Antioxidant and Anti-inflammatory Activities of Essential Oil and Extracts of <i>Piper miniatum</i>

Salleh, Wan Mohd Nuzul Hakimi Wan; Kammil, Mohd Fariz; Ahmad, Farediah; Sirat, Hasnah Mohd

doi:10.1177/1934578x1501001151

Cited by 29 publications

(21 citation statements)

References 19 publications

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“…On the other hand, NO has been proposed as a host anti-microbial system (Akaiker and Maeda, 2000). Production of Nitric oxide is initiated in by inducible nitric oxide synthases (iNOS) in activated macrophages and neutrophils during defense and immunological reactions (Salleh et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Detection of Gamma Interferon and Some Pro-Inflammatory Cytokines in SPF Chicks Experimentally Infected with Chicken Anemia Virus

El-Samadony¹,

Mekky²,

Hafez³

et al. 2020

Adv. Anim. Vet. Sci.

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Chicken infectious anemia is one of the most economic immunosuppressive problems facing commercial poultry sector worldwide. Present study demonstrated the viral load in body organs and viral specific antibody titres of the SPF chicks experimentally infected with chicken anemia virus (CAV) strain CAV/Kal.2 and its contact group in vivo. Also, followed the emergence of lysozyme activity and nitric oxide (NO) levels, pro-inflammatory {IL-1β, IL-6 and CXCLi2 (IL-8 like chemokine)}, type I IFN (IFN-α and IFN-β) and IFN-γ cytokines. The obtained data illustrated that CAV-specific antibody development started after 7 days post infection (dpi) and reached its maximum level at 21 dpi in infected group and contact group. The CAV genome was detected in tissues of the chicks of both infected and contact groups at 7 dpi and continued for 21 dpi with 7 days intervals between sampling. Lysozyme activity and NO levels were greatly impaired in CAV infected chicks. The relative mRNA expression levels of most examined cytokines in the infected group were increased on 14 dpi compared to 7 and 21 dpi. On the other hand, CXCLi2 was generally not altered by CAV infection. The contact group showed undetermined changes in all examined cytokines (IL-1β, IL-6, CXCLi2, IFN-α, IFN-β and IFN-γ). The obtained data revealed cytokine imbalances after infection with CAV as a result of hindrance of transcription of the most of the examined cytokines. As the immunosuppressive viruses of chickens may confuse with transcription for several cytokines (IL-1β, IL-6, IFN-α, IFN-β and IFN-γ), so we suggest using this confliction in order to evaluate the immune status of chickens.

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Section: Discussionmentioning

confidence: 99%

Detection of Gamma Interferon and Some Pro-Inflammatory Cytokines in SPF Chicks Experimentally Infected with Chicken Anemia Virus

El-Samadony¹,

Mekky²,

Hafez³

et al. 2020

Adv. Anim. Vet. Sci.

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“…The sesquiterpene α-copaene, which was present at over 10% in the P. bellidifolium oil, has also been reported as a major constituent of P. boehmeriafolium oil (28.3%) from Vietnam (Hieu et al 2014). Aromadendrene was another sesquiterpene present in significant proportion in P. belldifolium and has been reported as a major constituent of the leaf oils of P. gaudichaudianum (15.55%) from the state of Rondônia, Brazil (Morais et al 2007) and P. muricatum (16.2%) from Malaysia (Salleh et al 2015). The sesquiterpene γ-cadinene has been characterized in the leaf oil of P. hispidum (25.13%) from the state of Rondônia, Brazil (Machado et al 1994) and P. cubeba (16.6%) from Indonesia (Bos et al 2007) in larger quantities than that found by us in the oil of P. consanguineum.…”

Section: Resultsmentioning

confidence: 96%

First record of the chemical composition of essential oil of Piper bellidifolium, Piper durilignum, Piper acutilimbum and Piper consanguineum from the Brazilian Amazon forest

et al. 2018

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Piper bellidifolium, Piper durilignum, Piper acutilimbum and Piper consanguineum are bushes that occur in the Amazon and are morphologically similar. With the aim of analyzing the chemical profile of the volatile constituents of these species, essential oils from the leaves were obtained through steam distillation and analyzed using gas chromatography-flame ionization detection (GC-FID) and gas chromatograph coupled to a mass spectrometer (GC-MS). The chemical analysis enabled the identification of 95 compounds representing 96.3 ± 0.6% of the P. bellidifolium oil, 95.5 ± 0.71% of the P. durilignum oil, 98.0 ± 1.0% of the P. acutilimbum oil and 96.1 ± 2.1% of the P. consanguineum oil. Although sesquiterpenes were the predominant chemical class in the oils of the four species, qualitative and quantitative differences were found in their chemical composition. The major constituents were (E)-nerolidol (20.3 ± 0.4%) in the P. bellidifolium oil, germacrene D (11.1 ± 0.3%) in the P. durilignum oil, and γ-eudesmol in both the P. consanguineum (18.6 ± 0.5%) and P. acutilimbum (7.5 ± 0.4%) oils. Despite their morphological similarity, a principal component analysis (PCA) of the GC-MS data clearly separated the four species according to the chemical profile of the essential oil extracted from their leaves.

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“…The reagents were prepared according to the standard protocol (Lipoxygenase inhibitor screening assay kit, Item No. 760700 Cayman Chemicals Co) [7][8][9]. Stock solutions of samples were prepared so as to obtain various concentrations (extracts: 1000-62.5 μg/mL; compounds 100−6.25 µM) in the respective wells.…”

Section: Methodsmentioning

confidence: 99%

Chemical constituents and lipoxygenase inhibitory activity of Piper stylosum Miq.

Salleh¹,

Hashim²,

Khamis³

2019

Bull. Chem. Soc. Eth.

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Chemical constituents and lipoxygenase inhibitory activity of the aerial part of Piper stylosum have been studied. Fractionation and purification of the extracts afforded five lignans, identified as yangambin (1), sesamin (2), syringaresinol (3), pinoresinol (4), and medioresinol (5), together with other constituents; 4-allyl resorcinol, β-sitosterol, β-sitostenone, taraxerol, vanilin, and vanilic acid. The structures of these compounds were established by analysis of their spectral data, as compared to that of reported compounds. The lipoxygenase inhibitory activity of the extracts and isolated lignans were also evaluated.

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Antioxidant and Anti-inflammatory Activities of Essential Oil and Extracts of Piper miniatum

Cited by 29 publications

References 19 publications

Detection of Gamma Interferon and Some Pro-Inflammatory Cytokines in SPF Chicks Experimentally Infected with Chicken Anemia Virus

Detection of Gamma Interferon and Some Pro-Inflammatory Cytokines in SPF Chicks Experimentally Infected with Chicken Anemia Virus

First record of the chemical composition of essential oil of Piper bellidifolium, Piper durilignum, Piper acutilimbum and Piper consanguineum from the Brazilian Amazon forest

Chemical constituents and lipoxygenase inhibitory activity of Piper stylosum Miq.

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