Antioxidant and Anti-Inflammatory Activities of Quercetin 7-O-β-D-Glucopyranoside from the Leaves ofBrasenia schreberi

Legault, Jean; Perron, Tommy; Mshvildadze, Vakhtang; Girard-Lalancette, Karl; Perron, Stéphanie; Laprise, Catherine; Sirois, Pascal; Pichette, André

doi:10.1089/jmf.2010.0198

Cited by 54 publications

(40 citation statements)

References 33 publications

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“…In another study, quercetin 7 was found to possess anti-inflammatory activity, inhibiting expression of inducible nitric oxide synthase and release of nitric oxide by lipopolysaccharide-stimulated RAW 264.7 macrophages in a dose-dependent manner. Quercetin 7 also inhibited overexpression of cyclooxygenase-2 and granulocyte macrophage-colony-stimulating factor (Legault et al, 2011).…”

Section: Molecular Parametersmentioning

confidence: 93%

In silico pharmacodynamics, toxicity profile and biological activities of the Saharan medicinal plant Limoniastrum feei

Ouahab

2017

Braz. J. Pharm. Sci.

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In-silico study was performed to find the pharmacodynamics, toxicity profiles and biological activities of three phytochemicals isolated from Limoniastrum feei (Plumbagenaceae). Online pharmacokinetic tools were used to estimate the potential of Quercetin, kaempferol-3-O-β-D-glucopyranoside (astragalin) and quercitin-7-O-β-D-glucopyranoside as specific drugs. Then the prediction of potential targets of these compounds were investigated using PharmMapper. Auto-Dock 4.0 software was used to investigate the different interactions of these compounds with the targets predicted earlier. The permeability of quercetin was found within the range stated by Lipinski ‫׳‬s rule of five. Hematopoietic prostaglandin (PG) D synthase (HPGDS), farnesyl diphosphate synthetase (FPPS) and the deoxycytidine kinase (DCK) were potential targets for quercetin, astragalin and quercetin 7, respectively. Quercetin showed antiallergic and anti-inflammatory activity, while astragalin and quercetin 7 were predicted to have anticancer activities. The activity of Astragalin appeared to be mediated by FPPS inhibition. The inhibition of DCK was predicted as the anticancer mechanisms of quercetin 7. The compounds showed interesting interactions and satisfactory binding energies when docked into their targets. These compounds are proposed to have activities against a variety of human aliments such as allergy, tumors, muscular dystrophy, and diabetic cataracts.

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Section: Molecular Parametersmentioning

confidence: 93%

In silico pharmacodynamics, toxicity profile and biological activities of the Saharan medicinal plant Limoniastrum feei

Ouahab

2017

Braz. J. Pharm. Sci.

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“…1 isolated from Hibiscus cannabinus L. showed signifi cant anti-infl ammatory (21). 3 and 6 were also isolated from the leaves of Brasenia schreberi, and both compounds exhibited anti-inflammatory activities (22). Our results suggested that highly-enriched 4 and 5 may be the best active constituents related to the traditional utilization of this herb.…”

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confidence: 62%

Anti-inflammatory activities of fractions from Geranium nepalense and related polyphenols

Chen

et al. 2012

Drug Discov Ther

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Geranium nepalense Sweet is a common Chinese herbal medicine and has been used as influenza, dysentery, antiphlogistic and analgesic tonic, hemostatic, stomachic, and antidiabetic drugs. The anti-inflammatory effects of G. nepalense on tetradecanoyl phorbol acetate (TPA)-induced mouse ear edema were studied in this work. The results showed that ethyl acetate fraction of the water extract of G. nepalense possessed significant activity at 2.5 g/kg (p < 0.01) with aspirin as a positive control (0.6 g/kg). Six polyphenolic compounds, including three flavonoids, i.e. kaempferol, kaempferol-7-O-β-D-glucopyranoside, and quercetin-7-O-α-rhamnopyranoside, and two tannins, i.e. pyrogallol and gallic acid, and one lignin, i.e. epipinoresinol, were isolated and characterized from ethyl acetate fraction. The isolation of polyphenols provides a clue for beneficial effects of G. nepalense in the demonstrated anti-inflammatory activity.

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“…In fact, the IC 50 values relative to the DPPH• radical-scavenging activities of compounds 1 , 3 , 4 , 5 , 7 , 8 and 10 were 18, 5.2, 0.8, 50.8, 0.2, 1.7 and 9.2 μg/ml, respectively [20–24]. Moreover, Legault et al [25] reported that quercetin-7- O -β-D-glucopyranoside (compound 9 ) exhibit a strong antioxidant potential in the oxygen radical absorbance capacity assay. These results confirmed our previous findings, showing that D. simplex flowers contain relatively high flavonoids level (74.2 ± 3.4 mg QE/g extract) and display an interesting antioxidant potential as shown through various antioxidant mechanisms, including the β-carotene bleaching protection (IC 50 = 12.5 ± 0.02 μg/ml), Fe 3+ reducing (EC 50 = 0.10 ± 0.01 mg/ml), DPPH• radical-scavenging (IC 50 = 0.20 ± 0.02 mg/ml) and Fe 2+ chelating (IC 50 = 0.60 ± 0.02 mg/ml) assays as well as through DNA damage protection [12].…”

Section: Resultsmentioning

confidence: 99%

“…Indeed, the IC 50 values relative to aldose reductase activity inhibition of compounds 7 and 8 were found to be 15.2 and 7.4 μg/ml, respectively [28]. Legault et al [25] also mentioned that quercetin-7- O -β-D-glucopyranoside (compound 9 ) possesses important anti-inflammatory activity by inhibiting NO release, inducible nitric oxide synthase and cyclooxygenase-2 expression, and granulocyte macrophage colony-stimulating factor overproduction. On the other hand, the flavonol diglycoside rhamnetin 3,3’-di- O -β-D-glucopyranoside (compound 1 ), that was previously isolated from Diplotaxis virgata and Diplotaxis erucoides , exhibited an interesting antibacterial activity [23].…”

Section: Resultsmentioning

confidence: 99%

The cruciferous Diplotaxis simplex: Phytochemistry analysis and its protective effect on liver and kidney toxicities, and lipid profile disorders in alloxan-induced diabetic rats

et al. 2017

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BackgroundType 2 diabetes mellitus is a prevalent systemic disease affecting an important proportion of the population worldwide. It has been suggested that excessive reactive oxygen species generation and therefore development of an oxidative stress status is a key factor leading to diabetic complications. Accordingly, it seems that medicinal plants can offer a wide range of new antidiabetic drugs. Diplotaxis simplex (Viv.) Spreng. (Brassicaceae) is an edible plant largely distributed in the Mediterranean region. D. simplex flowers display important in vitro antioxidant potential and inhibitory activity of the α-glucosidase, a key enzyme linked to type 2 diabetes mellitus. In this paper, the antihyperglycemic potential of D. simplex flowers on diabetic rats were investigated.MethodsBioactive substances were determined by liquid chromatography-high resolution electrospray ionization mass spectrometry (LC-HRESIMS) analysis. Animals were divided into four groups of six rats each: a normal control group, a diabetic control group, a diabetic group receiving flowers extract (200 mg/kg body mass) and a diabetic group receiving acarbose (10 mg/kg body mass) as standard drug.ResultsMany glycosides of rhamnetin, isorhamnetin, quercetin and kaempferol compounds were identified in the ethanolic flowers extract. Alloxan induced hyperglycemia, manifested by a significant (p < 0.05) increase in the blood glucose level as well as in serum α-amylase activity. Furthermore, diabetic rats exhibited oxidative stress, as evidenced by a decrease in antioxidant enzymes activities and an increase in lipid peroxidation level of the pancreas, liver and kidneys. Interestingly, the oral administration of D. simplex flowers extract during 30 days restored the glycemia, α-amylase activity, serum lipid profile and antioxidant enzymes. Moreover, the flowers extract exhibited a renal protective role by decreasing the urea and creatinine levels in diabetic rats serum.Conclusions D. simplex flowers contained bioactive compounds that possess important antioxidant and hypoglycemic properties and protected pancreas, liver and kidneys against hyperglycemia damage.

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Antioxidant and Anti-Inflammatory Activities of Quercetin 7-O-β-D-Glucopyranoside from the Leaves ofBrasenia schreberi

Cited by 54 publications

References 33 publications

In silico pharmacodynamics, toxicity profile and biological activities of the Saharan medicinal plant Limoniastrum feei

In silico pharmacodynamics, toxicity profile and biological activities of the Saharan medicinal plant Limoniastrum feei

Anti-inflammatory activities of fractions from Geranium nepalense and related polyphenols

The cruciferous Diplotaxis simplex: Phytochemistry analysis and its protective effect on liver and kidney toxicities, and lipid profile disorders in alloxan-induced diabetic rats

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