Antioxidant activity of taxifolin: an activity–structure relationship

Abstract

Taxifolin is a kind of flavanonol, whose biological ability. The objectives of this study were to investigate the antioxidants and antiradical activities of taxifolin by using different in vitro bioanalytical antioxidant methods including DMPD√(+), ABTS√(+), [Formula: see text], and DPPH√-scavenging effects, the total antioxidant influence, reducing capabilities, and Fe(2+)-chelating activities. Taxifolin demonstrated 81.02% inhibition of linoleic acid emulsion peroxidation at 30 µg/mL concentration. At the same concentration, standard antioxidants including trolox, α-tocopherol, BHT, and BHA exhibited inhibitions of linoleic acid emulsion as 88.57, 73.88, 94.29, and 90.12%, respectively. Also, taxifolin exhibited effective DMPD√(+), ABTS√(+), [Formula: see text], and DPPH√-scavenging effects, reducing capabilities, and Fe(2+)-chelating effects. The results obtained from this study clearly showed that taxifolin had marked antioxidant, reducing ability, radical scavenging and metal-chelating activities. Also, this study exhibits a scientific shore for the significant antioxidant activity of taxifolin and its structure-activity insight.

A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury

“…The reblood supply to ischemic tissues results with the intensive formation of ROS, which causes damage to the biological molecules such as nucleic acids, membrane lipids and enzymes 40 . ROS can cause tissue damage and it leads to various diseases 5,[41][42][43][44] . ROS, which involves free radicals such as OH and O 2 À radicals, and nonfree radical species such as H 2 O 2 and singlet oxygen ( 1 O 2 ) were known as different forms of activated oxygen [45][46][47][48] .…”

“…Skeletal muscle I/R can start numerous detrimental events in tissue such as release and production of oxygen-derived radicals by the cells when exposed to ischemia, degradation of phospholipids by peroxidation, damage in endothelial and parenchymal cells, cytosolic calcium overload and edema due to increased permeability in the microcirculation 2 . Reactive oxygen species (ROS) are known as reactive oxygen derivatives occurred from free radicals such as superoxide anion radicals (O À 2 ) and hydroxyl radicals (OH ) [3][4][5][6] . ROS assault to membrane lipids and this event results in lipid peroxidation [7][8][9][10] .…”

Quercetin protects rat skeletal muscle from ischemia reperfusion injury

“…A huge number of consecutive events are initiated by free oxygen radicals. Free radicals intrinsically exist in living organisms; however, much amount of free radicals and lipid peroxides can lead to tissue damage, cell death or degenerative processes, including aspects of ageing, inflammation, neural disorders, cancer, and the circulatory system diseases by oxidise biomolecules and they are mainly responsible for oxidative stress [6][7][8] . Free radicals can change the structures of cellular molecules such as DNA, proteins, lipids and carbohydrates [9][10][11][12] .…”

KOMPONEN GIZI, AKTIVITAS ANTIOKSIDAN DAN KARAKTERISTIK SENSORI BUBUK FUNGSIONAL LABU KUNING (Cucurbita moschata) DAN TEMPE

“…Kedua persamaan linear yang dihasilkan dari tiap titik persen penghambatan menghasilkan rata-rata nilai IC 50 bubuk fungsional sebesar 6765,88 ppm. Nilai IC 50 menyatakan kemampuan pangan dalam menangkal 50% senyawa radikal, semakin rendah nilai IC 50 maka semakin tinggi kemampuan bahan sebagai antioksidan (Topal et al 2015).…”

“…Menurut Rustina et al 2016, suatu zat dikatakan memiliki aktivitas antioksidan lemah jika nilai IC 50 dari senyawa tersebut lebih dari 150 mcg/ml atau setara dengan 150 ppm. Meskipun termasuk kategori lemah kemampuan antioksidan bubuk fungsional ini lebih tinggi dari bubuk labu kuning dengan nilai IC 50 sebesar 9.900 ppm (Trisnawati et al 2014) (Mursyid 2014).…”