Antioxidant and Anti-Inflammatory Activities of <i>Zingiber montanum</i> Oil in HepG2 Cells and Lipopolysaccharide-Stimulated RAW 264.7 Macrophages

Truong, Van-Long; Manochai, Benya; Pham, Thu-Trang; Jeong, Woo-Sik

doi:10.1089/jmf.2021.k.0019

Cited by 7 publications

(13 citation statements)

References 42 publications

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“…Similarly, peak 19 was tentatively annotated as 1,4,7-trimethoxytriquinacene ( 19a ). Although this annotation was consistent with previous studies [ 25 , 27 , 28 , 29 ], the present study shows that the compound corresponding to peak 19 was ( E )-1-(2′,4′,5′-trimethoxyphenyl)buta-1,3-diene ( 19 ) [ 48 ]. To avoid further misannotation, the differences in the EI mass spectrum between phenylbutadienes (identified compounds) and triquinacenes (misassigned compounds) were clarified.…”

Section: Resultssupporting

confidence: 94%

“…In particular, phenylbutenoids are major characteristic compounds of this herb and show various biological activities, including anti-asthma, anticancer, anti-inflammatory, chondroprotective, and melanogenic effects [ 18 , 19 ]. Owing to their volatility, gas chromatography–mass spectrometry (GC–MS) is often employed for the analysis of the extracts and oils of plai [ 15 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. Although these studies contributed to the elucidation of chemical constituents in plai, some peaks are still unidentified, and some discrepancies in peak annotations are found in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of the Volatile Constituents of Plai (Zingiber purpureum) by Gas Chromatography–Mass Spectrometry

Nishidono,

Saifudin,

Tanaka

2024

Molecules

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Zingiber purpureum Roscoe, known as plai in Thailand, is a perennial plant of the Zingiberaceae family and has traditionally been used in Southeast Asian countries to treat inflammation, pain, and asthma. In this study, we performed the characterization of the volatile constituents in ethyl acetate extracts of plai. Ethyl acetate extracts derived from the rhizomes of plai were subjected to gas chromatography–mass spectrometry, and the key peaks in the total ion current chromatograms were annotated or identified. In total, twenty-one compounds were identified using isolation procedures or standards, and nine compounds were annotated by comparing their Kovats retention index (RI) and electron ionization (EI) mass spectra with those in the literature. Most of the identifications were inconsistent with the tentative annotations found via library search and suggested that some peaks were incorrectly assigned in previous studies. Thus, to avoid further misannotations and contribute to the research on dereplication, the RI value, EI mass spectral data, and NMR spectroscopy data of the isolated compounds are reported.

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Section: Resultssupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Characterization of the Volatile Constituents of Plai (Zingiber purpureum) by Gas Chromatography–Mass Spectrometry

Nishidono,

Saifudin,

Tanaka

2024

Molecules

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“…The MAPK signaling pathway plays a crucial role in regulating pro-inflammatory cytokines and mediators, which is consistent with ERK, JNK and P38 proteins [ 29 ]. Truong previously reported that Zingiber montanum oil inhibited the MAPK signaling pathway in LPS-treated RAW 264.7 cells, in agreement with our results [ 28 ]. In order to investigate the possible mechanism of tobacco seed oils in LPS-induced RAW264.7 cells, the production of the MAPK pathway-related proteins, including ERK, p-ERK, JNK, p-JNK, P38, and p-p38, were determined by Western blotting analysis.…”

Section: Resultssupporting

confidence: 93%

“…These results showed that NC89 and BS4 tobacco seed oils had anti-inflammatory capacities, which were in accordance with the antioxidative results and further supported the results that tobacco seed oils could alleviate cell apoptosis. The present findings were similar to the results of Zingiber montanum oil, which also inhibited NO production in LPS-treated RAW264.7 cells, and thus exhibited anti-inflammatory activity [ 28 ].…”

Section: Resultssupporting

confidence: 89%

Chemical Composition of Tobacco Seed Oils and Their Antioxidant, Anti-Inflammatory, and Whitening Activities

Gu¹,

Zhang

Song³

et al. 2022

Molecules

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Tobacco seeds are a valuable food oil resource, and tobacco seed oil is rich in nutrients, especially polyunsaturated fatty acids. The aim of this work was to perform a comprehensive study on the chemical constituents, and the antioxidant, anti-inflammatory, and whitening activities of tobacco seed oils (NC89 and BS4). A GC/MS analysis revealed that NC89 and BS4 had 11 and 6 volatile compounds, respectively. The PUFA contents in NC89 and BS4 were 74.98% and 72.84%, respectively. These two tobacco seed oils also presented good radical scavenging capacities with the neutralization of ABTS, OH−, and superoxide (O2−) radicals in a concentration-dependent manner. Meanwhile, NC89 and BS4 inhibited reactive oxygen species (ROS) accumulation and cell apoptosis, enhanced SOD and CAT activities, and increased the GSH content in H2O2-induced HepG2 cells. In addition, NC89 and BS4 exhibited significant anti-inflammatory activities by inhibiting the expressions of NO, TNF-α, IL-1β, and IL-6 in LPS-induced RAW.264.7 cells through the regulation of the MAPK signaling pathway. Moreover, NC89 and BS4 expressed whitening activities by inhibiting tyrosinase activity and intracellular melanin production. Therefore, tobacco seed oils could be used as an important oil resource for the development of high value-added products.

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“…Terpinen-4-ol (T4O) is an active substance of the turmeric species that has exhibited anti-tumor, anti-aging, and anti-inflammatory properties in previous studies [ 6 , 7 ]. Ken et al .…”

Section: Introductionmentioning

confidence: 99%

Terpinen-4-ol inhibits the proliferation and mobility of pancreatic cancer cells by downregulating Rho-associated coiled-coil containing protein kinase 2

et al. 2022

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Terpinen-4-ol (T4O), a compound isolated from the seeds of turmeric, has exhibited anti-malignancy, anti-aging, and anti-inflammatory properties in previous studies. However, the specific effects and molecular mechanisms of T4O on pancreatic cancer (PC) cells remain largely unknown. In this study, we demonstrated that T4O markedly suppressed PC cell proliferation and colony formation in vitro and induced apoptosis. Similarly, T4O significantly inhibited the migration and invasion of PC cells in vitro . Through RNA sequencing, 858 differentially expressed genes (DEGs) were identified, which were enriched in the Rhodopsin (RHO)/ Ras homolog family member A (RHOA) signaling pathway. Rho-associated coiled-coil containing protein kinase 2 (ROCK2), a DEG enriched in the RHO/RHOA signaling pathway, was considered as a key target of T4O in PC cells; it was significantly reduced after T4O treatment, highly expressed in PC tissues, and negatively associated with patient outcome. Overexpression of ROCK2 significantly reduced the inhibitory effects of T4O on PC cell proliferation and mobility. Moreover, T4O inhibited cell proliferation in vivo and decreased the Ki-67, cell nuclear antigen, EMT markers, and ROCK2 expression. In conclusion, we consider that T4O can suppress the malignant biological behavior of PC by reducing the expression of ROCK2, thus contributing to PC therapy.

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Antioxidant and Anti-Inflammatory Activities of Zingiber montanum Oil in HepG2 Cells and Lipopolysaccharide-Stimulated RAW 264.7 Macrophages

Cited by 7 publications

References 42 publications

Characterization of the Volatile Constituents of Plai (Zingiber purpureum) by Gas Chromatography–Mass Spectrometry

Characterization of the Volatile Constituents of Plai (Zingiber purpureum) by Gas Chromatography–Mass Spectrometry

Chemical Composition of Tobacco Seed Oils and Their Antioxidant, Anti-Inflammatory, and Whitening Activities

Terpinen-4-ol inhibits the proliferation and mobility of pancreatic cancer cells by downregulating Rho-associated coiled-coil containing protein kinase 2

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