Antioxidant Activity of Different Treatments of Sesame Seeds on Lipid Profile in Rats With Atherosclerosis

Abstract

This study was carried out to investigate the antioxidant activity of different treatments of sesame seeds on lipid profile in rats with atherosclerosis. Adult male Sprague-Dawley rats (n= 72) were divided into two main groups the first main group (n=9) was fed on basal diet as a negative control group. Atherosclerosis was induced in the second main group (n = 63) which was assigned to groups 2-8. Group 2 was positive control group; the others were treated with raw, roasted and fermented sesame seeds at two levels of intake (100 and 150 gm/kg diet). At the end of the experimental period (8 weeks), feed intake was recorded and feed efficiency ratio was calculated Heart and aorta from all rats were collected for histological studies. Blood samples were collected for estimating lipid profile and its fractions. Results revealed that treatment of atherosclerotic rats with raw, roasted and fermented sesame seeds at the two levels of intake improved daily food intake, body weight gain and feed efficiency ratio. Supplementation with all forms of sesame seeds improved blood lipids parameters and atherogenic index. Results showed that the addition of sesame seeds led to a significant improvement in the results of histological studies which were coincided with the biochemical analysis .The present study recommends increasing the consumption of sesame seeds in different formsdue to its beneficial effects on lipid profile. Nutrition education programs are needed to clarify the importance of sesame seeds in reducing the risk of developing arteriosclerosis. Further studies are required to evaluate the health benefits of consuming fermented sesame seeds.

A comprehensive tool in recycling plant-waste of Gossypium barbadense L agricultural and industrial waste extracts containing gossypin and gossypol: hepatoprotective, anti-inflammatory and antioxidant effects

“…All determinations were carried out in triplicates are illustrated in Fig. ( 4 ).The radical scavenging model for antioxidant activity, using 1,1-diphenyl-2-picrylhydrazyl (DPPH, 250 mM), was performed according to Mohammed et al [ 25 ].…”

A comprehensive tool in recycling plant-waste of Gossypium barbadense L agricultural and industrial waste extracts containing Gossypin and Gossypol:Hepatoprotective, anti-inflammatory and antioxidant effects

“…All determinations were carried out in triplicates are illustrated in fig. (4).The radical scavenging model for antioxidant activity, using 1,1-diphenyl-2-picrylhydrazyl (DPPH, 250mM), was performed according to Mohammed et al [22].…”