Antioxidant activity of Annona crassiflora: Characterization of major components by electrospray ionization mass spectrometry

Roesler, Roberta; Catharino, Rodrigo Ramos; Malta, Luciana Gomes; Eberlin, Marcos N.; Pastore, Gláucia Maria

doi:10.1016/j.foodchem.2007.01.017

Cited by 104 publications

(80 citation statements)

References 26 publications

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“…Lipid peroxidation may be prevented at the initiation stage by free radical scavengers, whereas the chain propagation reaction can be intercepted by peroxy-radical scavengers such as phenolic antioxidants (TAKAHAMA, 1983). The investigation by direct infusion electrospray ionization mass spectrometry (ESI-MS) provided important information of biactive components of araticum extracts mainly phenolic antioxidants such as caffeic acid, quinic acid, ferulic acid, xanthoxylin, caffeoyltartaric acid, caffeoyl glucose, [quercetin + hexose + pentose -H]-, and rutin (ROESLER et al, 2007).The phenolic compounds act by scavenging free radicals and quenching the lipid peroxides. The hydroxyl and phenoxy groups of phenolic compounds donate their electron to the free radicals and neutralize them forming phenolic radical and quinine methide intermediate, which is excreted via bile (PAN et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Briefly, toxicity or other organ damage. However, rats that received the seed extract showed some anxiety and were restless, perhaps because of the phenolic acids and their derivatives (caffeic acid, caffeoyl glucose, and caffeoyl tartaric) present in this extract (ROESLER et al, 2007). There were significant differences among the body weight gain of the groups that received seed extract (G4 and G6) compared with the control group (G1).…”

Section: Determination Of the Total Phenol Contentmentioning

confidence: 99%

“…In previous studies, the seeds and peel of slightly ripe fruit were found to have significant antioxidant activity in various models in vitro (ROESLER et al, 2006). Electrospray ionization mass spectrometry (ESI-MS) also revealed the presence of important bioactive components widely recognized as antioxidants including malic acid, ascorbic acid, caffeic acid, quinic acid, ferulic acid, xanthoxylin, rutin, caffeoyltartaric acid, caffeoyl glucose, and [quercetin + hexose + pentose -H]-1 (ROESLER et al, 2007). The aim of the present study was to assess the protective effect of an ethanolic extract of A. crassiflora seeds and peel in Wistar rats treated with carbon tetrachloride (CCl 4 ).…”

Section: Lipid Peroxidationmentioning

confidence: 99%

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Effect of extracts from araticum (Annona crassiflora) on CCl4-induced liver damage in rats

Roesler¹

2011

Ciênc. Tecnol. Aliment.

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Section: Discussionmentioning

confidence: 99%

Section: Determination Of the Total Phenol Contentmentioning

confidence: 99%

Section: Lipid Peroxidationmentioning

confidence: 99%

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Effect of extracts from araticum (Annona crassiflora) on CCl4-induced liver damage in rats

Roesler¹

2011

Ciênc. Tecnol. Aliment.

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“…In vitro and in vivo studies indicate that either pulp or ethanolic extracts of A. crassiflora Mart.o leaves did not present potential mutagenic or genotoxic effects, as evaluated using micronuclei, SOS-Inductest or Ames tests (DRAGANO et al, 2010;FERRI;CHEN-CHEN, 2011). Although A. crassiflora Mart.…”

Section: Introductionmentioning

confidence: 95%

“…The pulp of the A. crassiflora Mart. contains carotenoids, (DRAGANO et al, 2010;ROESLER et al, 2007). Given their selective effects, some of these compounds are potential anti-cancer agents against different human cancer cell lines in vitro (JASWIR et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Annona crassiflora Mart. fruit pulp effects on biochemical parameters and rat colon carcinogenesis

et al. 2013

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A. crassiflora Mart. a Brazilian savannah fruit, is a source of phytochemical compounds that possess a wide array of biological activities, including free radical scavenging. This native fruit proved to potentialize the mutagenic process in previous in vivo investigations. The aim of the present study was to investigate the effects of A. crassiflora Mart. pulp intake on colonic cell proliferation and on the development of Aberrant Crypt Foci (ACF) in male Wistar rats. The animals were fed with either a commercial diet or a diet supplemented with A. crassiflora Mart. pulp mixed in 1%, 10% or 20% (w/w) for 4 weeks or 20 weeks. The carcinogen 1,2-dimethylhydrazine dihydrochloride (4 doses, 40 mg kg -1 each) was used to induce colonic ACF. After euthanasia, the blood, liver and colon samples were collected for biochemical determinations, oxidative stress or ACF development analysis, respectively. Immunohistochemical analyses of the colonic mucosa were performed using antibodies against proliferating cell nuclear antigen (PCNA) in normal-appearing colonic crypt and β-catenin in ACF. There was no ACF development in the colon from groups treated with A. crassiflora Mart. pulp. Also, the biochemical and oxidative stress analysis, PCNA labeling and ACF development (number, multiplicity or cellular localization of β-catenin) were unchanged as a result of marolo pulp intake. Thus, the present results suggest that A. crassiflora Mart. pulp intake did not exert any protective effect in the colon carcinogenesis induced by DMH in rats.Index terms: Aberrant crypt foci, brazilian savannah, dimethylhydrazine, immunohistochemistry, oxidative stress. RESUMOO marolo (Annona crassiflora Mart.) é uma fruta do cerrado brasileiro e fonte de compostos fitoquímicos com grande variedade de atividades biológicas, incluindo eliminação de radicais livres. Entretanto, em estudos anteriores, essa fruta nativa mostrou-se como potencializadora do processo mutagênico in vivo. Objetivou-se, neste estudo, investigar os efeitos da ingestão da polpa de marolo sobre a proliferação de células do cólon e no desenvolvimento de lesões pré-neoplásicas por meio de focos de criptas aberrantes (ACF) em ratos Wistar. Os animais foram alimentados com dieta comercial ou suplementada com polpa de marolo nas proporções de 1%, 10% ou 20% (m/ m), durante 4 semanas, ou 20 semanas. Como agente indutor da carcinogênese de cólon foi utilizado o dicloridrato de 1,2-dimetilhidrazina (4 doses, 40 mg kg -1 cada). Após a eutanásia, as amostras de sangue, fígado e cólon foram coletadas para determinações bioquímicas, estresse oxidativo ou análise de desenvolvimento de Focos de Criptas Aberrantes (FCA), respectivamente. A análise imunohistoquímica da mucosa do cólon foi realizada, utilizando anticorpos contra o antígeno nuclear de proliferação celular (PCNA) e β-catenina em FCA. Não houve desenvolvimento de FCA no cólon nos grupos tratados exclusivamente com polpa de marolo. Além disso, a análise de estresse oxidativo e bioquímico, PCNA e de desenvolvimento (multiplicid...

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Chemical Characterization, Antioxidant and Cytotoxic Activities of the Edible Fruits of Brosimun gaudichaudii Trécul, a Native Plant of the Cerrado Biome

Engelbrecht

Ribeiro

Yoshida

et al. 2021

Chemistry & Biodiversity

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In Brazil, there is a large diversity of species of small edible fruits that are considered sources of nutrients and functional properties. They present a high innovation domain for the pharmaceutical, cosmetic and food industries due to their health-promoting properties. Edible fruits from Brosimum gaudichaudii (Moraceae) are widely consumed and used in folk medicine and in feed by the population of the Brazilian Cerrado. Nevertheless, detailed information on the chemical fingerprint, antiradical activity and safety aspects of these fruits is still unknown. Thus, the aim of this work was to investigate the bioactive compounds of hydroethanolic extracts of fruits from Brosimum gaudichaudii using high-performance liquid chromatography combined with mass spectrometry using electrospray ionization (HPLC ESI-MS). Eighteen different compounds, including flavonoids, coumarins, arylbenzofurans, terpenoids, stilbenes, xanthones and esters, were detected. Moreover, the study indicated that the hydroethanolic extract of fruits from B. gaudichaudii presented low scavenging activity against 2,2-diphenyl-1-picrylhydrazyl radicals (IC 50 > 800 μg mL À 1 ) and was cytotoxic (IC 50 < 30 μg mL À 1 ) in Chinese hamster ovary cells (CHOÀ K1) by an in vitro assay. This is the first report of the chemical profile, antioxidant activity and cytotoxic properties of the hydroethanolic extract of fruits from B. gaudichaudii.

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Antioxidant activity of Annona crassiflora: Characterization of major components by electrospray ionization mass spectrometry

Cited by 104 publications

References 26 publications

Effect of extracts from araticum (Annona crassiflora) on CCl4-induced liver damage in rats

Effect of extracts from araticum (Annona crassiflora) on CCl4-induced liver damage in rats

Annona crassiflora Mart. fruit pulp effects on biochemical parameters and rat colon carcinogenesis

Chemical Characterization, Antioxidant and Cytotoxic Activities of the Edible Fruits of Brosimun gaudichaudii Trécul, a Native Plant of the Cerrado Biome

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