Antioxidant activity of noni juice in heavy smokers

Wang, Mian Ying; Lutfiyya, M. Nawal; Weidenbacher-Hoper, Vicki; Anderson, Gary L.; Su, Chen X.; West, Brett J.

doi:10.1186/1752-153x-3-13

Cited by 52 publications

(49 citation statements)

References 30 publications

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“…Noni juice also contains a small percentage of grape juice (11%) to enhance palatability and could add or synergize with the noni juice. However, in a clinical trial using grape juice as a placebo, only noni puree resulted in the beneficial reduction of lipid peroxidation and reactive oxygen species (35). Therefore, the small percentage of other juices may not be responsible for the induction of osteogenesis in rat; however, as different outcomes were investigated, these juices may still have a partial role in osteogenesis.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Role of Noni (Morinda citrifolia) Juice for Inducing Osteoblast Differentiation in Isolated Rat Bone Marrow Derived Mesenchymal Stem Cells

Hussain¹,

Tamizhselvi²,

George³

et al. 2016

IJSC

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Background and ObjectivesMorinda citrifolia (Noni), an important traditional medicinal plant still used in patients with bone fractures or dislocation to promote connective tissue repair and to reduce inflammation. However, the effects of Noni on bone metabolism and whether it influences the osteogenic differentiation is yet to be clarified. In this study, we investigated the effect of Morinda citrifolia (Noni) juice on the proliferation rate of rat bone marrow derived mesenchymal stem cells (BMSC) and the osteoblastic differentiation as shown by alkaline phosphatase (ALP), Runt-related transcription factor 2 (Runx2) and osteocalcin (OCN) mRNA expression in vitro.Methods and ResultsTreatment with 200 μg/ml Noni juice enhanced the proliferation rate of the BMSC and also upregulated the osteogenic differentiation marker genes ALP and OCN, and Runx2 measured by RTPCR. Consistent with these results collagen scaffolds implanted in vivo, which were loaded with BMSC pre-exposed to Noni, showed increased bone density measured by computed tomography and histological analysis revealed neo-angiogenesis for bone formation.ConclusionsThese results suggest that Noni stimulates osteoblastogenesis and can be used as adjuvant natural medicine for bone diseases such as osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Assessment of the Role of Noni (Morinda citrifolia) Juice for Inducing Osteoblast Differentiation in Isolated Rat Bone Marrow Derived Mesenchymal Stem Cells

Hussain¹,

Tamizhselvi²,

George³

et al. 2016

IJSC

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“…Further, smoking history among current non-smokers has an impact, with skin autofluorescence being lower among those who have never smoked than among ex-smokers [135]. In heavy cigarette smokers, noni juice ingestion lowered plasma concentrations of superoxide anion radicals (SAR) and lipid hydroperoxides [136], as well as reduced lipid peroxidationderived DNA adducts [137]. The role of deacetylasperulosidic acid in the antioxidant activity of noni juice was demonstrated by its ability to increase superoxide dismutase and catalase activity in vivo [50].…”

Section: Antiglycation Activities Of Iridoidsmentioning

confidence: 98%

Iridoids are natural glycation inhibitors

West¹,

Deng²,

Uwaya³

et al. 2016

Glycoconj J

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Glycation of amino acid residues in proteins leads to the eventual formation of advanced glycation end products (AGEs). AGE formation significantly influences human health and the aging process. AGE accumulation rates may be slowed by modifications to lifestyle or by pharmacological strategies. But the use of therapeutic drugs is not an appropriate means of controlling AGEs within the general population. However, phytochemical constituents in plant-based foods exhibit anti-glycation activities and may be more appropriate for general consumption. Among these phytochemicals are iridoids. The anti-AGE potential of iridoids has been demonstrated in vitro and in vivo, while also revealing possible mechanisms of action. Inclusion of iridoid food sources in the diet may be a useful component of strategies intended to mitigate AGE accumulation within the body.

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“…The results of the estimation of serum biochemical markers and endogenous enzymatic and non-enzymatic antioxidants data clearly revealed that NJ and DNG significantly reduced the nephrotoxic effect induced by CIS which is confirmed by histopathological study. Natural antioxidants have been broadly used for chemo protection assuming that they detoxify ROS and prevent untoward effects produced by antineoplastic agents and other toxicants [47]. Reported that NJ has a high antioxidant potential along with cytotoxic activity on cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Chemoprotective Effect of Noni (Morinda Citrifolia L.) Fruit Juice Against Cisplatin-Induced Nephrotoxicity

Ali

Mruthunjaya

Nandini

et al. 2016

Int J Pharm Pharm Sci

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Objective: Cisplatin (CIS) consumption has become a common problem that affects the health of patients around the globe. Kidney has been suspected to be particularly susceptible to the destructive effects of CIS and nephrotoxic effects are still contentious which in turn affects the Quality of Life (QoL) of patients and increase the mortality rate. This study was conducted to investigate the nephroprotective effect of Noni Juice (NJ) and Divine Noni Gold (DNG) as herbal medicine with established antioxidant properties against the controversial nephrotoxic effect of CIS in mice. Methods:Mice were divided into four groups, each group contained six mice. Group I was kept as normal, Group II received CIS (5.0 mg/kg b. wt. i. p.) on day one for 14 d. Group III and IV received NJ (0.35 ml/mouse p. o.) and DNG (0.35 ml/mouse p. o.) respectively once daily for 14 d, Group V received CIS (5.0 mg/kg b. wt. i. p.) on day one and NJ (0.35 ml/mouse p. o.) once daily for 14 d. Similarly, Group VI received CIS (5.0 mg/kg b. wt. i. p.) on day one and DNG (0.35 ml/mouse p. o.) once daily for 14 d. On day 15 blood from all the mice was collected from the carotid vein and cardiac puncture routes, and the biochemical markers viz. lactate dehydrogenase (LDH), creatinine phosphokinase (CPK), and urea were assessed. Kidney from all the animals was isolated, and catalase (CAT), glutathione (GSH), superoxide dismutase (SOD), thiols and lipid peroxidase (LPO) were estimated.Results: CIS-induced marked kidney injury; congestion of tubules, glomerular distortion foci, thickened and blocked blood vessels. Also showed significant elevation of LDH, CPK, and urea with significant inhibition of CAT, GSH, SOD, thiols activities and simultaneously elevation of LPO level. Co-administration of NJ and DNG respectively with CIS protected kidney tissues via oxidative stress inhibition.Conclusion: NJ and DNG possess protective effect against CIS-induced cellular damage in the kidney by decreasing the level of serum biochemical markers, enhancing the level of enzymatic and non-enzymatic antioxidants and maintaining the LPO level. Results suggest that NJ and DNG have strong nephroprotective effect against CIS-induced nephrotoxicity.

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Antioxidant activity of noni juice in heavy smokers

Cited by 52 publications

References 30 publications

Assessment of the Role of Noni (Morinda citrifolia) Juice for Inducing Osteoblast Differentiation in Isolated Rat Bone Marrow Derived Mesenchymal Stem Cells

Assessment of the Role of Noni (Morinda citrifolia) Juice for Inducing Osteoblast Differentiation in Isolated Rat Bone Marrow Derived Mesenchymal Stem Cells

Iridoids are natural glycation inhibitors

Chemoprotective Effect of Noni (Morinda Citrifolia L.) Fruit Juice Against Cisplatin-Induced Nephrotoxicity

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