Antioxidant Activity of Knotwood Extractives and Phenolic Compounds of Selected Tree Species

Willför, Stefan; Ahotupa, Markku; Hemming, Jarl; Reunanen, Markku; Eklund, Patrik; Sjöholm, Rainer; Eckerman, Christer; Pohjamo, Suvi P.; Holmbom, Bjarne

doi:10.1021/jf030445h

Cited by 200 publications

(169 citation statements)

References 20 publications

Supporting

Mentioning

152

Contrasting

Order By: Relevance

“…clique clusters 1, 10, 39, and 52; Supplemental Fig. S2B), with some, such as taxifolin, quercetin, and myricetin, being efficient radical scavengers and/or antioxidants for lipid peroxidation, albeit sugar moieties can influence their antioxidant activity (Hopia and Heinonen, 1999;Willför et al, 2003). The strong up-regulation of genes encoding glutathione S-transferases (Fig.…”

Section: Discussionmentioning

confidence: 99%

A Key Role for Apoplastic H₂O₂ in Norway Spruce Phenolic Metabolism

et al. 2017

View full text Add to dashboard Cite

Apoplastic events such as monolignol oxidation and lignin polymerization are difficult to study in intact trees. To investigate the role of apoplastic hydrogen peroxide (H 2 O 2 ) in gymnosperm phenolic metabolism, an extracellular lignin-forming cell culture of Norway spruce (Picea abies) was used as a research model. Scavenging of apoplastic H 2 O 2 by potassium iodide repressed lignin formation, in line with peroxidases activating monolignols for lignin polymerization. Time-course analyses coupled to candidate substrate-product pair network propagation revealed differential accumulation of low-molecular-weight phenolics, including (glycosylated) oligolignols, (glycosylated) flavonoids, and proanthocyanidins, in lignin-forming and H 2 O 2 -scavenging cultures and supported that monolignols are oxidatively coupled not only in the cell wall but also in the cytoplasm, where they are coupled to other monolignols and proanthocyanidins. Dilignol glycoconjugates with reduced structures were found in the culture medium, suggesting that cells are able to transport glycosylated dilignols to the apoplast. Transcriptomic analyses revealed that scavenging of apoplastic H 2 O 2 resulted in remodulation of the transcriptome, with reduced carbon flux into the shikimate pathway propagating down to monolignol biosynthesis. Aggregated coexpression network analysis identified candidate enzymes and transcription factors for monolignol oxidation and apoplastic H 2 O 2 production in addition to potential H 2 O 2 receptors. The results presented indicate that the redox state of the apoplast has a profound influence on cellular metabolism.

show abstract

Section: Discussionmentioning

confidence: 99%

A Key Role for Apoplastic H₂O₂ in Norway Spruce Phenolic Metabolism

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Sitostanol, a saturated analogue to sitosterol from a byproduct of the pulp industry, is used for functional food to reduce serum cholesterol [43,44]. Bark and knots of conifers have been reported lately to contain large variety of bioactive compounds with good antioxidant activities and anti-inflammatory properties [45,46]. Knots of softwood species contain polyphenols, with lignans as the dominating group [35].…”

Section: Forests As a Source Of Bioactive Compounds And Drugsmentioning

confidence: 99%

Promoting human health through forests: overview and major challenges

Karjalainen

Sarjala²,

Raitio

2009

Environ Health Prev Med

206

117

View full text Add to dashboard Cite

This review aims to contribute to the ongoing discussion about human health, global change, and biodiversity by concentrating on the relationships between forests and human health. This review gives a short overview of the most important health benefits that forests provide to humans, and the risks that forests may pose to human health. Furthermore, it discusses the future challenges for the research on the links between forests and human health, and for delivering health through forests in practice. Forests provide enormous possibilities to improve human health conditions. The results of a vast amount of research show that forest visits promote both physical and mental health by reducing stress. Forests represent rich natural pharmacies by virtue of being enormous sources of plant and microbial material with known or potential medicinal or nutritional value. Forest food offers a safety net for the most vulnerable population groups in developing countries, and healthy forest ecosystems may also help in regulation of infectious diseases. Utilizing forests effectively in health promotion could reduce public health care budgets and create new sources of income. Main challenges to delivering health through forests are due to ecosystem and biodiversity degradation, deforestation, and climate change. In addition, major implementation of research results into practice is still lacking. Inadequate implementation is partly caused by insufficient evidence base and partly due to the lack of policy-makers' and practitioners' awareness of the potential of forests for improving human health. This calls for strong cooperation among researchers, policy-makers, and practitioners as well as between different sectors, especially between health and environmental professionals.

show abstract

“…Resin acids and lignans are also of interest due to their biological activity [20]. Their composition, distribution and roles were discussed quite early [21].…”

Section: Lignans and Resin Acidsmentioning

confidence: 99%

Screening Analyses of Pinosylvin Stilbenes, Resin Acids and Lignans in Norwegian Conifers

et al. 2006

View full text Add to dashboard Cite

Abstract:The content and distribution of stilbenes and resin acids in Scots pine (Pinus sylvestris) and spruce (Picea abies), sampled in central Norway, have been examined. The contents of pinosylvin stilbenes in pine heartwood/living knots were 0.2-2/2-8 % (w/w). No stilbenes could be detected in spruce (Picea abies). The resin acid contents of pine sapwood/heartwood and knots were 1-4 and 5-10 % (w/w), respectively. Minor amounts of resin acids (<0.2/<0.04 %w/w) were identified in spruce wood/knots. The lignan content in knots of Norwegian spruce was 6.5 % (w/w). Diastereomerically pure hydroxymatairesinol (HMR, 84 % of total lignans) was readily isolated from this source since only minor quantities (2.6 % of total lignans) of the allo-HMR diastereomer was detected. Insignificant amounts of lignans were present in the sapwood. Lignans could not be detected in the sapwood or knots of Norwegian sallow (Salix caprea), birch (Betula pendula) or juniper (Juniperus communis).

show abstract

Antioxidant Activity of Knotwood Extractives and Phenolic Compounds of Selected Tree Species

Cited by 200 publications

References 20 publications

A Key Role for Apoplastic H₂O₂ in Norway Spruce Phenolic Metabolism

A Key Role for Apoplastic H₂O₂ in Norway Spruce Phenolic Metabolism

Promoting human health through forests: overview and major challenges

Screening Analyses of Pinosylvin Stilbenes, Resin Acids and Lignans in Norwegian Conifers

Contact Info

Product

Resources

About

Antioxidant Activity of Knotwood Extractives and Phenolic Compounds of Selected Tree Species

Cited by 200 publications

References 20 publications

A Key Role for Apoplastic H2O2 in Norway Spruce Phenolic Metabolism

A Key Role for Apoplastic H2O2 in Norway Spruce Phenolic Metabolism

Promoting human health through forests: overview and major challenges

Screening Analyses of Pinosylvin Stilbenes, Resin Acids and Lignans in Norwegian Conifers

Contact Info

Product

Resources

About

A Key Role for Apoplastic H₂O₂ in Norway Spruce Phenolic Metabolism

A Key Role for Apoplastic H₂O₂ in Norway Spruce Phenolic Metabolism