Antioxidant activity of dichloromethane fraction of Dichrocephala integrifolia in Salmonella typhi-infected rats

Fankem, Gaétan Olivier; Tagne, Michel Archange Fokam; Noubissi, Paul Aimé; Fondjo, Angèle Foyet; Kamtchouing, Idrice; Ngwewondo, Adela; Wambe, Henri; Mukam, Joseph Ngakou; Kamgang, René

doi:10.1016/j.joim.2019.09.005

Cited by 10 publications

(3 citation statements)

References 24 publications

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“…Mothana et al have shown that Dichrocephala integrifolia exhibited antiplasmodial, antileishmanial, and antitrypanosomal activity against P. falciparum , L. infantum , T. cruzi , and T. brucei ( Mothana et al, 2014 ). Fankem et al have shown that the dichloromethane fraction of D. integrifolia protects the tissue damage from S. typhi infection by preventing the oxidative reactions ( Fankem et al, 2019 ). It is seen that decoction made from the leaves of the plant is able to prevent memory impairment and improves the learning capacities in mice ( Enogieru and Momodu, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Ethnobotanical study of endemic and non-endemic medicinal plants used by indigenous people in environs of Gullele botanical garden Addis Ababa, central Ethiopia: A major focus on Asteraceae family

et al. 2022

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Gullele Botanical Garden (GBG) in Addis Ababa, Ethiopia is a joint venture of Addis Ababa government and the university. The garden has been built mainly to conserve the endemic plants and to advance the research on the endemic and non-endemic plants collected from different part of Ethiopia. Many traditional healers from the environs of GBG and different subcities of Addis Ababa depend on the garden for their practice of traditional medicine but there is no systematic documentation of the traditional medicinal knowledge of these healers. The main objective of the present study is to comprehensively document the ethnobotanical and ethnomedicinal information from the traditional healers of different ethnic and cultural groups depending on GBG and to create a database of the endemic plants used by these healers. The ethnobotanical and ethnomedicinal data obtained from 60 traditional healers have been analyzed both qualitatively and quantitatively. A total of 81 medicinal plants belonging to 47 families have been identified. Majority of the plants used belonged to Asteraceae (12) family. The most frequently used plant form and plant parts are herbs and leaves. The major method adopted by the healers for preparation and administration of traditional medicine is crushing and topical, respectively. Skin and general diseases are the most important ailments treated by the healers. The three most cited plants used to treat diseases are Echinops kebericho Mesfin (60), Hagenia abyssinica (Bruce) J.F.Gmel (60) and Laggera tomentosa (A.Rich.) Sch.Bip. ex Oliv. & Hiern (58). The present study is the first systematic, qualitative, and quantitative ethnobotanical analysis and documentation done on the use of the medicinal plants from GBG for traditional medicine. In addition, our study reveals that E. kebericho is endemic and endangered plant and is highly used in traditional medicine. Therefore, GBG authorities should take steps for the propagation and restoration of this plant. Further it is suggested that the pharmacological properties of the roots and leaves of E. kebericho should be compared to find the possibility of use of leaves in place of roots for the preparation of traditional medicine which would help in conserving this endemic plant of Ethiopia.

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Section: Resultsmentioning

confidence: 99%

Ethnobotanical study of endemic and non-endemic medicinal plants used by indigenous people in environs of Gullele botanical garden Addis Ababa, central Ethiopia: A major focus on Asteraceae family

et al. 2022

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“…Secondly, NPs act through the modulation of host cells by activating or inhibiting the inflammation-associated signaling pathways of host cells infected by microorganisms, such as NF-κB/JNK/MAPK/p53, to adjust the potential of enemy-destroying and self-destructive process to a better balance (Zhou et al, 2017;Han and Guo, 2012;Pang et al, 2011). Thirdly, NPs exert protective effects on cells through antioxidant mechanisms (Alam et al, 2012;Fankem et al, 2019;Reddy et al, 2010). Lastly, NPs can induce DNA damage (Singh et al, 2018), interfere with substance meta-bolism (Agarwal et al, 2008), exert immunomodulation (Basso et al, 2020) or autophagy modulation (Kaneda et al, 1991;Laconi et al, 2014).…”

Section: Nps Against Other Infectious Pathogensmentioning

confidence: 99%

Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities

Luo

Yang

Wang

et al. 2021

Sci. China Life Sci.

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As coronavirus disease 2019 (COVID-19) threatens human health globally, infectious disorders have become one of the most challenging problem for the medical community. Natural products (NP) have been a prolific source of antimicrobial agents with widely divergent structures and a range vast biological activities. A dataset comprising 618 articles, including 646 NP-based compounds from 672 species of natural sources with biological activities against 21 infectious pathogens from five categories, was assembled through manual selection of published articles. These data were used to identify 268 NP-based compounds classified into ten groups, which were used for network pharmacology analysis to capture the most promising lead-compounds such as agelasine D, dicumarol, dihydroartemisinin and pyridomycin. The distribution of maximum Tanimoto scores indicated that compounds which inhibited parasites exhibited low diversity, whereas the chemistries inhibiting bacteria, fungi, and viruses showed more structural diversity. A total of 331 species of medicinal plants with compounds exhibiting antimicrobial activities were selected to classify the family sources. The family Asteraceae possesses various compounds against C. neoformans , the family Anacardiaceae has compounds against Salmonella typhi , the family Cucurbitacea against the human immunodeficiency virus (HIV), and the family Ancistrocladaceae against Plasmodium . This review summarizes currently available data on NP-based antimicrobials against refractory infections to provide information for further discovery of drugs and synthetic strategies for anti-infectious agents. Supporting Information The supporting information is available online at 10.1007/s11427-020-1959-5. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

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“…e population of Nepal and Yemen uses Dichrocephala integrifolia in the treatment of cancer and infectious diseases [30,31]. In Cameroon, this plant locally known as "mbag," "api," "ngninada elokn," "kévé," and "ganki" is used as a therapy for fever, diarrhea, hypertension, malaria, asthma, inflammatory diseases, stomach ulcers, memory impairment and liver dysfunctions [32][33][34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Dichrocephala integrifolia Aqueous Extract Antagonises Chronic and Binges Ethanol Feeding-Induced Memory Dysfunctions: Insights into Antioxidant and Anti-Inflammatory Mechanisms

Wanyu

Kouemou

Taïwe

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Ethanol consumption is widely accepted despite its addictive properties and its mind-altering effects. This study aimed to assess the effects of Dichrocephala integrifolia against, memory impairment, on a mouse model of chronic and binges ethanol feeding. Mice were divided, into groups of 8 animals each, and received distilled water, Dichrocephala integrifolia aqueous extract (25; 50; 100; or 200 mg/kg) or memantine (200 mg/kg) once a day, while fe, with Lieber-DeCarli control (sham group only) or Lieber-DeCarli ethanol diet ad libitum for 28 days. The Y maze and the novel object recognition (NOR) tests were used to evaluate spatial short-term and recognition memory, respectively. Malondialdehyde, nitric oxide, glutathione levels, and proinflammatory cytokines (Il-1β, TNF-α, and Il-6) were evaluated in brain homogenates following behavioral assessments. The results showed that chronic ethanol administration in mice was associated with a significant ( p < 0.001 ) reduction in the spontaneous alternation percentage and the discrimination index, in the Y maze and the NOR tests, respectively. It significantly ( p < 0.01 ) increased oxidative stress and inflammation markers levels in the brain. Dichrocephala integrifolia (100 and 200 mg/kg) as well as memantine (200 mg/kg) significantly ( p < 0.001 ) increased the percentage of spontaneous alternation and the discrimination index, in the Y maze and NOR tests, respectively. Dichrocephala integrifolia (100 and 200 mg/kg) likewise memantine (200 mg/kg) significantly ( p < 0.01 ) alleviated ethanol-induced increase, in the brain malondialdehyde level, nitric oxide, Il-1β, TNF-α, and Il-6. From these findings, it can be concluded that Dichrocephala integrifolia counteracted memory impairment, oxidative stress, and neuroinflammation induced by chronic ethanol consumption in mice.

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Antioxidant activity of dichloromethane fraction of Dichrocephala integrifolia in Salmonella typhi-infected rats

Cited by 10 publications

References 24 publications

Ethnobotanical study of endemic and non-endemic medicinal plants used by indigenous people in environs of Gullele botanical garden Addis Ababa, central Ethiopia: A major focus on Asteraceae family

Ethnobotanical study of endemic and non-endemic medicinal plants used by indigenous people in environs of Gullele botanical garden Addis Ababa, central Ethiopia: A major focus on Asteraceae family

Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities

Dichrocephala integrifolia Aqueous Extract Antagonises Chronic and Binges Ethanol Feeding-Induced Memory Dysfunctions: Insights into Antioxidant and Anti-Inflammatory Mechanisms

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