascular end points, metabolic considerations suggest that changes in myocardial tissue and storage organs may be better indicators of myocardial oxidative stress. Methods and Results-Rats fed commercial chow or a diet enriched with vitamin E for 2 weeks were subjected to either a surgical myocardial infarction (MI) or a sham procedure. Rats were hemodynamically assessed 16 weeks after surgery, and their heart, liver, kidney, and plasma were analyzed for antioxidant vitamins E (tocopherol) and A (retinol and total retinyl esters). At 16 weeks, MI rats on a control diet showed depressed peak systolic and elevated diastolic pressures in both right and left ventricles compared with their sham controls. Plasma concentrations of vitamins E and A in MI rats were not different from sham controls fed the same diet. However, concentrations of vitamin E in left ventricle and liver and of vitamin A in liver (retinol) and kidney (retinyl esters) were decreased in rats with MI compared with the sham controls. Vitamin E supplementation improved hemodynamic function in rats with MI and increased plasma, myocardial, liver, and kidney concentrations of vitamin E. The vitamin E diet also prevented the loss of total retinyl esters from the kidney but not of retinol from the liver in MI rats. Conclusions-Dietary

show abstract

“…Retinol is about 3 times less effective than tocopherol as an antioxidant [35]. However, retinol has an additive effect for conferring resistance to lipid peroxidation [36]when it is added to tocopherol.…”

Section: Discussionmentioning

confidence: 99%

Lipophilic Antioxidants and Iron Status in ESRD Patients on Hemodialysis

Lim

Chan

et al. 2000

Nephron

View full text Add to dashboard Cite

Cardiovascular disease remains the major cause of mortality in hemodialysis patients. Abnormal oxidative stress and impaired antioxidant defense may contribute to accelerated atherogenesis associated with uremia. As oxidative modification of lipids appears to be a prerequisite for the development of atherosclerotic lesions, lipophilic antioxidants may be protective. The aim of this study was to determine the plasma levels of lipophilic antioxidants in 82 hemodialysis patients and 30 controls and to investigate the influence of body iron status on the levels of lipophilic antioxidants. The patients were categorized into 3 groups according to their serum ferritin levels. We found that the plasma levels of lycophene, δ-tocopherol, γ-tocopherol and retinol of hemodialysis patients were lower than those of controls. On the other hand, both absolute and lipid-normalized plasma lycophene levels were significantly reduced in those patients in the groups with higher ferritin levels as compared to those with lower ferritin levels. In addition, our study showed that the lipid-normalized plasma levels of β-carotene and α-carotene of hemodialysis patients with higher ferritin levels were lower than those of the patients with lower levels. These data suggest that the plasma levels of lipophilic antioxidants are altered in end-stage renal disease on hemodialysis and may be considered as markers of oxidative stress in these patients. Most importantly, elevated serum ferritin levels may affect the levels of these lipophilic antioxidants.

show abstract

Antioxidant Activity of All-trans-retinol in Homogeneous Solution and in Phosphatidylcholine Liposomes

Cited by 83 publications

References 0 publications

Vitamins A and E in the maternal diet influence egg quality and early life stage development in fish: a review

Vitamins A and E in the maternal diet influence egg quality and early life stage development in fish: a review

Mobilization of Antioxidant Vitamin Pools and Hemodynamic Function After Myocardial Infarction

Lipophilic Antioxidants and Iron Status in ESRD Patients on Hemodialysis

Contact Info

Product

Resources

About