Antioxidant activity of hydroxycinnamic acid derivatives in human low density lipoprotein: Mechanism and structure–activity relationship

Green and roasted coffee extracts as antioxidants in βTC3 cells with induced oxidative stress and lipid accumulation inhibitors in 3T3L1 cells, and their bioactivity in rats fed high fat diet

“…CHAs exhibit a broad range of biological activities: antibacterial, antifungal, hepatoprotective, antithrombotic, antiinflammatory and antioxidant activities [3][4][5][6][7][8]. Antioxidant activity of CHAs decrease the risk of several oxidative stress-related diseases, including atherosclerosis, some kinds of cancer and Alzheimer's disease [9][10][11]. Consumption of coffee containing CHAs and other bioactive compounds also helps to fight against obesity and limits the effects of type 2 diabetes [12,13].…”

Changes in properties of food proteins after interaction with free and β-cyclodextrin encapsulated hydroxycinnamic acids

“…They have been shown to exhibit a broad range of biological activities including: antibacterial, antifungal, hepatoprotective, antithrombotic, anti-inflammatory, hypoglycemic and antioxidant [4][5][6][7][8][9][10]. In vivo antioxidant activity of HCAs reduces the risk of several oxidative stressrelated diseases, including atherosclerosis, some kinds of cancer and Alzheimer's disease [11][12][13]. Coffee is one of the plants that accumulate HCAs in quantities sufficient to have physiological effects.…”

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“…[6] • The presence of the orthodihydroxyphenyl group (catechin fragment) is important for antioxidant activity, as well as an increase in the activity level in groups of up to three not higher than this activity. [7] • Substitution in the main fragment of the molecule of oxycinnamic acids leads to various pharmacological effects. For example, m-hydroxy or p-methoxy moieties in the cinnamic acid structure serve as important functional groups as effective insulin liberators, while 3,4-dihydroxycinnamic acid (coffee) exhibits hepatoprotective activity.…”