The aim of the current study was to evaluate the cardioprotective ability of water (WE) and ethanolic (EE) papaya fruits extracts against cardiotoxicity induced by aflatoxin B 1 (AFB 1 ) in rats. Forty two female Sprague-Dawley rats were divided into six treatment groups and treated orally for 2 weeks as follow: control group, the group treated with WE (250 mg/kg b.w), the group treated with EE (250 mg/kg b.w), the group treated orally with AFB 1 (17 lg/kg b.w) and the groups treated orally with AFB 1 plus WE or EE. The results indicated that treatment with AFB 1 resulted in oxidative stress in the heart manifested by the marked increase in cardiac malondialdehyde and calcium levels accompanied with a significant decrease in cardiac total antioxidant capacity. Serum nitric oxide and sodium levels, lactate dehydrogenase and creatine kinase isoenzyme activities were significantly increased, whereas, cardiac Na ? /K ? -ATPase activity and serum potassium were insignificantly affected. Supplementation with WE or EE effectively ameliorated most of the changes induced by AFB 1 . It could be concluded that both extracts attenuated the oxidative stress induced in heart tissue by AFB 1 and WE was more pronounced due to the higher total phenolic contents than in the EE.