Antioxidant and anti-inflammatory activity of extracts from red beet (Beta vulagaris) root

Abstract

This study was designed to examine the in vitro antioxidant and anti-inflammatory effects of red beet (Beta vulagaris) root. Red beet root was extracted using 70% ethanol and then fractionated sequentially with n-hexane, ethyl acetate and butanol. Antioxidative ability was evaluated by bioassays using total polyphenol contents and ABTS (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid diammonium salt) radical scavenging activity. Ethyl acetate fraction of red beet root was best on total polyphenol contents (37.02±0.37 mg GAE/g) and ABTS radical scavenging effects (IC50 42.9±9.5 μg/mL). For the anti-inflammatory activity in RAW264.7 cells, the hexane fraction showed the highest inflammatory effect. Dose response studies were performed to determine the inhibitory effect of hexane fraction of red beet root on pro-inflammatory mediators in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The hexane fraction of red beet root inhibited the NO and PGE2 production and the protein level of iNOS and COX-2, and protein expression of pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β), in a dose-dependent manner. These results suggest that red beet root has considerable potential as a functional food ingredient with antioxidative and anti- inflammatory effects.

Anti-inflammatory Effect of Wild Indigo (Baptisia tinctoria) Root on Raw 264.7 Cells with Stimulated Lipopolysaccharide

“…2A. In a previous study, it was reported that the NO production inhibition effect through iNOS expression inhibition was greater than that of the red beetroot extract by COX-2 inhibition of PGE2 synthesis could be confirmed (Yi et al, 2017).…”

Evaluation of the Antifungal Effect of Rhus verniciflua Stokes Extract for Oral Application Potential

“…Interest in adverse substances with environmentally friendly functions is increasing [ 45 ]. Recently, studies on disease treatment and prevention using natural products and the development of health-functional materials have been actively conducted [ 46 ]. Therefore, the viability of natural antioxidants is evaluated by measuring antioxidant compounds and their activity.…”

Effects of Electro-conductivity on Growth of Beet and Turnip in the Reclaimed Land Soil

“…비트(Beta vularis L.)는 유럽 남부 및 지중해 연안이 원 산지로 쌍떡잎식물강 명아주과(Chenopodiceae)의 두해살이 풀이다. 비트는 칼로리가 낮고 각종 미네랄과 비타민이 풍부 하여 다양하게 건강상의 유익함을 줄 수 있는 식물이다 (Yi et al, 2017). 작물의 내염성(saline tolerant)은 식물이 생육하는 배지에서 과도한 염의 영향을 견딜 수 있는 식물의 능력이다.…”