Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline

Gülçın, İlhami; Élias, Riad; Gepdíremen, Akçahan; Chea, Aun; Topal, Fevzi

doi:10.3109/14756360902932792

Cited by 132 publications

(82 citation statements)

References 47 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Phenolics are thought to be an integral part of both human and animal diets [35][36][37][38] . The majority of natural antioxidant compounds are phenolics, and the most important groups of natural antioxidants are flavonoids, which include flavanones, flavanols and flavanonols [39][40][41][42][43] .…”

Section: Introductionmentioning

confidence: 99%

Quercetin protects rat skeletal muscle from ischemia reperfusion injury

Akdemir

Gülçın

Karagöz

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

Self Cite

View full text Add to dashboard Cite

In this study, we investigated the potential beneficial effects of quercetin on skeletal muscle ischemia reperfusion injury. Twenty-four Sprague-Dawley type rats were randomly divided into four groups. In the sham group, only gastrocnemius muscle were removed and given no quercetin. In ischemia group, all the femoral artery, vein and collaterals were occluded in the left hindlimb by applying tourniquate under general anaesthesia for three hours but reperfusion was not done. In the Quercetin + Ischemia reperfusion group, quercetin (200 mg kg À1 dose orally) was given during one-week reoperation and later ischemia reperfusion model was done. Finally, gastrocnemius muscle samples were removed to measure biochemical parameters. The biomarkers, MDA levels, SOD, CAT and GPx activities, were evaluated related to skeletal muscle ischemia reperfusion injury. MDA levels reduced and SOD, CAT and GPx activities increased significantly in Quercetin + Ischemia reperfusion group. Results clearly showed that Quercetin have a protective role against oxidative damage induced by ischemia reperfusion in rats.

show abstract

Section: Introductionmentioning

confidence: 99%

Quercetin protects rat skeletal muscle from ischemia reperfusion injury

Akdemir

Gülçın

Karagöz

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…The antioxidant profile of any chemical/plant can be simply evaluated using DPPH free radical scavenging assy. Oxidative stress due to free radicals formation has been recognized in the pathophysiology of several chronic pathological complex conditions such as atherosclerosis, stroke, diabetes, Alzheimer's disease and cancer [32][33][34] . Therapeutic modality that has the tendency to counteract these agents are extensively used in combination therapy for the effective management of such conditions 35,36 .…”

Section: Resultsmentioning

confidence: 99%

Isolation of a new bioactive cinnamic acid derivative from the whole plant of Viola betonicifolia

Muhammad

Saeed

Adhikari

et al. 2012

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

“…In addition to flavonoids, other phytochemicals such as terpenoids, alkaloids, and terpenes also exhibit significant antioxidant potential and also chemoprotective [31][32][33][34][35], thus the observed bioactivity in the current experiment could be attributed to synergy between the various phytochemicals that have been detected in Costus afer [4,5,8]; however, further experiments are required to evaluate this possibility.…”

Section: Tissue Damage Is Reduced By Costus Afermentioning

confidence: 88%

Paracetamol and Hydrogen peroxide-induced tissue alterations are reduced by Costus afer extract

Okoko¹

2018

Am J Res Med Sci

View full text Add to dashboard Cite

Aim/Objective: To evaluate the effect of the methanolic extract of Costus afer stem on paracetamol-induced tissue injury in rats (in-vivo) and its ability to reduce hydrogen peroxide-induced erythrocyte damage (in-vitro). Methods: Twenty-five rats were acclimatized for two weeks and randomized into five groups. Group I was untreated controls, while each rat in groups III-V was given a single intraperitoneal administration of paracetamol (800 mg/kg b.w.). Prior to the administration of paracetamol, rats in groups II and IV were orally given Costus afer extract at 200 mg/kg b.w, while rats in group V were given 400 mg/kg b.w. extract once daily for four days. In the other experiment, hydrogen peroxide was used to induce erythrocyte damage (after isolating erythrocytes from whole blood) and subsequently incubated with the extract at different concentrations. Markers for tissue and erythrocyte damage were assessed in serum, tissue homogenates, and erythrocytes. Results: Paracetamol caused marked elevations (p < 0.05) in the levels of alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase (ALP), urea, and creatinine in serum. The levels of thiobarbituric acid reactive species (TBARS) in both the liver and the kidney were also raised when compared to untreated control (p < 0.05) while the activities of superoxide dismutase (SOD) and catalase (CAT) were reduced when compared to untreated controls (p < 0.05). Pretreatment of rats with Costus afer extract (p.o.) caused a significant reduction in the serum levels of ALT, AST, ALP, urea, creatinine, and tissue TBARS closer to the control values (p < 0.05). Pretreatment of rats with the plant extract also increased the activities of SOD and CAT in both the liver and the kidney. Apart from the levels of TBARS in the liver and CAT in the kidney, rats pretreated with 400 mg/kg b.w. extract showed greater response than in pretreatment with 200 mg/kg b.w. The extract also reduced the hydrogen peroxide-induced erythrocyte damage assessed as hemolysis and lipid peroxidation, which was concentration-dependent (p < 0.05). Conclusion: This indicated that Costus afer possesses the ability to protect the various tissues against chemical-induced injury. ARTICLE HISTORY

show abstract

Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline

Cited by 132 publications

References 47 publications

Quercetin protects rat skeletal muscle from ischemia reperfusion injury

Quercetin protects rat skeletal muscle from ischemia reperfusion injury

Isolation of a new bioactive cinnamic acid derivative from the whole plant of Viola betonicifolia

Paracetamol and Hydrogen peroxide-induced tissue alterations are reduced by Costus afer extract

Contact Info

Product

Resources

About