Antioxidant Activity of Pastinaca sativa L. ssp. sylvestris [Mill.] Rouy and Camus Essential Oil

Jianu, Călin; Goleţ, Ionuţ; Stoin, Daniela; Cocan, Ileana; Lukinich-Gruia, Alexandra Teodora

doi:10.3390/molecules25040869

Cited by 22 publications

(15 citation statements)

References 30 publications

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“…The new radicals generated by the loss of a hydrogen atom from the diallylic methylene groups attack the unsaturated β-carotene molecules, which they oxidize and partially decompose [ 59 ]. The rate of β-carotene discoloration can be decreased in the presence of antioxidants [ 31 , 60 ]. The relative antioxidant activity (RAA) of MSEO was calculated according to the following equation: RAA = A MSEO /A BHT , where A BHT is the absorption of BHT (positive control used) and A MSEO is the absorption of MSEO.…”

Section: Resultsmentioning

confidence: 99%

“…The thiobarbituric acid (TBA) test, as described by Jianu et al [ 31 ], was adopted; briefly, 2 g of each sample, benzene (5 mL), and 0.67% aqueous thiobarbituric acid solution (4 mL) were mixed and continuously homogenized for 1 h with a mechanical shaker. Subsequently, the supernatant was maintained on a hot water bath for 45 min.…”

Section: Methodsmentioning

confidence: 99%

“…The analysis was conducted using the method described by Oke et al [ 35 ], with some modifications [ 31 ]. Briefly, a β-carotene (0.5 mg) stock solution was prepared in a mixture of chloroform (1 mL), Tween 40 (200 mg), and linoleic acid (25 µL).…”

Section: Methodsmentioning

confidence: 99%

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In Silico and In Vitro Evaluation of the Antimicrobial and Antioxidant Potential of Mentha × smithiana R. GRAHAM Essential Oil from Western Romania

Jianu

Stoin

Cocan

et al. 2021

Foods

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This study was conducted to identify the volatile compounds of Mentha × smithiana essential oil (MSEO) and evaluate its antioxidant and antibacterial potential. The essential oil (EO) content was assessed by gas chromatography–mass spectrometry (GC-MS). Carvone (55.71%), limonene (18.83%), trans-carveol (3.54%), cis-carveol (2.72%), beta-bourbonene (1.94%), and caryophyllene oxide (1.59%) were the main identified compounds. The MSEO displayed broad-spectrum antibacterial effects and was also found to be the most effective antifungal agent against Candida albicans and Candida parapsilosis. The antioxidant activity of MSEO was tested against cold-pressed sunflower oil by peroxide, thiobarbituric acid, 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), and β-carotene/linoleic acid bleaching methods. The EO showed strong antioxidant effects as reflected by IC50 values of 0.83 ± 0.01 mg/mL and relative antioxidative activity of 87.32 ± 0.03% in DPPH and β-carotene/linoleic acid bleaching assays, respectively. Moreover, in the first 8 days of the incubation period, the inhibition of primary and secondary oxidation compounds induced by the MSEO (0.3 mg/mL) was significantly stronger (p < 0.05) than that of butylated hydroxyanisole. In silico molecular docking studies were conducted to highlight the underlying antimicrobial mechanism as well as the in vitro antioxidant potential. Recorded data showed that the antimicrobial activity of MSEO compounds could be exerted through the D-Alanine-d-alanine ligase (DDl) inhibition and may be attributed to a cumulative effect. The most active compounds are minor components of the MSEO. Docking results also revealed that several mint EO components could exert their in vitro antioxidant activity by employing xanthine oxidase inhibition. Consequently, MSEO could be a new natural source of antioxidants and antiseptics, with potential applications in the food and pharmaceutical industries as an alternative to the utilization of synthetic additives.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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In Silico and In Vitro Evaluation of the Antimicrobial and Antioxidant Potential of Mentha × smithiana R. GRAHAM Essential Oil from Western Romania

Jianu

Stoin

Cocan

et al. 2021

Foods

Self Cite

View full text Add to dashboard Cite

show abstract

“…Another study of phenolic content conducted some plant ethanolic extracts showed that phenolic content worked in this study may be good antioxidant agent (Koley et al, 2016). A study showed that Pastinaca genus shows phenolic content (Jianu et al, 2020). Therefore, P. zozimoides may be consumed as a natural source for antioxidant phenols and be attributed health benefits.…”

Section: Total Phenolic Contentmentioning

confidence: 62%

Antioxidant and Cytotoxic Potential of Local Endemic Plant Pastinaca zozimoides Fenzl

Düşgün

Kankılıç

İşlek

et al. 2021

Turkish JAF Sci.Tech.

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P. zozimoides is local endemic in Nigde province, Turkey. There has been no previous examination of the chemical composition and bioactivity of that plant extract. In this study, we studied total phenolic content, antioxidant properties and cytotoxic effect of methanolic extracts of plant sample. According to the Folin-Ciocalteau method, the total phenolics of the extracts were determined spectrophometric. The antioxidant activity was conducted DPPH (1,1’-diphenyl-2-picrylhydrazyl) radical scavenging method and free radical reducing power assay. The cytotoxic effect was studied using MTT assay cell viability on cancer cell lines as well as on Caco-2 cell lines. The total phenolic content of P. zozimoides extract was found 28.79±0.68 μg GAE /mg. The free radical scavenger activities of the DPPH was 31.69%±1.61, 85.15%±0.13, 86.96%±0.085 for 1, 5 and 10 mg/mL, respectively. The free radical reducing power assay was 0.375±0.52, 1.587±0.71, 1.798±0.84 for 1, 5 and 10 mg/mL compared to ascorbic acid standard. On Caco-2 cell lines, the extract of plant showed no cytotoxic potential. Because of its phenolic constituents and its antioxidant capacity it can be considered a healthy nutrient.

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“…Antioxidants can scavenge these free radicals to reduce cellular damage and prevent different diseases. Because of their beneficial effects on human health, there is widespread interest in antioxidants in both pharmaceutical and food science [35,36]. We tested the antioxidant activity of the synthetic chitosan derivatives (Figures 3-5) and very satisfactory results had been achieved.…”

Section: Antioxidant Activitymentioning

confidence: 97%

Synthesis and Characterization of N,N,N-trimethyl-O-(ureidopyridinium)acetyl Chitosan Derivatives with Antioxidant and Antifungal Activities

Zhang

Tan

et al. 2020

Marine Drugs

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Chitosan is an active biopolymer, and the combination of it with other active groups can be a valuable method to improve the potential application of the resultant derivatives in food, cosmetics, packaging materials, and other industries. In this paper, a series of N,N,N-trimethyl-O-(ureidopyridinium)acetyl chitosan derivatives were synthesized. The combination of chitosan with ureidopyridinium group and quaternary ammonium group made it achieve developed water solubility and biological properties. The structures of chitosan and chitosan derivatives were confirmed by FTIR, 1H NMR spectra, and elemental analysis. The prepared chitosan derivatives were evaluated for antioxidant property by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging ability, hydroxyl radical scavenging ability, and superoxide radical scavenging ability. The results revealed that the synthesized chitosan derivatives exhibited improved antioxidant activity compared with chitosan. The chitosan derivatives were also investigated for antifungal activity against Phomopsis asparagus as well as Botrytis cinerea, and they showed a significant inhibitory effect on the selected phytopathogen. Meanwhile, CCK-8 assay was used to test the cytotoxicity of chitosan derivatives, and the results showed that most derivatives had low toxicity. These data suggested to develop analogs of chitosan derivatives containing ureidopyridinium group and quaternary ammonium group, which will provide a new kind of promising biomaterials having decreased cytotoxicity as well as excellent antioxidant and antimicrobial activity.

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Antioxidant Activity of Pastinaca sativa L. ssp. sylvestris [Mill.] Rouy and Camus Essential Oil

Cited by 22 publications

References 30 publications

In Silico and In Vitro Evaluation of the Antimicrobial and Antioxidant Potential of Mentha × smithiana R. GRAHAM Essential Oil from Western Romania

In Silico and In Vitro Evaluation of the Antimicrobial and Antioxidant Potential of Mentha × smithiana R. GRAHAM Essential Oil from Western Romania

Antioxidant and Cytotoxic Potential of Local Endemic Plant Pastinaca zozimoides Fenzl

Synthesis and Characterization of N,N,N-trimethyl-O-(ureidopyridinium)acetyl Chitosan Derivatives with Antioxidant and Antifungal Activities

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