Antioxidant and anti-diabetic activities in commercial and homemade pomegranate molasses in Lebanon

Dargham, Mira Bou; Boumosleh, Jocelyne Matar; Farhat, Antoine; Abdelkhalek, Salwa; Bou-Maroun, Elias; Hosry, Leina El

doi:10.1016/j.fbio.2021.101540

Cited by 7 publications

(13 citation statements)

References 34 publications

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“…The phenolic compounds' potential candidates have a significant influence on antioxidant activities. The differences detected between the results presented in the current study and the results in the literature are due to pomegranate variety, the degree of ripeness, growing conditions, fertilizers, soil type, season, geographic origin, storage conditions, diseases, extraction evaporation, and heating methods [3].…”

Section: Antioxidant Activitycontrasting

confidence: 98%

“…Pomegranates are considered an ancient fruit, which can be grown widely in semi-arid land, arid land, and poor soil, with good yields. They can thrive in low moisture and tolerate saline water; therefore, they are broadly spread and cultivated throughout the world [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Pomegranates have been extensively used as a source of folk medicine for a long time. Recently, researchers have shown that pomegranates have many potential beneficial health effects, including anti-diabetic, antioxidant, anti-carcinogenic, anti-inflammatory, anti-diarrheal, anti-microbial, and neuroprotective activities [ 2 , 3 , 12 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Several investigations have been carried out regarding the physicochemical and biochemical effects, total flavonoid and phenolic content, antioxidant activities, and biological activities of PJC [ 2 , 3 , 12 , 14 ]. Nevertheless, as far as we know, several of the bioactivities of PJC investigated in the current study have not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant, Anti-Inflammatory, Antimicrobial, and Anticancer Activities of Pomegranate Juice Concentrate

et al. 2023

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Pomegranate juice concentrate (PJC) is a rich source of polyphenols, which exhibit significant antioxidant activity and potential health benefits for disease prevention and therapy. In this study, the polyphenolic profile of PJC was investigated for the first time, and it was found that PJC can inhibit oxidative damage to bovine serum albumin (BSA) and deoxyribonucleic acid (DNA), as well as acetylcholinesterase, α-amylase, and tyrosinase activities. The primary polyphenols identified in PJC were 4-Hydroxy-3-Methoxybenzoate, epicatechin, catechin, rutin, ferulic acid, P-coumaric acid, and cinnamic acid. Additionally, PJC demonstrated potent antibacterial effects against human pathogens such as Streptococcus mutans and Aeromonas hydrophila and dose-dependently reduced the proliferation of colorectal, breast, and hepatic cancer cells via apoptosis. Furthermore, PJC blocked B-cell lymphoma 2 (BCl-2) and the expression of a potent cyclin-dependent kinase inhibitor (P21) and enhanced tumor protein (P53) expression, compared to both untreated cells and cells treated with fluoropyrimidine 5-fluorouracil (5-FU). As a result, PJC may be a beneficial ingredient in the formulation of emerging natural-compound-based chemotherapy and functional foods and could be utilized by the food, nutraceutical, and pharmaceutical industries.

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Section: Antioxidant Activitycontrasting

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antioxidant, Anti-Inflammatory, Antimicrobial, and Anticancer Activities of Pomegranate Juice Concentrate

et al. 2023

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“…The different results could be explained by the presence of non-phenolic chelating agents such as peptides and polysaccharides. The close agreement of the results with the literature suggested that there was a weak correlation between metal chelation and total phenolic levels [ 19 , 20 ]. Several studies have been conducted in the literature to evaluate the antioxidant potential of P. abies from different countries.…”

Section: Resultssupporting

confidence: 83%

“Smart Extraction Chain” with Green Solvents: Extraction of Bioactive Compounds from Picea abies Bark Waste for Pharmaceutical, Nutraceutical and Cosmetic Uses

et al. 2022

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Secondary metabolites from the sawmill waste Picea abies bark were extracted using an innovative two-step extraction that includes a first step with supercritical CO2 (SCO2) and a second step using green solvents, namely ethanol, water, and water ethanol mixture. Maceration (M), ultrasound assisted extraction (UAE) and microwave assisted extraction (MAE) techniques were applied in the second step. A total of nineteen extract were obtained and yield were compared. Bark extracts were characterized by LC-DAD-MSn and classes of compounds were quantified as abietane derivatives, piceasides, flavonoids, and phenolics to compare different extractions. Obtained extracts were studied by in vitro assay to evaluate potential pharmaceutical, nutraceutical and cosmetic uses assessing the antioxidant activity as well as the inhibitory activity on target enzymes. Results show that the “smart extraction chain” is advantageous in term of yield of extraction and phytoconstituent concentration. SCO2 extract, presenting a unique composition with a large amount of abietane derivatives, exerted the best activity for amylase inhibition compared to the other extracts.

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Chemometrics approach for the screening of potential adulterations in pomegranate sour by infrared spectroscopy and conventional methods

Zor,

Fettahoglu,

Menevseoglu

2023

J IRAN CHEM SOC

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Antioxidant and anti-diabetic activities in commercial and homemade pomegranate molasses in Lebanon

Cited by 7 publications

References 34 publications

Antioxidant, Anti-Inflammatory, Antimicrobial, and Anticancer Activities of Pomegranate Juice Concentrate

Antioxidant, Anti-Inflammatory, Antimicrobial, and Anticancer Activities of Pomegranate Juice Concentrate

“Smart Extraction Chain” with Green Solvents: Extraction of Bioactive Compounds from Picea abies Bark Waste for Pharmaceutical, Nutraceutical and Cosmetic Uses

Chemometrics approach for the screening of potential adulterations in pomegranate sour by infrared spectroscopy and conventional methods

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