Antioxidant and analgesic potential of butorphanol in dogs undergoing ovariohysterectomy

Gültiken, Nilgün; Gürler, Hande; Yarım, Gül Fatma; Binli, Firdevs; Tuncay, Müge; Büyükbudak, Fatih; Gökçeoğlu, Ayris; Anadol, Elvan

doi:10.1016/j.theriogenology.2022.07.002

Cited by 4 publications

(5 citation statements)

References 31 publications

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“…(Afifah et al 2019 ) illustrated that the process of wound healing does not induce pain. On the contrary, (Gültiken et al 2022 ) mentioned that postoperative pain might cause postoperative complications such as prolonged recovery time or delayed wound healing, therefore in this study, butorphanol was administrated for 3 days post-wound induction.…”

Section: Discussionmentioning

confidence: 93%

Acellular bovine pericardium as a biological dressing for treatment of cutaneous wounds of the distal limb in donkeys (Equus Asinus)

et al. 2022

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This research was performed to determine the impact of repeated topical dressing with acellular bovine pericardium (ABP) on healing distal limb wounds in donkeys. Twelve male clinically healthy donkeys were subjected to general anesthesia, and full-thickness wounds of six cm2 (2 × 3 cm) were created on the middle dorsolateral surface of the metacarpi. Two defects were made on each donkey’s forelimbs; the right limb was considered a control wound, and the left one was considered a treated wound. Moreover, the control wounds were irrigated with saline every three days postoperatively and bandaged with a standard dressing. The treated wounds were covered with ABP dressings. The ABP dressing was reapplied thrice at 7-, 14- and 21-days post-wound induction. In addition, the wound healing process was monitored clinically, histopathologically, and immunohistochemically of tissue as growth factor-β1, epidermal growth factor receptor, and vascular endothelial growth factor. Besides, the gene expression profile of angiogenic and myofibroblastic genes was applied as vascular endothelial growth factor-A, collagen type 3α1, fibroblast growth factor 7, and the transforming growth factor-β1.The results revealed that the wounds treated with ABP healed more quickly than the control wounds. Additionally, the mean days required for healing were significantly shorter in the ABP-treated wounds (p < 0.05; 69.5 ± 1.6) compared to control wounds (86.3 ± 3). Furthermore, immunohistochemical and gene expression analyses were significantly improved in ABP wounds than in control wounds. In conclusion, ABP is considered a natural biomaterial and promotes the healing of distal limb wounds in donkeys if applied weekly during the first three-week post-wound induction.

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Section: Discussionmentioning

confidence: 93%

Acellular bovine pericardium as a biological dressing for treatment of cutaneous wounds of the distal limb in donkeys (Equus Asinus)

et al. 2022

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“…Although the topic has been largely studied before, the results of different anesthetic agents' effects on oxidative stress are confusing. The veterinary literature states that butorphanol has mostly antioxidant effects [28,29]. Kang et al concluded that butorphanol slowed down radical attacks against B-phycoerythrin as an antioxidant [22].…”

Section: Discussionmentioning

confidence: 99%

“…The MEDBUT anesthetic combination did not even significantly differ from methadone-medetomidine [41]. Gültiken et al, on the other hand, concluded that butorphanol might not provide sufficient analgesia even in routine surgical procedures [29]. Anesthesia and its efficiency are usually evaluated by measuring cardiorespiratory parameters.…”

Section: Discussionmentioning

confidence: 99%

“…Volatile anesthetics, like isoflurane or sevoflurane, have been proven to be antioxidants with anti-inflammatory properties, too [1,19,23,26,27]. Butorphanol has antioxidant properties in dogs as well as racoons [22,28,29]. Butorphanol and fentanyl combination was even shown to contribute to the protection of myocardial ischemia/reperfusion injury, counteracting oxidative stress in rats [30].…”

Section: Introductionmentioning

confidence: 99%

“…The action of butorphanol and buprenorphine has been previously compared in studies. It was concluded that buprenorphine is the superior analgesic in dogs; therefore, it is used more commonly in surgical procedures [12,29]. Adverse effects observed after opioid administration are respiratory depression and mild cardiovascular changes such as bradycardia and hypotension [12].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Medetomidine–Butorphanol and Medetomidine–Buprenorphine on Oxidative Stress and Vital Parameters in Dogs Undergoing Ovariohysterectomy

Burbaitė,

Čechovičienė,

Sarapinienė

et al. 2024

Animals

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Oxidative stress (OS) is caused by an imbalance between the production of oxygen-containing free radicals and their elimination. General anesthesia increases the production of reactive oxygen species (ROS) and therefore causes oxidative stress. Our objective was to determine the effects of medetomidine–butorphanol (MEDBUT) and medetomidine–buprenorphine (MEDBUP) on oxidative stress and cardiorespiratory parameters in dogs undergoing ovariohysterectomy (OHE). Ten healthy female dogs were randomly assigned to two groups: the MEDBUT group (n = 5) received medetomidine and butorphanol, while the MEDBUP group (n = 5) received medetomidine and buprenorphine. OS was evaluated by measuring total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) during five different time points (from the administration of anesthetic drugs to 2 h after surgery). The observed vital cardiorespiratory parameters included heart rate (HR), respiratory rate (fR), noninvasive systolic (SAP) and diastolic (DAP) arterial blood pressures, oxygen saturation (SpO2), end-tidal CO2 (EtCO2), and body temperature (BT). Cardiorespiratory parameters were altered at a significantly greater degree in animals sedated with MEDBUT (p < 0.05). The administration of medetomidine–butorphanol was more likely to increase OS parameters, while medetomidine–buprenorphine showed decreased levels of oxidative stress throughout the study.

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Opioid Agonists and Antagonists

Lerche

2024

Pharmacology in Veterinary Anesthesia and Analgesia

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Antioxidant and analgesic potential of butorphanol in dogs undergoing ovariohysterectomy

Cited by 4 publications

References 31 publications

Acellular bovine pericardium as a biological dressing for treatment of cutaneous wounds of the distal limb in donkeys (Equus Asinus)

Acellular bovine pericardium as a biological dressing for treatment of cutaneous wounds of the distal limb in donkeys (Equus Asinus)

Effects of Medetomidine–Butorphanol and Medetomidine–Buprenorphine on Oxidative Stress and Vital Parameters in Dogs Undergoing Ovariohysterectomy

Opioid Agonists and Antagonists

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