Antioxidant activity of some organosulfur compounds in vitro

Осипова, В. П.; Половинкина, М. А.; Gracheva, Yulia A.; Shpakovsky, D. B.; Osipova, A. D.; Берберова, Н. Т.

doi:10.1016/j.arabjc.2021.103068

Cited by 24 publications

(12 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was found that only compounds 4 and 6 with phenolic groups demonstrated a radical scavenging activity (Table 2), which indicated that these compounds act mainly through the HAT mechanism; for compound 6 the IC 50 value was 20.09 ± 0.02 µM [29]. The obtained data were consistent with the literature data, according to which sterically hindered phenols are good antioxidants due to their ability to form stable aroxyl radicals [30].…”

Section: Reducing Activity Of Compoundssupporting

confidence: 87%

“…The addition of diphenyltrisulfide 1 to the liver homogenate reduced the level of TBARS after 1 h of incubation by 64%, but the efficiency of the antioxidant action decreased after 24 h to 48%, and after 48 h to 37% without inversion of properties. In the previous research, we found that bis(3,5-di-tert-butyl-4-hydroxyphenyl) disulfide 6 exhibited a pronounced antioxidant effect at all stages of LPO, and diphenyl disulfide 5 had a prolonged prooxidant activity [29]. It was previously shown that the rate of interaction of polysulfides with peroxides was proportional to the number of sulfur atoms in the polysulfide structure [54].…”

Section: Determination Of the Accumulation Level For Tbars In The Liv...mentioning

confidence: 92%

“…The studied disulfides 4 (TCI, 98%) and 5 (Sigma Aldrich, Burlington, MA, USA, 99%) are commercially available compounds. Disulfide 6 was synthesized according to the previously described method with slight modifications [29,69].…”

Section: General Procedures and Synthesesmentioning

confidence: 99%

See 2 more Smart Citations

Antioxidant Activity and Cytotoxicity of Aromatic Oligosulfides

et al. 2022

Self Cite

View full text Add to dashboard Cite

Natural or synthetic antioxidants with biomimetic fragments protect the functional and structural integrity of biological molecules at a minimum concentration, and may be used as potential chemotherapeutic agents. This paper is devoted to in silico and in vitro evaluation of the antioxidant and cytotoxic properties of synthetic analogues of natural compounds—aromatic oligosulfides. The antiradical and SOD-protective activity of oligosulfides was demonstrated in the reaction with O2–• generated in enzymatic and non-enzymatic systems. It was found that phenol-containing disulfides significantly reduced the accumulation level of hydroperoxides and secondary carbonyl thiobarbituric acid reactive substances, which are primary products of oleic acid peroxidation. The antioxidant efficiency of bis(3,5-di-tert-butyl-4-hydroxyphenyl) disulfide increased over time due to the synergistic action of the 2,6-di-tert-butylphenol fragment and the disulfide linker. The highest cytotoxicity on the A-549 and HCT-116 cell lines was found for bis(3,4-dimethoxyphenyl) disulfide. Significant induction of apoptosis in HCT-116 cells in the presence of bis(3,4-dimethoxyphenyl) disulfide indicates the prospect of its use as an antitumor agent. The significant and moderate dependences revealed between various types of activities of the studied aromatic oligosulfides can be used in the development of a strategy for the synthesis and study of target-oriented compounds with predictable biological activity.

show abstract

Section: Reducing Activity Of Compoundssupporting

confidence: 87%

Section: Determination Of the Accumulation Level For Tbars In The Liv...mentioning

confidence: 92%

See 1 more Smart Citation

Antioxidant Activity and Cytotoxicity of Aromatic Oligosulfides

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, the main food sources of OSCs belong to the Allium (garlic, onion) and Brassica (broccoli, cabbage, cauliflower) genera [ 142 ] and are responsible for the typical flavor of these matrices. This group, that mainly includes isothiocyanates, indoles, allylic sulfur compounds, and sulfones, is well known to possess several biological activities, such as antioxidant, anticancer, antimicrobial, and anti-inflammatory [ 143 , 144 ]. Among the possible mechanisms considered to be involved in the anti-inflammatory activity, inhibition of NLRP3 activation has been demonstrated to be the action mode of some OSCs.…”

Section: Food Components As Nlpr3 Modulatorsmentioning

confidence: 99%

Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation

et al. 2022

View full text Add to dashboard Cite

Inflammasomes are key intracellular multimeric proteins able to initiate the cellular inflammatory signaling pathway. NLRP3 inflammasome represents one of the main protein complexes involved in the development of inflammatory events, and its activity has been largely demonstrated to be connected with inflammatory or autoinflammatory disorders, including diabetes, gouty arthritis, liver fibrosis, Alzheimer’s disease, respiratory syndromes, atherosclerosis, and cancer initiation. In recent years, it has been demonstrated how dietary intake and nutritional status represent important environmental elements that can modulate metabolic inflammation, since food matrices are an important source of several bioactive compounds. In this review, an updated status of knowledge regarding food bioactive compounds as NLRP3 inflammasome modulators is discussed. Several chemical classes, namely polyphenols, organosulfurs, terpenes, fatty acids, proteins, amino acids, saponins, sterols, polysaccharides, carotenoids, vitamins, and probiotics, have been shown to possess NLRP3 inflammasome-modulating activity through in vitro and in vivo assays, mainly demonstrating an anti-NLRP3 inflammasome activity. Plant foods are particularly rich in important bioactive compounds, each of them can have different effects on the pathway of inflammatory response, confirming the importance of the nutritional pattern (food model) as a whole rather than any single nutrient or functional compound.

show abstract

“…Polyphenol and flavonoids boost glucose uptake by increasing GLUT-2 expression in pancreatic β-cells, increasing insulin release, and encouraging GLUT-4 translocation, which can improve glucose uptake by muscle, liver, and adipose tissue, according to our findings. 29 Flavonoids also duplicate pancreatic β-cells, inhibit α glucosidase and β amylase, diminish aldose reductase, improve calcium ion absorption, slow stomach emptying, and inhibit aldose reductase. 30 Numerous biological functions of EEAA were expressed in Figure 6.…”

Section: Discussionmentioning

confidence: 99%

In vivo and in vitro Hyperglycaemic Screening of Adenocalymma alliaceum Miers, A Promising Herb

Chutia¹,

Tyagi²,

Bhuyan³

et al. 2022

Ind. J. Pharm. Edu. Res

View full text Add to dashboard Cite

Background: Ajos sacha is a shrubby herb and has attracted scientists' attention due to its antioxidative, antineoplastic, larvicidal, and antibacterial properties. Hence, Ajos sacha assessed in vitro and in vivo diabetes protective properties. Materials and Methods: The methodology started with the quantitative phytochemical estimation of ethanolic extract of Adenocalymma alliaceum (EEAA). Then, the extract was studied for cytotoxicity, glucose utilization, and GLUT-4 redistribution. In vivo study, comprising six groups of Wistar rats. Different parameters of diabetes, antioxidant properties, and lipid profile were performed. Results: Phytochemical screening demonstrated positive results in phenolic compounds, tannins, and flavonoids. The EEAA found a minimal level of toxicity, with no dosages tested causing 50% cell death. EEAA had shown GLUT-4 redistribution assay in a dose-dependent manner on cell line procedure. After NOAEL on acute toxicity, glucose level, metabolic symptoms, serum creatinine, serum urea, and lipid profile were normal under EEAA treatment, and bodyweight, high-density lipoprotein, and protein levels increased. The liver homogenate included more antioxidative enzymes such as glutathione, catalase, and superoxide dismutase. The histopathological analysis also reveals EEAA's ability to protect pancreatic β-cell from damage. Conclusion: The current investigation found the blossoms of Ajos sacha to restore glucose abnormalities in the body.

show abstract

Antioxidant activity of some organosulfur compounds in vitro

Cited by 24 publications

References 58 publications

Antioxidant Activity and Cytotoxicity of Aromatic Oligosulfides

Antioxidant Activity and Cytotoxicity of Aromatic Oligosulfides

Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation

In vivo and in vitro Hyperglycaemic Screening of Adenocalymma alliaceum Miers, A Promising Herb

Contact Info

Product

Resources

About