Antioxidant and anti-inflammatory activities of aqueous extracts of Schizonepeta tenuifolia Briq.

Wang, Bor-Sen; Huang, Guan‐Jhong; Tai, Huo-Mu; Huang, Ming‐Hsing

doi:10.1016/j.fct.2011.12.010

Cited by 55 publications

(32 citation statements)

References 32 publications

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“…Scavenging DPPH radical activity was determined by a previously described method (Wang et al, 2012). Briefly, 0.4 mL of samples were allowed to react with 2 mL of 0.1 mM methanolic solution of DPPH radical.…”

Section: Methodsmentioning

confidence: 99%

Antioxidant and Anti-tyrosinase Activities of Phenolic Extracts from Rape Bee Pollen and Inhibitory Melanogenesis by cAMP/MITF/TYR Pathway in B16 Mouse Melanoma Cells

et al. 2017

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Rape bee pollen possesses many nutritional and therapeutic properties because of its abundant nutrimental and bioactive components. In this study, free (FPE) and bound (BPE) phenolic extracts of rape bee pollen were obtained, phenolic and flavonoid contents were determined, and composition of phenolic acids was analyzed. In vitro antioxidant and anti-tyrosinase (TYR) activities of FPE and BPE were compared, and inhibitory melanogenesis of FPE was further evaluated. Results showed FPE and BPE contain total phenolic contents of 11.76 and 0.81 mg gallic acid equivalents/g dry weight (DW) and total flavonoid contents of 19.24 and 3.65 mg rutin equivalents/g DW, respectively. Phenolic profiling showed FPE and BPE fractions contained 12 and 9 phenolic acids, respectively. FPE contained the highest rutin content of 774.87 μg/g. FPE and BPE showed the high antioxidant properties in vitro and high inhibitory activities for mushroom TYR. Higher activities of FPE than those of BPE can be attributed to difference in their phenolic compositions. Inhibitory melanogenesis activities of FPE against B16 were further evaluated. Results showed suppressed intracellular TYR activity, reduced melanin content, and promoted glutathione synthesis (p < 0.05) in FPE-treated cells. FPE reduced mRNA expression of TYR, TYR-related protein (TRP)-1 and TRP-2, and significantly suppressed cyclic adenosine monophosphate (cAMP) levels through down-regulation of melanocortin 1 receptor gene expression (p < 0.05). FPE reduced mRNA expression of microphthalmia-associated transcription factor (MITF), significantly inhibiting intracellular melanin synthesis (p < 0.05). Hence, FPE regulates melanogenesis of B16 cells involved in cAMP/MITF/TYR pathway. These results revealed that FPE can be used as pharmaceutical agents and cosmetics to protect cells from abnormal melanogenesis.

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Section: Methodsmentioning

confidence: 99%

Antioxidant and Anti-tyrosinase Activities of Phenolic Extracts from Rape Bee Pollen and Inhibitory Melanogenesis by cAMP/MITF/TYR Pathway in B16 Mouse Melanoma Cells

et al. 2017

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“…Scavenging activity on DPPH free radical by SCPE was assessed according to the method reported by Wang et al (2012) with slight modifications. Briefly, different volumes of the sample (12.5 mg/mL) were placed in a cuvette with 4.0 mL of 0.1 mM methanolic solution of DPPH radical added.…”

Section: Analysis Of Antioxidant Activities In Vitro 241 Dpph Radimentioning

confidence: 99%

Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice

Cheng

Ren

Gao

et al. 2013

Food and Chemical Toxicology

206

131

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“…For example, Schizonepeta tenuifolia rich in phenolic compounds such as diosmetin, hesperidin and luteolin possesses anti-inflammatory activities and inhibits carrageenaninduced inflammation (Wang, Huang, Tai, & Huang, 2011). In fact, polyphenolic compounds of Welsh onion green leaves may contribute to the anti-inflammatory effect of WOE.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effects of an aqueous extract of Welsh onion green leaves in mice

Wang

Huang

et al. 2013

Food Chemistry

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Antioxidant and anti-inflammatory activities of aqueous extracts of Schizonepeta tenuifolia Briq.

Cited by 55 publications

References 32 publications

Antioxidant and Anti-tyrosinase Activities of Phenolic Extracts from Rape Bee Pollen and Inhibitory Melanogenesis by cAMP/MITF/TYR Pathway in B16 Mouse Melanoma Cells

Antioxidant and Anti-tyrosinase Activities of Phenolic Extracts from Rape Bee Pollen and Inhibitory Melanogenesis by cAMP/MITF/TYR Pathway in B16 Mouse Melanoma Cells

Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice

Anti-inflammatory effects of an aqueous extract of Welsh onion green leaves in mice

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