Antioxidant and anti-aging activities of Laminaria japonica polysaccharide in Caenorhabditis elegans based on metabonomic analysis

Li, Na; Li, Quancen; He, Xiaoyu; Gao, Xiaoxiang; Wu, Linxiu; Xiao, Meifang; Cai, Wenwen; Liu, Bin; Zeng, Feng

doi:10.1016/j.ijbiomac.2022.09.008

Cited by 37 publications

(29 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glycerophospholipid metabolism pathway was one of the important pathways for NYH to improve antioxidant capacity in C. elegans . Studies have found that disturbances in glycerophospholipid metabolism could lead to cardiotoxicity and gut microbiome dysbiosis (Li et al., 2022a). At the same time, normal functioning of glycerophospholipid metabolism contributed to anti‐inflammatory activity and organ protection (Wang et al., 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Nematodes were transferred daily with new NGM to ensure that nematode offspring would not have an impact on lifespan tests. Three parallel experiments were set up in each experimental group, with 30 nematodes per NGM (Li et al., 2022a).…”

Section: Methodsmentioning

confidence: 99%

“…Nematodes were transferred to M9 buffer (200 μL) containing H2DCF‐DA (20 μL) and incubated for 30 min at room temperature in the dark. After washing with M9 buffer three times, the fluorescence intensity was measured and calculated using a microplate reader at excitation wavelength and emission wavelength of 485 and 530 nm respectively (Li et al., 2022a).…”

Section: Methodsmentioning

confidence: 99%

“…The experiment was divided into four groups: normal group (NFD); NYH low-dose group (NYH was dissolved in OP50 solution to form 80 lg mL À1 NYH-OP50 solution) (NYH-L); NYH medium-dose group (NYH was dissolved in OP50 solution to form 160 lg mL À1 NYH-OP50 solution) (NYH-M); and NYH high-dose group (NYH was dissolved in OP50 solution to form 320 lg mL À1 NYH-OP50 solution) (NYH-H). Three parallel experiments were set up in each experimental group (Li et al, 2022a(Li et al, , 2022b.…”

Section: The Strain and Experimental Design Of C Elegansmentioning

confidence: 99%

See 3 more Smart Citations

Antioxidative and anti‐ageing effects of nucleotide‐rich yeast hydrolysate by modulating metabolites in Caenorhabditis elegans based on metabonomic analysis

Cai

et al. 2023

Int J of Food Sci Tech

Self Cite

View full text Add to dashboard Cite

Summary In the food industry, yeast was used to regulate food flavour and produce fermented products. In recent years, research has found that yeast contains amino acids, peptides and other active substances, but there was little research on its improvement of health benefits. In this study, the antioxidant and anti‐ageing activities of nucleotide‐rich yeast hydrolysates (NYH) were explored in Caenorhabditis elegans nematode model system, it was found that the lifespan, anti‐heat stress and anti‐acute oxidative stress were enhanced in C. elegans supplemented with NYH by up‐regulating the activity of antioxidant enzymes and down‐regulating the level of MDA and ROS. The mRNA expression level such as age‐1 and daf‐2 was significantly down‐regulated. In addition, the antioxidant and anti‐ageing activities of NYH were exerted mainly through tyrosine metabolism, glycerophospholipid metabolism and glutathione metabolism metabolic pathways. These results showed that NYH had the potential of antioxidation and anti‐ageing, which provided a possibility for the development of yeast products as a functional food in food science.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: The Strain and Experimental Design Of C Elegansmentioning

confidence: 99%

See 2 more Smart Citations

Antioxidative and anti‐ageing effects of nucleotide‐rich yeast hydrolysate by modulating metabolites in Caenorhabditis elegans based on metabonomic analysis

Cai

et al. 2023

Int J of Food Sci Tech

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the field of food nutrition, C. elegans has attracted attention as a biological model in recent years, especially in the aspects of anti‐oxidation, Antiaging and prevention of neural related diseases. N. Li, Li, He, et al (2022) found that Laminaria japonica polysaccharide played an anti‐oxidation and Antiaging role by increasing the level of antioxidant enzymes and decreasing the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in C. elegans . Teng et al (2022) explored the insulin resistance activity of Rhodiola rosea and its major compounds in C. elegans .…”

Section: Introductionmentioning

confidence: 99%

Application of Caenorhabditis elegans in the evaluation of food nutrition: A review

Xiao

et al. 2023

eFood

Self Cite

View full text Add to dashboard Cite

At present, more and more people are suffering from various diseases and it is particularly important to find a suitable biological model to evaluate the prevention and treatment effects of various drugs and active ingredients on diseases. In all biological models, Caenorhabditis elegans is a kind of organism that is easy to observe and cultivate, has a clear genetic background and a high degree of signal pathway conservation with humans. A variety of active ingredients such as polyphenols, polysaccharides, polypeptides, and vitamins exist from natural products, which has extremely high physiological functions and medicinal values. It is highly reliable to evaluate the trophic and functional properties of the active ingredients from natural products in C. elegans. The functional properties of the active ingredients from natural products such as antiaging, anti-oxidation, regulating lipid metabolism, preventing and treating Alzheimer's disease in C. elegans were clarified in this review. At the same time, its possible pathways were summarized. The literature revealed that it had great effect to evaluate the nutrition and functionality of the active ingredients from natural products in C. elegans. Finally, the shortcomings in this field and suggestions for further improvement in this field have been emphasized.

show abstract

Response Surface Optimization of Polysaccharides from Jaboticaba (Myrciaria cauliflora [Mart.] O.Berg) Fruits: Ultrasound‐Assisted Extraction, Structure Properties, and Antioxidant/Hypoglycemic Activities

Zhang,

Wang

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

Ultrasound‐assisted extraction (UAE) method proves to be more effective compared to traditional extraction methods. In the present study, response surface methodology (RSM) was used to determine the optimal process parameters for extracting polysaccharides (U‐MCP) from jaboticaba fruit using UAE. The optimum extraction conditions were ultrasonic time 70 min, extraction temperature 60°C, and power 350 W. Under these conditions, the sugar content of U‐MCP was 52.8%. The molecular weights of the ultrasound‐assisted extracted U‐MCP ranged from 9.52×102 to 3.275×103 Da, and consisted of five monosaccharides including mannose, galacturonic acid, glucose, galactose, and arabinose. Moreover, in vitro antioxidant and hypoglycaemic assay revealed that U‐MCP has prominent anti‐oxidant activities (1,1‐diphenyl‐2‐picryl‐hydrazyl (DPPH) radicals, hydroxyl radicals and 2,2′‐Azinobis (3‐ethylbenzothiazoline‐6‐sulfonic Acid Ammonium Salt) (ABTS) radicals scavenging activities) and hypoglycemic activities (α‐amylase and α‐glucosidase inhibition activities).

show abstract

Antioxidant and anti-aging activities of Laminaria japonica polysaccharide in Caenorhabditis elegans based on metabonomic analysis

Cited by 37 publications

References 57 publications

Antioxidative and anti‐ageing effects of nucleotide‐rich yeast hydrolysate by modulating metabolites in Caenorhabditis elegans based on metabonomic analysis

Antioxidative and anti‐ageing effects of nucleotide‐rich yeast hydrolysate by modulating metabolites in Caenorhabditis elegans based on metabonomic analysis

Application of Caenorhabditis elegans in the evaluation of food nutrition: A review

Response Surface Optimization of Polysaccharides from Jaboticaba (Myrciaria cauliflora [Mart.] O.Berg) Fruits: Ultrasound‐Assisted Extraction, Structure Properties, and Antioxidant/Hypoglycemic Activities

Contact Info

Product

Resources

About