Antioxidant and anti-gout effects of orally administered zinc oxide nanoparticles in gouty mice

Kiyani, Mubin Mustafa; Butt, Maisra Azhar; Rehman, Hamza; Ali, Hussain; Hussain, Syed Ali; Obaid, Sumaiyah; Hussain, Mir Arif; Mahmood, Tariq; Bokhari, Syed Ali Imran

doi:10.1016/j.jtemb.2019.08.012

Cited by 38 publications

(24 citation statements)

References 47 publications

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“…The activities of SOD, peroxidase and CAT in liver of gout mice were recovered after oral administration of zinc oxide NPs with a diameter of 37 nm. The reaction products of ROS and thiobarbituric acid reactive substances were reduced too (Kiyani et al 2019 ). On the anti-inflammatory effect, zinc oxide NPs with particle size of 200 significantly inhibited the NF-kB pathway in the range of 0–10 μg/mL, and reduced the expression of COX-2 and iNOS (Kim and Jeong 2015 ).…”

Section: Nanoparticles With the Potential For Cartilage Protectionmentioning

confidence: 99%

“…Magnesium oxide nanoparticles promote scavenging of reactive oxygen species in cells. Magnesium oxide nanoparticles are degraded to Mg(OH) 2 in the synovial fluid, which releases magnesium ions while neutralizing the acidic environment in the joint cavity, promotes the synthesis of cartilage matrix, and inhibits the expression of osteogenic specific genes and inflammation-related genes reactive substances were reduced too (Kiyani et al 2019). On the anti-inflammatory effect, zinc oxide NPs with particle size of 200 significantly inhibited the NF-kB pathway in the range of 0-10 μg/mL, and reduced the expression of COX-2 and iNOS (Kim and Jeong 2015).…”

Section: Therapeutic Effect Of Zinc Oxide Nanoparticlesmentioning

confidence: 99%

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The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis

Luo

Zhang

Zhu

et al. 2021

Naunyn-Schmiedeberg's Arch Pharmacol

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The current understanding of osteoarthritis is developing from a mechanical disease caused by cartilage wear to a complex biological response involving inflammation, oxidative stress and other aspects. Nanoparticles are widely used in drug delivery due to its good stability in vivo and cell uptake efficiency. In addition to the above advantages, metal/metal oxide NPs, such as cerium oxide and manganese dioxide, can also simulate the activity of antioxidant enzymes and catalyze the degradation of superoxide anions and hydrogen peroxide. Degrading of metal/metal oxide nanoparticles releases metal ions, which may slow down the progression of osteoarthritis by inhibiting inflammation, promoting cartilage repair and inhibiting cartilage ossification. In present review, we focused on recent research works concerning osteoarthritis treating with metal/metal oxide nanoparticles, and introduced some potential nanoparticles that may have therapeutic effects.

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Section: Nanoparticles With the Potential For Cartilage Protectionmentioning

confidence: 99%

Section: Therapeutic Effect Of Zinc Oxide Nanoparticlesmentioning

confidence: 99%

The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis

Luo

Zhang

Zhu

et al. 2021

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Sohail MF et al [ 21 ] found that turmeric nanoparticles (T-NPs) were rich in polyphenols to achieve antioxidant effects. Kiyani et al [ 17 ] found that ZnO-NPs could effectively inhibit the formation of uric acid. Therefore, the aims of this study were to explore the effects of nanoparticles on gouty arthritis and provide evidence for the preclinical application of nanoparticles in gouty arthritis.…”

Section: Introductionmentioning

confidence: 99%

Effect of nanoparticles on gouty arthritis: a systematic review and meta-analysis

Zhu

Niu

Zhou

et al. 2023

BMC Musculoskelet Disord

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Objective The purpose of this study was to explore the effects of nanoparticles on gouty arthritis, and to provide evidence for the preclinical application of nanoparticles in gouty arthritis and ideas for nanomedicine improvement for nanoparticle researchers. Methods Five databases including the Cochrane Library, PubMed, Scopus, Web of Science, and Embase were searched for eligible studies until April 2022. The quality of the selected studies was assessed by SYRCLE’s risk of bias (RoB) tool, and the random-effects model was used to calculate the overall effect sizes of weighted mean differences (WMD). Results Ten studies met the inclusion criteria. Results showed that nanoparticles were effective in reducing uric acid levels (WMD: -4.91; 95% confidence interval (CI): − 5.41 to − 4.41; p < 0.001), but were not better than allopurinol (WMD: -0.20; 95% CI: − 0.42 to 0.02; p = 0.099). It was worth noting that the nanoparticles were safer than allopurinol. Subgroup analyses indicated that nanoparticle encapsulated substance, animal species, nanoparticle dosage, animal quantity, and animal gender were all sources of heterogeneity. Conclusion The nanoparticles are safe medications for gouty arthritis which can effectively reduce uric acid levels in rodents. Although the results are still uncertain, it is expected to have certain clinical application value. The nanoparticles may be the preclinical medications for gouty arthritis in the future.

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“…Furthermore, nanoparticles strategies are adopted to ameliorate oxidative stress in gouty pathology. 28 , 29 Still, the management of hyperuricemia and gout disorders is currently a challenging task and since inflammation is an integral etiological component underlying gout pathogenesis, and therefore it must be considered during the development of treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

Carvacrol Alleviates Hyperuricemia-Induced Oxidative Stress and Inflammation by Modulating the NLRP3/NF-κB Pathwayt

Riaz¹,

Kury²,

Atzaz³

et al. 2022

DDDT

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Purpose Gouty arthritis is generally induced by the accumulation of monosodium urate (MSU) crystals in the joints due to elevated serum uric acid levels, potentially leading to serious pathological disorders such as nephrolithiasis, renal failure, and acute gouty arthritis. In this study, we aimed to validate the anti-gout effects of carvacrol, a phenolic monoterpene. Materials and Methods Male Sprague–Dawley rats were divided into normal saline, disease group by injecting potassium mono-oxonate (PO) at a dose of 250 mg/kg, and three treatment groups, either with carvacrol 20 mg/kg or 50 mg/kg and 10 mg/kg allopurinol. The blood and tissue samples were subsequently collected and analyzed using different biochemical and histopathological techniques. Results Our results revealed a significant increase in the serum levels of oxidative stress-related markers, namely, uric acid and C-reactive protein (CRP), and NLRP3 inflammasome-dependent inflammatory mediators, including nuclear factor kappa B (NF-κB) and tumor necrosis factor-alpha (TNF-α). Carvacrol administration for seven consecutive days exhibited significant anti-hyperuricemic and anti-inflammatory effects in a dose-dependent manner. Notably, the 50 mg/kg carvacrol treatment was observed to produce results similar to the allopurinol treatment. Furthermore, the renal safety of carvacrol was confirmed by the renal function test. Conclusion Carvacrol potentially alleviates hyperuricemia-induced oxidative stress and inflammation by regulating the ROS/NRLP3/NF-κB pathway, thereby exerting protective effects against joint degeneration.

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Antioxidant and anti-gout effects of orally administered zinc oxide nanoparticles in gouty mice

Cited by 38 publications

References 47 publications

The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis

The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis

Effect of nanoparticles on gouty arthritis: a systematic review and meta-analysis

Carvacrol Alleviates Hyperuricemia-Induced Oxidative Stress and Inflammation by Modulating the NLRP3/NF-κB Pathwayt

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