Antioxidant activity of <i>Piper caninum</i> and Cyclooxygenase-2 inhibition by methoxylated flavones.

Abstract

Background: This study investigated on antioxidant activity of Piper caninum and cyclooxygenase-2 inhibition by methoxylated flavones. Materials and methods:The present study was carried out to quantify the total phenolic content and free radical scavenging activities of the crude extracts by Folin-Ciocalteu and 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay respectively. Results: Methanolic extracts of Piper caninum exhibited the highest total phenolic content and free radical scavenging activities. All the pure compounds possessed significant cyclooxygenase-2 inhibition at physiological concentrations. Conclusion: Based on in vitro and molecular docking, we therefore suggest that Piper caninum methoxylated flavones are potent inhibitors of cyclooxygenase-2 at physiological concentrations

An unprecedented chlorine-containing piperamide from Piper pseudoarboreum as potential leishmanicidal agent

“…Compound 2 is biogenetically derived from L-lysine, which is converted to piperidine, precursor of piperidone, and further catalysis by chloroperoxidase (CPO) in the last step of its biosynthesis yield 2. Moreover, compound 12 could be derived from L-phenylalanine by the typical of shikimic acid pathway through cinnamic acid (10), which is the precursor of ferulic acid (11). Precursors 10 and 11 were also isolated from the plant (Scheme 1).…”

“…In fact, these plants have been commonly used in traditional Chinese medicine, Indian Ayurvedic system and folk medicine of Latin America [3][4][5]. Furthermore, members of the genus Piper play an important role as source of therapeutic agents [6,7], biosynthesizing great chemical diversity [2,8], including alkaloids [9], flavonoids [10],…”

“…terpenoids [11], phenylpropanoids [12], phenolic acids [13] and lignans [14]. These constituents have been reported to possess antioxidant [10], anti-inflammatory [15], antitumor [16] and antiparasitic properties [13,14,17].…”

“…As part of an intensive investigation into potential leishmanicidal agents from Piper species, we report herein on the isolation and structure elucidation of a new piperamide (1), along with eleven known compounds (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)…”

Antileishmanial Activity of the Genus Piper: A Systematic Review

“…Piper is the largest genus of the family Piperaceae, with nearly 2000 species of herbs, shrubs, or small trees distributed throughout the tropical and subtropical forests, primarily in Central and South America, the Caribbean, Africa, Asia, and the Pacific Islands [10]. In fact, these plants have been commonly used in traditional medicine [8,[11][12] and are an important source of therapeutic agents [13], as they display a great chemical diversity of secondary metabolism [10,14], including alkaloids [15], flavonoids [16], terpenoids [17], phenylpropanoids [18], phenolic acids [19] and lignans [20]. These constituents have been reported to have antioxidant [15], antiinflammatory…”