Antioxidant, analgesic and anti-inflammatory activities of the leafy stems of Waltheria indica L. (Sterculiaceae)

Abstract

Aim of the study:The existence of numerous side effects following the use of anti inflammatory drugs has led to the present study about Waltheria indica (Sterculiaceae), prescribed in the treatment of many inflammatory diseases component to discover phytomedicines secondary effects mitigated. Materials and methods: The chemical principles have been demonstrated by test characterization in liquid medium according the method of Ciulei (1949).In vivo, the model of edema induced by carrageenan to cause inflammation and the model of acetic acid induced pain were used to assess the anti-inflammatory and analgesic activities of the extract. In vitro, the effects of the aqueous extract on the DPPH°° radical, the lipoxygenase and lipid peroxidation has been demonstrated. Results: Phytochemical study of leafy stems of the plant showed the presence of tannins, flavonoids, sterols, triterpenes, saponins, reducing compounds, coumarins etc. In vivo, the results showed the aqueous extract and anti-edematous effects of the analgesic of the plant. In vitro, the results revealed the aqueous extract of W. indica inhibited the radical of DPPH°°, the lipoxygenase and the lipid peroxidation. Conclusion:The presence of chemical compounds and biological properties obtained justify the contribution of the plant in traditional medicine for the treatment of diseases with inflammatory component.

Composition, Seasonal Variation, and Biological Activities of Lantana camara Essential Oils from Côte d’Ivoire

“…Quercetin (Sigma-Aldrich) was used as a standard inhibitor at the same concentration as the essential oils. Inhibition of LOX was calculated using the following equation [86].…”

Ethnobotanical, phytochemistry, and pharmacological property of Waltheria Indica Linn

“…The phytochemical analysis of the perennial plant W. indica showed the presence of different chemical groups like flavonoids, alkaloids, terpenes, sterols, tannins, cardiac glycosides, saponins, anthraquinones, and carbohydrates (Table 1) at various degrees in the whole plant [9,11,43,53].…”

“…Pet ether, methanol leaf extracts of the W. indica, and aqueous extract of stems with leaves also showed dose-related inhibition of acute and chronic inflammation in Carrageenan induced edema. The effect may be due to inhibition of histamine, serotonin, bradykinin, prostaglandin, and cyclooxygenase (COX) products [9,70,71]. Significant reduction in the pellet weight of cotton pellet granuloma test models was also observed after treatment with methanolic leaf extracts [71].…”

“…Based on the etic approach, evidence on the pharmacological property of W. indica are available [6][7][8][9]. Still, anti-cataract [10], anti-diabetics [11], asthma [6], anemia [12], aphrodisiac [13], and anti-cancer activity [14] have to be evaluated for a detailed understanding of its mechanism and to utilize them in new drug designing process.…”

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“…Waltheria indica L. is a highly valued medicinal plant used to treat the cancer 3,4 , malaria 5 and viral 6 diseases. It also possesses the antimicrobial 7 , antioxidant 8 , antiinflammatory 8 and analgesic 8 actions.…”